2027 ICD-10-CM Diagnosis Code Q87.81Alport syndrome

ICD-10-CM Codes›Q00-Q99›Q80-Q89›Q87

ICD-10-CM Q87.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Q87.81 is a billable ICD-10-CM diagnosis code for alport syndrome. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 564 through 566. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 40 closely related codes. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified congenital anomalies.

Code Identity

ICD-10-CM Code
Q87.81
Billable Status
Yes — Valid for Submission
Code Describes
Alport syndrome
Short Description
Alport syndrome
Same as the full description in the CMS dataset.
Parent Code
Q87.8
Other specified congenital malformation syndromes, not elsewhere classified

Code Classification

ChapterQ00-Q99Congenital malformations, deformations and chromosomal abnormalities
SectionQ80-Q89Other congenital malformations
CategoryQ87Other specified congenital malformation syndromes affecting multiple systems
This CodeQ87.81Alport syndrome

Present on Admission (POA)Billing

Q87.81 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Other congenital malformations (Q80-Q89).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alport syndrome
  • Alport syndrome autosomal dominant
  • Alport syndrome autosomal recessive
  • Alport syndrome X-linked
  • Alport syndrome, intellectual disability, midface hypoplasia, elliptocytosis syndrome
  • Collagen IV nephropathy
  • Congenital nephritis
  • Glomerular disease due to Alport syndrome
  • Hereditary elliptocytosis
  • X-linked diffuse leiomyomatosis with Alport syndrome
  • X-linked sensorineural hearing loss

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Q87.81: its own notes plus those printed at Q87.8, Q87, and Chapter 17. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Q87.8 Other specified congenital malformation syndromes, not elsewhere classified applies to 9 codes

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 17 (Q00-QA1) Congenital malformations, deformations and chromosomal abnormalities applies to 900 codes
  • inborn errors of metabolism (E70-E88)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

On Q87.81 itself
  • code to identify stage of chronic kidney disease (N18.1-N18.6)
From Q87 Other specified congenital malformation syndromes affecting multiple systems applies to 21 codes
  • code(s) to identify all associated manifestations

Notes

General instructions on how these codes are used.

From Chapter 17 (Q00-QA1) Congenital malformations, deformations and chromosomal abnormalities applies to 900 codes
  • Codes from this chapter are not for use on maternal records

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Q87.81, its category, or a range that includes it.

Excludes1 3

These codes carry an Excludes1 note naming Q87.81: they are not reported together with it, unless the two conditions are unrelated.

  • Q67 Congenital musculoskeletal deformities of head, face, spine and chest
    congenital malformation syndromes classified to Q87.- names Q87.-, which includes this code
  • Q75 Other congenital malformations of skull and face bones
    congenital malformation syndromes classified to Q87.- names Q87.-, which includes this code
  • Q89.7 Multiple congenital malformations, not elsewhere classified
    congenital malformation syndromes affecting multiple systems (Q87.-) names Q87.-, which includes this code

Excludes2 1

These codes carry an Excludes2 note naming Q87.81: its condition is not part of those codes, and both may be reported when the patient has both.

  • N07 Hereditary nephropathy, not elsewhere classified
    Alport's syndrome (Q87.81-)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MAL010
Other specified and unspecified congenital anomalies
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Alport Syndrome

    a genetic syndrome usually inherited as an x-link trait. it is caused by abnormalities in the col4a5 gene. it affects males more often than females and is characterized by hematuria, progressive renal insufficiency, hearing loss, and ocular abnormalities.

Patient EducationClinical

Birth Defects

A birth defect is a problem that happens while a baby is developing in the mother's body. Most birth defects happen during the first 3 months of pregnancy. One out of every 33 babies in the United States is born with a birth defect.

The full article covers:

  • What are birth defects?
  • What causes birth defects?
  • Who is at risk of having a baby with birth defects?
  • How are birth defects diagnosed?
  • What are the treatments for birth defects?
  • Can birth defects be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Q87.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
759.89 Specfied cong anomal NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Q87.81Overview

What is the ICD-10 code for alport syndrome?

The ICD-10-CM code for alport syndrome is Q87.81 (sometimes written as Q8781). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is Q87.81 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report alport syndrome on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Q87.81 group to?

When alport syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 564, 566, 565, with relative weights from 0.7374 to 1.4909 depending on complications. Higher weights mean higher Medicare reimbursement.

Is Q87.81 a CC or MCC?

CMS lists Q87.81 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 40 closely related codes in its exclusion list.

Is Q87.81 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for alport syndrome on inpatient claims. The code appears in the Other congenital malformations (Q80-Q89) range of the CMS exempt list.