2026 ICD-10-CM Diagnosis Code C49.5Malignant neoplasm of connective and soft tissue of pelvis
ICD-10-CM Codes›C00–D49›C45-C49›C49
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 21
- Chronic Condition
C49.5 is a billable ICD-10-CM diagnosis code for malignant neoplasm of connective and soft tissue of pelvis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 542 through 544. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 2 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sarcoma.
For Medicare Advantage risk adjustment, C49.5 maps to CMS-HCC Category 21 (Lymphoma and Other Cancers) under the V28 model, adding a risk factor of about 0.671 for a community, non-dual, aged beneficiary in payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C49.5 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2026.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Malignant neoplasm of soft tissue of buttock
- Malignant neoplasm of soft tissue of pelvis
- Neoplasm of blood vessel of buttock
- Neoplasm of blood vessel of inguinal region
- Neoplasm of blood vessel of pelvis
- Neoplasm of blood vessel of perineum
- Neoplasm of coccygeal body
- Neoplasm of muscle of buttock
- Neoplasm of muscle of hip
- Neoplasm of muscle of inguinal region
- Neoplasm of muscle of pelvis
- Neoplasm of muscle of perineum
- Neoplasm of soft tissues of inguinal region
- Primary angiosarcoma of inguinal region
- Primary angiosarcoma of pelvis
- Primary angiosarcoma of trunk
- Primary leiomyosarcoma of buttock
- Primary leiomyosarcoma of inguinal region
- Primary leiomyosarcoma of pelvis
- Primary leiomyosarcoma of perineum
- Primary liposarcoma of soft tissue of buttock
- Primary liposarcoma of soft tissue of inguinal region
- Primary liposarcoma of soft tissue of limb
- Primary liposarcoma of soft tissue of pelvis
- Primary liposarcoma of soft tissue of perineum
- Primary liposarcoma of soft tissue of trunk
- Primary malignant fibrous histiocytoma of buttock
- Primary malignant fibrous histiocytoma of soft tissue of lower limb
- Primary malignant neoplasm of blood vessel of buttock
- Primary malignant neoplasm of blood vessel of inguinal region
- Primary malignant neoplasm of blood vessel of lower limb
- Primary malignant neoplasm of blood vessel of pelvis
- Primary malignant neoplasm of blood vessel of perineum
- Primary malignant neoplasm of blood vessel of trunk
- Primary malignant neoplasm of coccygeal body
- Primary malignant neoplasm of inguinal region
- Primary malignant neoplasm of muscle of buttock
- Primary malignant neoplasm of muscle of hip
- Primary malignant neoplasm of muscle of inguinal region
- Primary malignant neoplasm of muscle of lower limb
- Primary malignant neoplasm of muscle of pelvis
- Primary malignant neoplasm of muscle of perineum
- Primary malignant neoplasm of muscle of trunk
- Primary malignant neoplasm of paraganglion
- Primary malignant neoplasm of skin of perineum
- Primary malignant neoplasm of soft tissues of buttock
- Primary malignant neoplasm of soft tissues of inguinal region
- Primary malignant neoplasm of soft tissues of pelvis
- Primary malignant neoplasm of soft tissues of perineum
- Primary rhabdomyosarcoma of buttock
- Primary rhabdomyosarcoma of inguinal region
- Primary rhabdomyosarcoma of pelvis
- Primary rhabdomyosarcoma of perineum
- Primary sarcoma of buttock
- Primary sarcoma of inguinal region
- Primary sarcoma of perineum
- Sarcoma of pelvis
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Malignant neoplasm of buttock
- Malignant neoplasm of groin
- Malignant neoplasm of perineum
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| coccygeal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| coccygeal › body or glomus | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › buttock | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › extrarectal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › gluteal region | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › groin | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › iliopsoas muscle | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › inguinal (canal) (region) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › ischiorectal fossa | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › nates | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › pararectal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › para-urethral | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › paravaginal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › pelvis (floor) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › perineum | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › perirectal (tissue) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › periurethral (tissue) | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › presacral | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › rectovaginal septum or wall | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › rectovesical | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › sacrococcygeal region | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| connective tissue NEC › vesicorectal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| glomus | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
| glomus › coccygeal | C49.5 | C79.89 | – | D21.5 | D48.1 | D49.2 |
Patient EducationClinical
Cancer
Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should.
The full article covers:
- What is cancer?
- What are the types of cancer?
- How does cancer develop?
- What are the symptoms of cancer?
- How is cancer diagnosed?
- What are the treatments for cancer?
- Can cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C49.5 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C49.5Overview
What is the ICD-10 code for malignant neoplasm of connective and soft tissue of pelvis?
The ICD-10-CM code for malignant neoplasm of connective and soft tissue of pelvis is C49.5 (sometimes written as C495). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is C49.5 (Malignant neoplasm of other connective and soft tissue) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of connective and soft tissue of pelvis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does C49.5 group to?
When malignant neoplasm of connective and soft tissue of pelvis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 542, 543, 544, with relative weights from 0.7546 to 1.7665 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C49.5 a CC or MCC?
CMS lists C49.5 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 2 closely related codes in its exclusion list.
What is the ICD-9 equivalent of C49.5?
Under the General Equivalence Mappings, malignant neoplasm of connective and soft tissue of pelvis converts to ICD-9-CM 171.6 (mal neo soft tis pelvis). The mapping is approximate, so confirm the match fits the documentation.
What HCC is C49.5?
C49.5 (malignant neoplasm of connective and soft tissue of pelvis) maps to CMS-HCC Category 21 (Lymphoma and Other Cancers), commonly written as HCC 21, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2026. It mapped to HCC 10 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 22.
Does C49.5 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C49.5 adds a risk adjustment factor of about 0.671 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.493 to 0.739 depending on the payment segment). A more severe related category (HCC 17, HCC 18, HCC 19, and HCC 20) supersedes it when both are reported. See the full factor table on the HCC 21 category page.
