2024 ICD-10-CM Diagnosis Code T39.395A

Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], initial encounter

ICD-10-CM Code:
T39.395A
ICD-10 Code for:
Adverse effect of nonsteroidal anti-inflammatory drugs, init
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics
        (T39)

T39.395A is a billable diagnosis code used to specify a medical diagnosis of adverse effect of other nonsteroidal anti-inflammatory drugs [nsaid], initial encounter. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

T39.395A is an initial encounter code, includes a 7th character and should be used while the patient is receiving active treatment for a condition like adverse effect of other nonsteroidal anti-inflammatory drugs [nsaid]. According to ICD-10-CM Guidelines an "initial encounter" doesn't necessarily means "initial visit". The 7th character should be used when the patient is undergoing active treatment regardless if new or different providers saw the patient over the course of a treatment. The appropriate 7th character codes should also be used even if the patient delayed seeking treatment for a condition.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acemetacin adverse reaction
  • Adverse reaction to diclofenac sodium
  • Adverse reaction to fenbufen
  • Adverse reaction to mefenamic acid
  • Adverse reaction to piroxicam
  • Allergic contact dermatitis due to drug in contact with skin
  • Allergic reaction caused by analgesic
  • Allergic reaction caused by nonsteroidal antiinflammatory agent
  • Delayed photoallergic dermatitis
  • Diclofenac adverse reaction
  • Drug-induced angioedema-urticaria
  • Drug-induced colitis
  • Drug-induced enteritis of intestine
  • Duodenal ulcer caused by bacterium
  • Duodenal ulcer caused by drug
  • Duodenal ulcer caused by drug
  • Duodenal ulcer caused by Helicobacter pylori
  • Duodenal ulcer caused by Helicobacter pylori and non-steroidal anti-inflammatory agent
  • Duodenal ulcer caused by non-steroidal anti-inflammatory drug
  • Duodenal ulcer caused by non-steroidal anti-inflammatory drug
  • Etodolac adverse reaction
  • Felbinac adverse reaction
  • Gastric ulcer caused by bacterium
  • Gastric ulcer caused by drug
  • Gastric ulcer caused by drug
  • Gastric ulcer caused by Helicobacter pylori and non-steroidal anti-inflammatory agent
  • Gastric ulcer caused by non-steroidal anti-inflammatory drug in therapeutic use
  • Gastric ulcer caused by non-steroidal anti-inflammatory drug in therapeutic use
  • Gastric ulcer due to Helicobacter pylori
  • Gastritis medicamentosa
  • Indomethacin adverse reaction
  • Indomethacin embryofetopathy
  • Nabumetone adverse reaction
  • Non-allergic anaphylaxis caused by drug
  • Non-allergic anaphylaxis caused by non steroidal anti-inflammatory drug
  • Non-steroidal anti-inflammatory drug adverse reaction
  • Non-steroidal anti-inflammatory drug-induced colitis
  • Non-steroidal anti-inflammatory drug-induced enteropathy
  • Non-steroidal anti-inflammatory drug-induced enteropathy
  • Non-steroidal anti-inflammatory drug-induced enteropathy
  • Non-steroidal anti-inflammatory drug-induced enteropathy
  • NSAID-associated gastropathy
  • NSAID-induced angioedema-urticaria
  • Photo-allergic contact dermatitis due to non-steroidal anti-inflammatory drug
  • Photoallergic dermatitis
  • Sulindac adverse reaction
  • Tenoxicam adverse reaction
  • Tolmetin adverse reaction
  • Urticaria medicamentosa

Clinical Classification

Clinical Information

  • Diclofenac

    a non-steroidal anti-inflammatory agent (nsaid) with antipyretic and analgesic actions. it is primarily available as the sodium salt.
  • Etodolac

    a non-steroidal anti-inflammatory agent and cyclooxygenase-2 (cox-2) inhibitor with potent analgesic and anti-arthritic properties. it has been shown to be effective in the treatment of osteoarthritis; rheumatoid arthritis; ankylosing spondylitis; and in the alleviation of postoperative pain (pain, postoperative).
  • Flufenamic Acid

    an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. it is used in musculoskeletal and joint disorders and administered by mouth and topically. (from martindale, the extra pharmacopoeia, 30th ed, p16)
  • Indomethacin

    a non-steroidal anti-inflammatory agent (nsaid) that inhibits cyclooxygenase, which is necessary for the formation of prostaglandins and other autacoids. it also inhibits the motility of polymorphonuclear leukocytes.
  • Meclofenamic Acid

    a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. it also inhibits prostaglandin biosynthesis.
  • Mefenamic Acid

    a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. it is an inhibitor of cyclooxygenase.
  • Nabumetone

    a butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (cox2) inhibitor that is used in the management of pain associated with osteoarthritis and rheumatoid arthritis.
  • Piroxicam

    a cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (nsaid) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. its long half-life enables it to be administered once daily.
  • Sulindac

    a sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active nsaid analgesic. specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. this helps to maintain constant blood levels with reduced gastrointestinal side effects.
  • Tolmetin

    a non-steroidal anti-inflammatory agent (anti-inflammatory agents, non-steroidal) similar in mode of action to indomethacin.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (T39). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10-CM Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Convert T39.395A to ICD-9-CM

  • ICD-9-CM Code: 995.29 - Adv eff med/biol NEC/NOS
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.
  • ICD-9-CM Code: E935.7 - Adv eff non-narc analgsc
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.

Table of Drugs and Chemicals

The parent code T39.395 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Anti-inflammatory drug NECT39.391T39.392T39.393T39.394T39.395T39.396
Anti-inflammatory drug NEC
  »local
T39.391T39.392T39.393T39.394T39.395T39.396
Anti-inflammatory drug NEC
  »nonsteroidal NEC
T39.391T39.392T39.393T39.394T39.395T39.396
Anti-inflammatory drug NEC
  »nonsteroidal NEC
    »propionic acid derivative
T39.391T39.392T39.393T39.394T39.395T39.396
Anti-inflammatory drug NEC
  »specified NEC
T39.391T39.392T39.393T39.394T39.395T39.396
DiclofenacT39.391T39.392T39.393T39.394T39.395T39.396
EtodolacT39.391T39.392T39.393T39.394T39.395T39.396
FenflumizoleT39.391T39.392T39.393T39.394T39.395T39.396
Flufenamic acidT39.391T39.392T39.393T39.394T39.395T39.396
IndometacinT39.391T39.392T39.393T39.394T39.395T39.396
IndomethacinT39.391T39.392T39.393T39.394T39.395T39.396
Indomethacin
  »farnesil
T39.391T39.392T39.393T39.394T39.395T39.396
IsoxicamT39.391T39.392T39.393T39.394T39.395T39.396
MeclofenamateT39.391T39.392T39.393T39.394T39.395T39.396
Meclofenamic acidT39.391T39.392T39.393T39.394T39.395T39.396
Mefenamic acidT39.391T39.392T39.393T39.394T39.395T39.396
NabumetoneT39.391T39.392T39.393T39.394T39.395T39.396
NimesulideT39.391T39.392T39.393T39.394T39.395T39.396
PiroxicamT39.391T39.392T39.393T39.394T39.395T39.396
Piroxicam
  »beta-cyclodextrin complex
T39.391T39.392T39.393T39.394T39.395T39.396
ProquazoneT39.391T39.392T39.393T39.394T39.395T39.396
SulindacT39.391T39.392T39.393T39.394T39.395T39.396
TenoxicamT39.391T39.392T39.393T39.394T39.395T39.396
TolmetinT39.391T39.392T39.393T39.394T39.395T39.396
UfenamateT39.391T39.392T39.393T39.394T39.395T39.396
ZomepiracT39.391T39.392T39.393T39.394T39.395T39.396

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Pain Relievers

Pain relievers are medicines that reduce or relieve headaches, sore muscles, arthritis, or other aches and pains. There are many different pain medicines, and each one has advantages and risks. Some types of pain respond better to certain medicines than others. Each person may also have a slightly different response to a pain reliever.

Over-the-counter (OTC) medicines are good for many types of pain. There are two main types of OTC pain medicines: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs.

If OTC medicines don't relieve your pain, your doctor may prescribe something stronger. Many NSAIDs are also available at higher prescription doses. The most powerful pain relievers are opioids. They are very effective, but they can sometimes have serious side effects. There is also a risk of addiction. Because of the risks, you must use them only under a doctor's supervision.

There are many things you can do to help ease pain. Pain relievers are just one part of a pain treatment plan.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.