2026 ICD-10-CM Diagnosis Code C49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder

ICD-10-CM Codes›C00–D49›C45-C49›C49

ICD-10-CM C49.10
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C49.10 is a billable ICD-10-CM diagnosis code for malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 542 through 544. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sarcoma.

Code Identity

ICD-10-CM Code
C49.10
Billable Status
Yes — Valid for Submission
Code Describes
Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
Short Description
Malig neoplm of conn & soft tiss of unsp upr lmb, inc shldr
Parent Code
C49.1
Malignant neoplasm of connective and soft tissue of upper limb, including shoulder

Code Classification

ChapterC00–D49Neoplasms
SectionC45-C49Malignant neoplasms of mesothelial and soft tissue
CategoryC49Malignant neoplasm of other connective and soft tissue
This CodeC49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Angiosarcoma of skin
  • Lymphangiosarcoma
  • Malignant neoplasm of soft tissue of axilla
  • Malignant neoplasm of soft tissue of finger
  • Malignant neoplasm of soft tissue of hand
  • Malignant neoplasm of soft tissue of shoulder
  • Malignant neoplasm of soft tissue of thumb
  • Malignant neoplasm of soft tissue of upper limb
  • Malignant neoplasm of soft tissue of wrist
  • Neoplasm of blood vessel of finger
  • Neoplasm of blood vessel of forearm
  • Neoplasm of blood vessel of hand
  • Neoplasm of blood vessel of shoulder
  • Neoplasm of blood vessel of upper arm
  • Neoplasm of muscle of shoulder
  • Primary angiosarcoma of shoulder region
  • Primary malignant fibrous histiocytoma of soft tissue of shoulder
  • Primary malignant fibrous histiocytoma of soft tissue of upper limb
  • Primary malignant neoplasm of blood vessel of finger
  • Primary malignant neoplasm of blood vessel of forearm
  • Primary malignant neoplasm of blood vessel of hand
  • Primary malignant neoplasm of blood vessel of shoulder
  • Primary malignant neoplasm of blood vessel of upper arm
  • Primary malignant neoplasm of blood vessel of upper limb
  • Primary malignant neoplasm of forearm
  • Primary malignant neoplasm of muscle of shoulder
  • Primary malignant neoplasm of muscle of upper limb
  • Primary malignant neoplasm of soft tissues of shoulder
  • Primary malignant neoplasm of soft tissues of upper limb
  • Primary malignant neoplasm of upper arm
  • Primary rhabdomyosarcoma of shoulder region
  • Stewart-Treves syndrome

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO024
Sarcoma
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Lymphangiosarcoma

    a malignant tumor originating from the endothelial cells of lymphatic vessels. most lymphangiosarcomas arise in an arm secondary to radical mastectomy but they sometimes complicate idiopathic lymphedema. the lymphedema has usually been present for 6 to 10 years before malignant changes develop. (from dorland, 27th ed; holland et al., cancer medicine, 3d ed, p1866)

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
aponeurosis › palmarC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › antecubital fossa or spaceC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › armC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › elbowC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › extremity › upperC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › fingerC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › forearmC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › handC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › limb NEC › upperC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › shoulderC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › thumbC49.1C79.89–D21.1D48.1D49.2
connective tissue NEC › wristC49.1C79.89–D21.1D48.1D49.2
fascia [See Also: Neoplasm, connective tissue]C49.1C79.89–D21.1D48.1D49.2
fascia [See Also: Neoplasm, connective tissue] › palmarC49.1C79.89–D21.1D48.1D49.2

Patient EducationClinical

Cancer

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Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert C49.10 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
171.2 Mal neo soft tissue arm
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C49.10Overview

Is C49.10 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C49.10 group to?

When malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder is the principal diagnosis on an inpatient stay, it groups to MS-DRG 542, 543, 544, with relative weights from 0.7546 to 1.7665 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C49.10?

Under the General Equivalence Mappings, malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder converts to ICD-9-CM 171.2 (mal neo soft tissue arm). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.