2024 ICD-10-CM Diagnosis Code T48.6X2S

Poisoning by antiasthmatics, intentional self-harm, sequela

ICD-10-CM Code:
T48.6X2S
ICD-10 Code for:
Poisoning by antiasthmatics, intentional self-harm, sequela
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system
        (T48)

T48.6X2S is a billable diagnosis code used to specify a medical diagnosis of poisoning by antiasthmatics, intentional self-harm, sequela. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

T48.6X2S is a sequela code, includes a 7th character and should be used for complications that arise as a direct result of a condition like poisoning by antiasthmatics intentional self-harm. According to ICD-10-CM Guidelines a "sequela" code should be used for chronic or residual conditions that are complications of an initial acute disease, illness or injury. The most common sequela is pain. Usually, two diagnosis codes are needed when reporting sequela. The first code describes the nature of the sequela while the second code describes the sequela or late effect.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Aminophylline overdose
  • Beta-adrenoceptor agonist overdose
  • Beta-adrenoceptor agonist overdose
  • Intentional aminophylline overdose
  • Intentional aminophylline poisoning
  • Intentional bronchodilator preparations overdose
  • Intentional overdose of isoprenaline
  • Intentional phosphodiesterase inhibitor overdose
  • Intentional phosphodiesterase inhibitor poisoning
  • Intentional phosphodiesterase inhibitor poisoning
  • Intentional salbutamol overdose
  • Intentional salbutamol poisoning
  • Intentional theophylline overdose
  • Intentional theophylline poisoning
  • Isoprenaline overdose
  • Poisoning by aminophylline
  • Poisoning by aminophylline
  • Poisoning by theophylline
  • Poisoning by theophylline
  • Salbutamol overdose
  • Salbutamol poisoning
  • Salbutamol poisoning
  • Theophylline overdose
  • Xanthine and/or xanthine derivative overdose
  • Xanthine and/or xanthine derivative overdose

Clinical Classification

Clinical CategoryCCSR Category CodeInpatient Default CCSROutpatient Default CCSR
Mental and substance use disorders; sequelaMBD034Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.
Poisoning/toxic effect/adverse effects/underdosing, sequelaINJ075N - Not default inpatient assignment for principal diagnosis or first-listed diagnosis.N - Not default outpatient assignment for principal diagnosis or first-listed diagnosis.

Clinical Information

  • Albuterol

    a short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat asthma. albuterol is prepared as a racemic mixture of r(-) and s(+) stereoisomers. the stereospecific preparation of r(-) isomer of albuterol is referred to as levalbuterol.
  • Albuterol, Ipratropium Drug Combination

    a combined pharmaceutical preparation of ipratropium bromide and albuterol sulfate that is used to treat the symptoms of asthma and chronic obstructive pulmonary disease.
  • Aminophylline

    a drug combination that contains theophylline and ethylenediamine. it is more soluble in water than theophylline but has similar pharmacologic actions. it's most common use is in bronchial asthma, but it has been investigated for several other applications.
  • Choline

    a basic constituent of lecithin that is found in many plants and animal organs. it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
  • Choline Deficiency

    a condition produced by a deficiency of choline in animals. choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. combined deficiency of choline (included in the b vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (from saunders dictionary & encyclopedia of laboratory medicine and technology, 1984)
  • Choline Dehydrogenase

    an enzyme bound to the inner mitochondrial membrane that catalyzes the oxidation of choline to betaine.
  • Choline Kinase

    an enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of atp. ethanolamine and its methyl and ethyl derivatives can also act as acceptors. ec 2.7.1.32.
  • Choline O-Acetyltransferase

    an enzyme that catalyzes the formation of acetylcholine from acetyl-coa and choline. ec 2.3.1.6.
  • Choline-Phosphate Cytidylyltransferase

    an enzyme that catalyzes the transfer of cytidylate (cmp) to choline phosphate to form cdpcholine. it is the rate-limiting enzyme in the choline pathway for the biosynthesis of phosphatidylcholine. its activity is increased by glucocorticoids. ec 2.7.7.15.
  • Cholinergic Agents

    any drug used for its actions on cholinergic systems. included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. the term cholinergic agents is sometimes still used in the narrower sense of muscarinic agonists, although most modern texts discourage that usage.
  • Cholinergic Agonists

    drugs that bind to and activate cholinergic receptors.
  • Cholinergic Antagonists

    drugs that bind to but do not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
  • Cholinergic Fibers

    nerve fibers liberating acetylcholine at the synapse after an impulse.
  • Cholinergic Neurons

    neurons whose primary neurotransmitter is acetylcholine.
  • Cholinesterase Inhibitors

    drugs that inhibit cholinesterases. the neurotransmitter acetylcholine is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. when cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
  • Cholinesterase Reactivators

    drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. they are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.
  • Cholinesterases

  • Cytidine Diphosphate Choline

    donor of choline in biosynthesis of choline-containing phosphoglycerides.
  • Diacylglycerol Cholinephosphotransferase

    an enzyme that catalyzes the synthesis of phosphatidylcholines from cdpcholine and 1,2-diacylglycerols. ec 2.7.8.2.
  • Glycerylphosphorylcholine

    a component of phosphatidylcholines or lecithins, in which the two hydroxy groups of glycerol are esterified with fatty acids. (from stedman, 26th ed)
  • Leukemia Inhibitory Factor

    an interleukin-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. leukemia inhibitory factor binds to and acts through the lif receptor.
  • Muscarinic Agonists

    drugs that bind to and activate muscarinic cholinergic receptors (receptors, muscarinic). muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the gi tract, urinary bladder and the eye. they may also be used to reduce heart rate.
  • Muscarinic Antagonists

    drugs that bind to but do not activate muscarinic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, gi system, and salivary glands, gi motility, urinary bladder tone, and the central nervous system.
  • Neuroimmunomodulation

    the biochemical and electrophysiological interactions between the nervous system and immune system.
  • Nicotinic Agonists

    drugs that bind to and activate nicotinic cholinergic receptors (receptors, nicotinic). nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.
  • Non-Neuronal Cholinergic System

    the system of acetylcholine-synthesizing enzymes, transporters, receptors and degrading enzymes that characterize non-neuronal cholinergic cells such as airway and skin epithelial cells.
  • Phosphatidylcholines

    derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety.
  • Phosphorylcholine

    calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
  • Receptors, Cholinergic

    cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
  • Clenbuterol

    a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. it is used as a bronchodilator in asthma.
  • Fenoterol

    a synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
  • Hexoprenaline

    stimulant of adrenergic beta 2 receptors. it is used as a bronchodilator, antiasthmatic agent, and tocolytic agent.
  • Isoproterenol

    isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. it is used mainly as bronchodilator and heart stimulant.
  • Levalbuterol

    the r-isomer of albuterol.
  • Nedocromil

    a pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils; neutrophils; macrophages; mast cells; monocytes; and platelets.
  • Terbutaline

    a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
  • Theophylline

    a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. theophylline inhibits the 3',5'-cyclic nucleotide phosphodiesterase that degrades cyclic amp thus potentiates the actions of agents that act through adenylyl cyclases and cyclic amp.
  • Tretoquinol

    an adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.

Coding Guidelines

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (T48). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Present on Admission (POA)

T48.6X2S is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA IndicatorReason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert T48.6X2S to ICD-9-CM

  • ICD-9-CM Code: 909.0 - Late eff drug poisoning
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.
  • ICD-9-CM Code: E959 - Late eff of self-injury
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.

Table of Drugs and Chemicals

The parent code T48.6X2 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Acefylline piperazineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AcepifyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AlbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AmbuphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AminophyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
AmlexanoxT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Antiasthmatic drug NECT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BambuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BamifyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BitolterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Bronchodilator NECT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BroxaterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BufrolinT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
BufyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ButetamateT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
CarbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
CholineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline
  »chloride
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline
  »dihydrogen citrate
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline
  »salicylate
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Choline
  »theophyllinate
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ClenbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ClorprenalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Cromoglicic acidT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
CromolynT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
DoxantrazoleT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EnprofyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EtafedrineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EtamiphyllinT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Ethylenediamine theophyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
EthylnorepinephrineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
FenoterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
FlunisolideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Flutropium bromideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Folium stramoniaeT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
GlyphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
HexoprenalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Ipratropium (bromide)T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IsoetarineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IsoprenalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
IsoproterenolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
LevalbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
LevoproxyphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
MethoxyphenamineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
NedocromilT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Oxitropium bromideT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
OxtriphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Pemirolast (potassium)T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
PirbuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ProtokylolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ProxyphyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
ReproterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
RimiterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
SalbutamolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
SalmeterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
StramoniumT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Stramonium
  »natural state
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TerbutalineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theobromine (calcium salicylate)T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theobromine (calcium salicylate)
  »sodium salicylate
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TheophyllamineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TheophyllineT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theophylline
  »aminobenzoic acid
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theophylline
  »ethylenediamine
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
Theophylline
  »piperazine p-amino-benzoate
T48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TretoquinolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6
TulobuterolT48.6X1T48.6X2T48.6X3T48.6X4T48.6X5T48.6X6

Patient Education


Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

  • Prescription or over-the-counter medicines taken in doses that are too high
  • Overdoses of illegal drugs
  • Carbon monoxide from gas appliances
  • Household products, such as laundry powder or furniture polish
  • Pesticides
  • Indoor or outdoor plants
  • Metals such as lead and mercury

The effects of poisoning range from short-term illness to brain damage, coma, and death. To prevent poisoning it is important to use and store products exactly as their labels say. Keep dangerous products where children can't get to them. Treatment for poisoning depends on the type of poison. If you suspect someone has been poisoned, call your local poison control center at 1-800-222-1222 right away.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.