ICD-10-CM Code C78.1

Secondary malignant neoplasm of mediastinum

Version 2021 Billable Code Neoplasm Malignant Secondary

Valid for Submission

C78.1 is a billable code used to specify a medical diagnosis of secondary malignant neoplasm of mediastinum. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code C78.1 might also be used to specify conditions or terms like anterior mediastinum mass, hypopharyngeal tnm finding, malignant neoplasm of anterior mediastinum, malignant neoplasm of posterior mediastinum, mediastinum involved by direct extension of malignant neoplasm, metastasis to mediastinum of unknown primary, etc

The following anatomical sites found in the Table of Neoplasms apply to this code given the correct histological behavior: Neoplasm, neoplastic mediastinum, mediastinal or Neoplasm, neoplastic mediastinum, mediastinal anterior or Neoplasm, neoplastic mediastinum, mediastinal posterior or Neoplasm, neoplastic substernal .

Short Description:Secondary malignant neoplasm of mediastinum
Long Description:Secondary malignant neoplasm of mediastinum


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Anterior mediastinum mass
  • Hypopharyngeal TNM finding
  • Malignant neoplasm of anterior mediastinum
  • Malignant neoplasm of posterior mediastinum
  • Mediastinum involved by direct extension of malignant neoplasm
  • Metastasis to mediastinum of unknown primary
  • Neoplasm of anterior mediastinum
  • Neoplasm of posterior mediastinum
  • pT4b: Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures
  • pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures
  • pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures
  • Secondary malignant neoplasm of anterior mediastinum
  • Secondary malignant neoplasm of mediastinum
  • Secondary malignant neoplasm of posterior mediastinum
  • Subglottis TNM finding
  • Supraglottis TNM finding
  • T4: Lung tumor of any size that invades any of the following: mediastinum; heart; great vessels; trachea; esophagus; vertebral body; carina
  • Tumor invades mediastinum

Diagnostic Related Groups

The ICD-10 code C78.1 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert C78.1 to ICD-9

  • 197.1 - Sec mal neo mediastinum

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of ill-defined, other secondary and unspecified sites (C76-C80)
      • Secondary malignant neoplasm of resp and digestive organs (C78)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Table of Neoplasms

The code C78.1 is included in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
CaInSitu Benign Uncertain
»Neoplasm, neoplastic
  »mediastinum, mediastinal
»Neoplasm, neoplastic
  »mediastinum, mediastinal
»Neoplasm, neoplastic
  »mediastinum, mediastinal
»Neoplasm, neoplastic

Information for Patients

Lung Cancer

Also called: Bronchogenic carcinoma

Lung cancer is one of the most common cancers in the world. It is a leading cause of cancer death in men and women in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. High levels of pollution, radiation and asbestos exposure may also increase risk.

Common symptoms of lung cancer include

  • A cough that doesn't go away and gets worse over time
  • Constant chest pain
  • Coughing up blood
  • Shortness of breath, wheezing, or hoarseness
  • Repeated problems with pneumonia or bronchitis
  • Swelling of the neck and face
  • Loss of appetite or weight loss
  • Fatigue

Doctors diagnose lung cancer using a physical exam, imaging, and lab tests. Treatment depends on the type, stage, and how advanced it is. Treatments include surgery, chemotherapy, radiation therapy, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

  • After chemotherapy - discharge (Medical Encyclopedia)
  • Coughing up blood (Medical Encyclopedia)
  • Lung cancer (Medical Encyclopedia)
  • Lung cancer - non-small cell (Medical Encyclopedia)
  • Lung cancer - small cell (Medical Encyclopedia)
  • Lung PET scan (Medical Encyclopedia)
  • Lung surgery (Medical Encyclopedia)
  • Metastatic cancer to the lung (Medical Encyclopedia)
  • Solitary pulmonary nodule (Medical Encyclopedia)

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