2026 ICD-10-CM Diagnosis Code T50.5X5SAdverse effect of appetite depressants, sequela
T50.5X5S is a billable ICD-10-CM diagnosis code for adverse effect of appetite depressants, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as amphetamine group adverse reaction. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T50.5X5S.
Present on Admission (POA)Billing
T50.5X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Amphetamine group adverse reaction
- Centrally acting appetite suppressant adverse reaction
- Dexfenfluramine adverse reaction
- Diethylpropion adverse reaction
- Fenfluramine adverse reaction
- Mazindol adverse reaction
- Phentermine adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Aminorex
an amphetamine-like anorectic agent. it may cause pulmonary hypertension.Benzphetamine
a sympathomimetic agent with properties similar to dextroamphetamine. it is used in the treatment of obesity. (from martindale, the extra pharmacopoeia, 30th ed, p1222)Chlorphentermine
a sympathomimetic agent that was formerly used as an anorectic. it has properties similar to those of dextroamphetamine. it has been implicated in lipid storage disorders and pulmonary hypertension. (from martindale, the extra pharmacopoeia, 30th ed, p1223)Dexfenfluramine
the s-isomer of fenfluramine. it is a serotonin agonist and is used as an anorectic. unlike fenfluramine, it does not possess any catecholamine agonist activity.Diethylpropion
a appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. it is also considered to be among the safest for patients with hypertension. (from ama drug evaluations annual, 1994, p2290)Fenfluramine
a centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.Mazindol
tricyclic anorexigenic agent unrelated to and less toxic than amphetamine, but with some similar side effects. it inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.Phenmetrazine
a sympathomimetic drug used primarily as an appetite depressant. its actions and mechanisms are similar to dextroamphetamine.Phentermine
a central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. it has been used most frequently in the treatment of obesity.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T50.5X5S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T50.5X5SOverview
Is T50.5X5S (Adverse effect of appetite depressants) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of appetite depressants, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T50.5X5S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of appetite depressants itself has resolved, not the original event.
What MS-DRG does T50.5X5S group to?
On inpatient claims, adverse effect of appetite depressants, sequela maps to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T50.5X5S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of appetite depressants, sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T50.5X5S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of appetite depressants, sequela on inpatient claims.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
