2027 ICD-10-CM Diagnosis Code T39.395SAdverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], sequela
T39.395S is a billable ICD-10-CM diagnosis code for adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T39.395S.
Present on Admission (POA)Billing
T39.395S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50).
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acemetacin adverse reaction
- Acquired pancytopenia
- Adverse reaction to diclofenac sodium
- Adverse reaction to fenbufen
- Adverse reaction to mefenamic acid
- Adverse reaction to piroxicam
- Allergic contact dermatitis caused by drug in contact with skin
- Allergic reaction caused by analgesic
- Allergic reaction caused by nonsteroidal antiinflammatory agent
- Anaphylaxis caused by analgesic
- Anaphylaxis caused by non-steroidal anti-inflammatory agent
- Delayed photoallergic dermatitis
- Diclofenac adverse reaction
- Drug-aggravated angioedema-urticaria
- Drug-induced anaphylaxis
- Drug-induced angioedema-urticaria
- Drug-induced colitis
- Drug-induced enteritis of intestine
- Duodenal ulcer caused by bacterium
- Duodenal ulcer caused by drug
- Duodenal ulcer caused by Helicobacter pylori
- Duodenal ulcer caused by Helicobacter pylori and non-steroidal anti-inflammatory agent
- Duodenal ulcer caused by non-steroidal anti-inflammatory drug
- Etodolac adverse reaction
- Felbinac adverse reaction
- Gastric ulcer caused by bacterium
- Gastric ulcer caused by drug
- Gastric ulcer caused by Helicobacter pylori
- Gastric ulcer caused by Helicobacter pylori and non-steroidal anti-inflammatory agent
- Gastric ulcer caused by non-steroidal anti-inflammatory drug in therapeutic use
- Gastritis medicamentosa
- Indomethacin adverse reaction
- Indomethacin embryofetopathy
- Nabumetone adverse reaction
- Non-allergic anaphylaxis caused by drug
- Non-allergic anaphylaxis caused by non steroidal anti-inflammatory drug
- Non-steroidal anti-inflammatory drug adverse reaction
- Non-steroidal anti-inflammatory drug exacerbated respiratory disease
- Non-steroidal anti-inflammatory drug-induced colitis
- Non-steroidal anti-inflammatory drug-induced enteropathy
- NSAID -aggravated angioedema-urticaria
- NSAID-associated gastropathy
- NSAID-induced angioedema-urticaria
- Pancytopenia caused by medication
- Pancytopenia caused by non-steroidal anti-inflammatory agent
- Photoallergic contact dermatitis due to non-steroidal anti-inflammatory drug
- Photoallergic dermatitis
- Sulindac adverse reaction
- Tenoxicam adverse reaction
- Tolmetin adverse reaction
- Urticaria medicamentosa
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (T39). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to T39.395S: its own notes plus those printed at T39, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify any retained foreign body, if applicable (Z18.-)
Notes
General instructions on how these codes are used.
- Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
- The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.
7th Character
Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.
- The appropriate 7th character is to be added to each code from category T39
- Ainitial encounter
- Dsubsequent encounter
- Ssequela this code
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name T39.395S, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming T39.395S: its condition is not part of those codes, and both may be reported when the patient has both.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T39.395S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T39.395SOverview
Is T39.395S a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], sequela on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What does the 7th character S in T39.395S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID] itself has resolved, not the original event.
What MS-DRG does T39.395S group to?
On inpatient claims, adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], sequela maps to MS-DRG 923, 922, with relative weights from 0.9980 to 1.6248 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T39.395S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T39.395S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], sequela on inpatient claims. The code appears in the Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50) range of the CMS exempt list.
