2026 ICD-10-CM Diagnosis Code T46.0X5AAdverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter
T46.0X5A is a billable ICD-10-CM diagnosis code for adverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T46.0X5A.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to Digitalis glycoside
- Cardiac inotropic agent adverse reaction
- Digitoxin adverse reaction
- Digoxin adverse reaction
- Lanatoside C adverse reaction
- Medigoxin adverse reaction
- Ouabain adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Deslanoside
deacetyllanatoside c. a cardiotonic glycoside from the leaves of digitalis lanata.Acetyldigitoxins
cardioactive derivatives of lanatoside a or of digitoxin. they are used for fast digitalization in congestive heart failure.Digitoxin
a cardiac glycoside sometimes used in place of digoxin. it has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (from martindale, the extra pharmacopoeia, 30th ed, p665)Acetyldigoxins
alpha- or beta-acetyl derivatives of digoxin or lanatoside c from digitalis lanata. they are better absorbed and longer acting than digoxin and are used in congestive heart failure.Digoxin
a cardiotonic glycoside obtained mainly from digitalis lanata; it consists of three sugars and the aglycone digoxigenin. digoxin has positive inotropic and negative chronotropic activity. it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. its use in congestive heart failure and sinus rhythm is less certain. the margin between toxic and therapeutic doses is small. (from martindale, the extra pharmacopoeia, 30th ed, p666)Lanatosides
glycosides from digitalis lanata leaf. lanatoside c has actions similar to digoxin. mixtures of lanatosides a, b, and c have also been used. (from martindale, the extra pharmacopoeia, 30th ed, p670)Proscillaridin
a cardiotonic glycoside isolated from scilla maritima var. alba (squill).Strophanthus
a plant genus of the family apocynaceae that contains ouabain cardiac glycosides.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T46.0X5A to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T46.0X5AOverview
Is T46.0X5A a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character A in T46.0X5A mean?
The final character A marks the initial encounter: use it while the patient is receiving active treatment for adverse effect of cardiac-stimulant glycosides and drugs of similar action, such as an emergency visit or first evaluation.
What MS-DRG does T46.0X5A group to?
On inpatient claims, adverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter maps to MS-DRG 917, 918, with relative weights from 0.8571 to 1.5684 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T46.0X5A be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
What is the ICD-9 equivalent of T46.0X5A?
Under the General Equivalence Mappings, adverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter converts to ICD-9-CM 995.29 (adv eff med/biol NEC/NOS) and E942.1 (adv eff cardiotonics). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
