2026 ICD-10-CM Diagnosis Code Z15.81Genetic susceptibility to multiple endocrine neoplasia [MEN]

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15.81
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z15.81 is a billable ICD-10-CM diagnosis code for genetic susceptibility to multiple endocrine neoplasia [MEN]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as genetic predisposition to multiple endocrine adenomatosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genetic susceptibility to disease.

Code Identity

ICD-10-CM Code
Z15.81
Billable Status
Yes — Valid for Submission
Code Describes
Genetic susceptibility to multiple endocrine neoplasia [MEN]
Short Description
Genetic susceptibility to multiple endocrine neoplasia [MEN]
Same as the full description in the CMS dataset.
Parent Code
Z15.8
Genetic susceptibility to other disease

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15.81Genetic susceptibility to multiple endocrine neoplasia [MEN]

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z15.81.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z15.81 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Genetic predisposition to multiple endocrine adenomatosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • multiple endocrine neoplasia MEN syndromes E31.2

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Genetic
      • susceptibility to disease NEC
        • multiple endocrine neoplasia
    • Susceptibility to disease, genetic
      • multiple endocrine neoplasia

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC029
Genetic susceptibility to disease
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Multiple endocrine neoplasia

Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands called the endocrine system. Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z15.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V84.81 Genetc sus mult endo neo
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z15.81Overview

Is Z15.81 (Genetic susceptibility to other disease) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report genetic susceptibility to multiple endocrine neoplasia [MEN] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z15.81 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because genetic susceptibility to multiple endocrine neoplasia [MEN] describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z15.81 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for genetic susceptibility to multiple endocrine neoplasia [MEN] on inpatient claims.

What is the ICD-9 equivalent of Z15.81?

Under the General Equivalence Mappings, genetic susceptibility to multiple endocrine neoplasia [MEN] converts to ICD-9-CM V84.81 (genetc sus mult endo neo). The mapping is a direct match.