2026 ICD-10-CM Diagnosis Code T46.0X2APoisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter
T46.0X2A is a billable ICD-10-CM diagnosis code for poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 917 through 918. Coders also document this condition as cardiac inotropic agent overdose. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under External cause codes: intent of injury, self-harm; External cause codes: poisoning by drug; and Poisoning by drugs, initial encounter.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Cardiac inotropic agent overdose
- Digoxin overdose
- Intentional digoxin overdose
- Intentional digoxin poisoning
- Overdose of Digitalis glycoside
- Poisoning by Digitalis glycoside
- Poisoning by digoxin
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Deslanoside
deacetyllanatoside c. a cardiotonic glycoside from the leaves of digitalis lanata.Acetyldigitoxins
cardioactive derivatives of lanatoside a or of digitoxin. they are used for fast digitalization in congestive heart failure.Digitoxin
a cardiac glycoside sometimes used in place of digoxin. it has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (from martindale, the extra pharmacopoeia, 30th ed, p665)Acetyldigoxins
alpha- or beta-acetyl derivatives of digoxin or lanatoside c from digitalis lanata. they are better absorbed and longer acting than digoxin and are used in congestive heart failure.Digoxin
a cardiotonic glycoside obtained mainly from digitalis lanata; it consists of three sugars and the aglycone digoxigenin. digoxin has positive inotropic and negative chronotropic activity. it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. its use in congestive heart failure and sinus rhythm is less certain. the margin between toxic and therapeutic doses is small. (from martindale, the extra pharmacopoeia, 30th ed, p666)Lanatosides
glycosides from digitalis lanata leaf. lanatoside c has actions similar to digoxin. mixtures of lanatosides a, b, and c have also been used. (from martindale, the extra pharmacopoeia, 30th ed, p670)Proscillaridin
a cardiotonic glycoside isolated from scilla maritima var. alba (squill).Strophanthus
a plant genus of the family apocynaceae that contains ouabain cardiac glycosides.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Poisoning
A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T46.0X2A to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T46.0X2AOverview
Is T46.0X2A a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character A in T46.0X2A mean?
The final character A marks the initial encounter: use it while the patient is receiving active treatment for poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, such as an emergency visit or first evaluation.
What MS-DRG does T46.0X2A group to?
When poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 917, 918, with relative weights from 0.8571 to 1.5684 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of T46.0X2A?
Under the General Equivalence Mappings, poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter converts to ICD-9-CM 972.1 (poisoning-cardiotonics) and E950.4 (poison-drug/medicin NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
