2026 ICD-10-CM Diagnosis Code T48.6X1SPoisoning by antiasthmatics, accidental (unintentional), sequela

ICD-10-CM CodesS00–T88T36-T50T48

ICD-10-CM T48.6X1S
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

T48.6X1S is a billable ICD-10-CM diagnosis code for poisoning by antiasthmatics, accidental (unintentional), sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.

Code Identity

ICD-10-CM Code
T48.6X1S
Billable Status
Yes — Valid for Submission
Code Describes
Poisoning by antiasthmatics, accidental (unintentional), sequela
Short Description
Poisoning by antiasthmatics, accidental, sequela
Parent Code
Poisoning by antiasthmatics, accidental (unintentional)

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT48Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system
This CodeT48.6X1SPoisoning by antiasthmatics, accidental (unintentional), sequela

Present on Admission (POA)Billing

T48.6X1S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Accidental aminophylline overdose
  • Accidental aminophylline poisoning
  • Accidental bronchodilator preparations overdose
  • Accidental overdose of isoprenaline
  • Accidental phosphodiesterase inhibitor overdose
  • Accidental phosphodiesterase inhibitor poisoning
  • Accidental poisoning by adrenergics
  • Accidental salbutamol overdose
  • Accidental salbutamol poisoning
  • Accidental theophylline overdose
  • Accidental theophylline poisoning
  • Aminophylline overdose
  • Beta-adrenoceptor agonist overdose
  • Bronchodilator preparations overdose
  • Isoprenaline overdose
  • Poisoning by aminophylline
  • Poisoning by antiasthmatic
  • Poisoning by theobromine
  • Poisoning by theophylline
  • Salbutamol overdose
  • Salbutamol poisoning
  • Theophylline overdose
  • Xanthine and/or xanthine derivative overdose

Coding GuidelinesGuidance

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (T48). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ075
Poisoning/toxic effect/adverse effects/underdosing, sequela
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Albuterol

    a short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat asthma. albuterol is prepared as a racemic mixture of r(-) and s(+) stereoisomers. the stereospecific preparation of r(-) isomer of albuterol is referred to as levalbuterol.
  • Albuterol, Ipratropium Drug Combination

    a combined pharmaceutical preparation of ipratropium bromide and albuterol sulfate that is used to treat the symptoms of asthma and chronic obstructive pulmonary disease.
  • Aminophylline

    a drug combination that contains theophylline and ethylenediamine. it is more soluble in water than theophylline but has similar pharmacologic actions. it's most common use is in bronchial asthma, but it has been investigated for several other applications.
  • Choline

    a basic constituent of lecithin that is found in many plants and animal organs. it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
  • Choline Deficiency

    a condition produced by a deficiency of choline in animals. choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. combined deficiency of choline (included in the b vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (from saunders dictionary & encyclopedia of laboratory medicine and technology, 1984)
  • Choline Dehydrogenase

    an enzyme bound to the inner mitochondrial membrane that catalyzes the oxidation of choline to betaine.
  • Choline Kinase

    an enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of atp. ethanolamine and its methyl and ethyl derivatives can also act as acceptors. ec 2.7.1.32.
  • Choline O-Acetyltransferase

    an enzyme that catalyzes the formation of acetylcholine from acetyl-coa and choline. ec 2.3.1.6.
  • Choline-Phosphate Cytidylyltransferase

    an enzyme that catalyzes the transfer of cytidylate (cmp) to choline phosphate to form cdpcholine. it is the rate-limiting enzyme in the choline pathway for the biosynthesis of phosphatidylcholine. its activity is increased by glucocorticoids. ec 2.7.7.15.
  • Cholinergic Agents

    any drug used for its actions on cholinergic systems. included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. the term cholinergic agents is sometimes still used in the narrower sense of muscarinic agonists, although most modern texts discourage that usage.
  • Cholinergic Agonists

    drugs that bind to and activate cholinergic receptors.
  • Cholinergic Antagonists

    drugs that bind to but do not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
  • Cholinergic Fibers

    nerve fibers liberating acetylcholine at the synapse after an impulse.
  • Cholinergic Neurons

    neurons whose primary neurotransmitter is acetylcholine.
  • Cholinesterase Inhibitors

    drugs that inhibit cholinesterases. the neurotransmitter acetylcholine is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. when cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
  • Cholinesterase Reactivators

    drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. they are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.
  • Cholinesterases

    drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. they are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.
  • Cytidine Diphosphate Choline

    donor of choline in biosynthesis of choline-containing phosphoglycerides.
  • Diacylglycerol Cholinephosphotransferase

    an enzyme that catalyzes the synthesis of phosphatidylcholines from cdpcholine and 1,2-diacylglycerols. ec 2.7.8.2.
  • Glycerylphosphorylcholine

    a component of phosphatidylcholines or lecithins, in which the two hydroxy groups of glycerol are esterified with fatty acids. (from stedman, 26th ed)
  • Leukemia Inhibitory Factor

    an interleukin-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. leukemia inhibitory factor binds to and acts through the lif receptor.
  • Muscarinic Agonists

    drugs that bind to and activate muscarinic cholinergic receptors (receptors, muscarinic). muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the gi tract, urinary bladder and the eye. they may also be used to reduce heart rate.
  • Muscarinic Antagonists

    drugs that bind to but do not activate muscarinic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, gi system, and salivary glands, gi motility, urinary bladder tone, and the central nervous system.
  • Neuroimmunomodulation

    the biochemical and electrophysiological interactions between the nervous system and immune system.
  • Nicotinic Agonists

    drugs that bind to and activate nicotinic cholinergic receptors (receptors, nicotinic). nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.
  • Non-Neuronal Cholinergic System

    the system of acetylcholine-synthesizing enzymes, transporters, receptors and degrading enzymes that characterize non-neuronal cholinergic cells such as airway and skin epithelial cells.
  • Phosphatidylcholines

    derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety.
  • Phosphorylcholine

    calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
  • Receptors, Cholinergic

    cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
  • Solute Carrier Family 44, Member 2 Protein

    a mitochondrion and plasma membrane protein that enables choline transmembrane transporter activity.
  • Clenbuterol

    a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. it is used as a bronchodilator in asthma.
  • Fenoterol

    a synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
  • Hexoprenaline

    stimulant of adrenergic beta 2 receptors. it is used as a bronchodilator, antiasthmatic agent, and tocolytic agent.
  • Isoproterenol

    isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. it is used mainly as bronchodilator and heart stimulant.
  • Levalbuterol

    the r-isomer of albuterol.
  • Nedocromil

    a pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils; neutrophils; macrophages; mast cells; monocytes; and platelets.
  • Terbutaline

    a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
  • Theophylline

    a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. theophylline inhibits the 3',5'-cyclic nucleotide phosphodiesterase that degrades cyclic amp thus potentiates the actions of agents that act through adenylyl cyclases and cyclic amp.
  • Tretoquinol

    an adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
Acefylline piperazineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AcepifyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AlbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AmbuphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AminophyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AmlexanoxT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Antiasthmatic drug NECT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BambuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BamifyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BitolterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Bronchodilator NECT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BroxaterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BufrolinT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BufyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ButetamateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
CarbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
CholineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline::chlorideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline::dihydrogen citrateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline::salicylateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline::theophyllinateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ClenbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ClorprenalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Cromoglicic acidT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
CromolynT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
DoxantrazoleT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EnprofyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EtafedrineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EtamiphyllinT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Ethylenediamine theophyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EthylnorepinephrineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
FenoterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
FlunisolideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Flutropium bromideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Folium stramoniaeT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
GlyphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
HexoprenalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Ipratropium (bromide)T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IsoetarineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IsoprenalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IsoproterenolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
LevalbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
LevoproxyphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
MethoxyphenamineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
NedocromilT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Oxitropium bromideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
OxtriphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Pemirolast (potassium)T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
PirbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ProtokylolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ProxyphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ReproterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
RimiterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
SalbutamolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
SalmeterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
StramoniumT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Stramonium::natural stateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TerbutalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theobromine (calcium salicylate)T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theobromine (calcium salicylate)::sodium salicylateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TheophyllamineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TheophyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theophylline::aminobenzoic acidT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theophylline::ethylenediamineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theophylline::piperazine p-amino-benzoateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TretoquinolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TulobuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6

Patient EducationClinical

Medication Errors

Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T48.6X1S to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
909.0 Late eff drug poisoning
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E929.2 Late eff acc poisoning
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About T48.6X1SOverview

Is T48.6X1S (Poisoning by antiasthmatics, accidental (unintentional)) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by antiasthmatics, accidental (unintentional), sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What does the 7th character S in T48.6X1S mean?

The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by antiasthmatics, accidental (unintentional) itself has resolved, not the original event.

What MS-DRG does T48.6X1S group to?

When poisoning by antiasthmatics, accidental (unintentional), sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.

Is T48.6X1S exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by antiasthmatics, accidental (unintentional), sequela on inpatient claims.

What is the ICD-9 equivalent of T48.6X1S?

Under the General Equivalence Mappings, poisoning by antiasthmatics, accidental (unintentional), sequela converts to ICD-9-CM 909.0 (late eff drug poisoning) and E929.2 (late eff acc poisoning). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.