2026 ICD-10-CM Diagnosis Code C49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip

ICD-10-CM Codes›C00–D49›C45-C49›C49

ICD-10-CM C49.22
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C49.22 is a billable ICD-10-CM diagnosis code for malignant neoplasm of connective and soft tissue of left lower limb, including hip. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 542 through 544. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sarcoma.

Code Identity

ICD-10-CM Code
C49.22
Billable Status
Yes — Valid for Submission
Code Describes
Malignant neoplasm of connective and soft tissue of left lower limb, including hip
Short Description
Malig neoplm of conn and soft tiss of left low limb, inc hip
Parent Code
C49.2
Malignant neoplasm of connective and soft tissue of lower limb, including hip

Code Classification

ChapterC00–D49Neoplasms
SectionC45-C49Malignant neoplasms of mesothelial and soft tissue
CategoryC49Malignant neoplasm of other connective and soft tissue
This CodeC49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Mass of muscle of left lower limb
  • Primary angiosarcoma of left hip region
  • Primary angiosarcoma of left lower limb
  • Primary angiosarcoma of trunk
  • Primary leiomyosarcoma of left hip region
  • Primary leiomyosarcoma of left lower limb
  • Primary liposarcoma of soft tissue of left hip
  • Primary liposarcoma of soft tissue of left lower limb
  • Primary liposarcoma of soft tissue of limb
  • Primary malignant fibrous histiocytoma of soft tissue of hip
  • Primary malignant fibrous histiocytoma of soft tissue of left hip
  • Primary malignant fibrous histiocytoma of soft tissue of left lower limb
  • Primary malignant fibrous histiocytoma of soft tissue of lower limb
  • Primary malignant neoplasm of muscle of left lower limb
  • Primary malignant neoplasm of muscle of lower limb
  • Primary malignant neoplasm of soft tissue of left hip
  • Primary malignant neoplasm of soft tissue of left lower limb
  • Primary rhabdomyosarcoma of hip
  • Primary rhabdomyosarcoma of left hip
  • Primary rhabdomyosarcoma of left lower limb
  • Primary sarcoma of left lower limb
  • Primary sarcoma of soft tissues of left hip

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO024
Sarcoma
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
aponeurosis › plantarC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › ankleC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › calfC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › extremity › lowerC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › footC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › heelC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › hipC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › kneeC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › legC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › limb NEC › lowerC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › popliteal fossa or spaceC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › thighC49.2C79.89–D21.2D48.1D49.2
connective tissue NEC › toeC49.2C79.89–D21.2D48.1D49.2
fascia [See Also: Neoplasm, connective tissue] › plantarC49.2C79.89–D21.2D48.1D49.2

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Convert C49.22 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
171.3 Mal neo soft tissue leg
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C49.22Overview

Is C49.22 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of connective and soft tissue of left lower limb, including hip on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C49.22 group to?

When malignant neoplasm of connective and soft tissue of left lower limb, including hip is the principal diagnosis on an inpatient stay, it groups to MS-DRG 542, 543, 544, with relative weights from 0.7546 to 1.7665 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C49.22?

Under the General Equivalence Mappings, malignant neoplasm of connective and soft tissue of left lower limb, including hip converts to ICD-9-CM 171.3 (mal neo soft tissue leg). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.