2026 ICD-10-CM Diagnosis Code Q78.0Osteogenesis imperfecta

ICD-10-CM Codes›Q00-Q99›Q65-Q79›Q78

ICD-10-CM Q78.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Q78.0 is a billable ICD-10-CM diagnosis code for osteogenesis imperfecta. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 456 through 458, 564 through 566. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Musculoskeletal congenital conditions.

Code Identity

ICD-10-CM Code
Q78.0
Billable Status
Yes — Valid for Submission
Code Describes
Osteogenesis imperfecta
Short Description
Osteogenesis imperfecta
Same as the full description in the CMS dataset.
Parent Code
Q78
Other osteochondrodysplasias

Code Classification

ChapterQ00-Q99Congenital malformations, deformations and chromosomal abnormalities
SectionQ65-Q79Congenital malformations and deformations of the musculoskeletal system
CategoryQ78Other osteochondrodysplasias
This CodeQ78.0Osteogenesis imperfecta

Present on Admission (POA)Billing

Q78.0 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal blue sclerae
  • Congenital anomaly of sclera
  • Dentinogenesis imperfecta
  • Doughnut lesion of calvaria and bone fragility syndrome
  • Ehlers-Danlos and osteogenesis imperfecta syndrome
  • Grange syndrome
  • Hereditary dysplasia of blood vessel
  • High bone mass osteogenesis imperfecta
  • Osteogenesis imperfecta
  • Osteogenesis imperfecta type 5
  • Osteogenesis imperfecta type I
  • Osteogenesis imperfecta type IIA
  • Osteogenesis imperfecta type IIB
  • Osteogenesis imperfecta type IIC
  • Osteogenesis imperfecta type III
  • Osteogenesis imperfecta with blue sclerae AND dentinogenesis imperfecta
  • Osteogenesis imperfecta with blue sclerae AND normal teeth
  • Osteogenesis imperfecta with normal sclerae, dominant form
  • Osteogenesis imperfecta, dominant perinatal lethal
  • Osteogenesis imperfecta, perinatal lethal
  • Osteogenesis imperfecta, recessive perinatal lethal
  • Osteogenesis imperfecta, recessive perinatal lethal, with microcephaly AND cataracts
  • Osteogenesis imperfecta, retinopathy, seizures, intellectual disability syndrome
  • Osteogenesis imperfecta, type IV A
  • Osteogenesis imperfecta, type IV B
  • Osteoporosis with pseudoglioma

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Fragilitas ossium
  • Osteopsathyrosis

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adair-Dighton syndrome(brittle bones and blue sclera, deafness)
    • Blue
      • sclera
        • with fragility of bone and deafness
    • Brittle
      • bones disease
    • Deafness(acquired) (complete) (hereditary) (partial)
      • with blue sclera and fragility of bone
    • Deafness(acquired) (complete) (hereditary) (partial)
      • congenital
        • with blue sclera and fragility of bone
    • Disease, diseased
      • Eddowes' (brittle bones and blue sclera)
    • Disease, diseased
      • Lobstein's (brittle bones and blue sclera)
    • Disease, diseased
      • Vrolik's (osteogenesis imperfecta)
    • Eddowes(-Spurway) syndrome
    • Ekman's syndrome(brittle bones and blue sclera)
    • Fragile, fragility
      • bone, congenital (with blue sclera)
    • Fragilitas
      • ossium (with blue sclerae) (hereditary)
    • Lobstein(-Ekman) disease or syndrome
    • Osteitis
      • fragilitans
    • Osteogenesis imperfecta
    • Osteopsathyrosis(idiopathica)
    • Spurway's syndrome
    • Syndrome
      • Adair-Dighton
    • Syndrome
      • blue sclera
    • Syndrome
      • Dighton's
    • Syndrome
      • Eddowes'
    • Syndrome
      • Ekman's
    • Syndrome
      • Spurway's
    • Syndrome
      • van der Hoeve's
    • Van der Hoeve(-de Kleyn) syndrome
    • Vrolik's disease

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MAL008
Musculoskeletal congenital conditions
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Osteogenesis Imperfecta

    collagen diseases characterized by brittle, osteoporotic, and easily fractured bones. it may also present with blue sclerae, loose joints, and imperfect dentin formation. most types are autosomal dominant and are associated with mutations in collagen type i.

  • Dentinogenesis Imperfecta

    an autosomal dominant disorder of tooth development characterized by opalescent dentin resulting in discoloration of the teeth. the dentin develops poorly with low mineral content while the pulp canal is obliterated.

  • COL1A2 wt Allele|COL1A2|Collagen Type I Alpha 2 Chain wt Allele|Collagen of Skin, Tendon and Bone, Alpha-2 Chain Gene|Collagen, Type I, Alpha 2 Gene|Collagen, Type I, Alpha-2 Gene|EDSARTH2|EDSCV|OI4|Osteogenesis Imperfecta Type IV Gene

    human col1a2 wild-type allele is located in the vicinity of 7q22.1 and is approximately 37 kb in length. this allele, which encodes collagen alpha-2 (i) chain protein, plays a role in the structural integrity of tendons, ligaments and bones. mutations in the gene are associated with atypical marfan syndrome, ehlers-danlos syndrome types and osteogenesis imperfecta types.

  • Dentinogenesis Imperfecta

    a congenital tooth development disorder caused by mutations in the dspp gene. the teeth are weak, discolored, and translucent.

  • COL1A2 wt Allele|COL1A2|Collagen Type I Alpha 2 Chain wt Allele|Collagen, Type I, Alpha 2 Gene|OI4|Osteogenesis Imperfecta Type IV Gene

    human col1a2 wild-type allele is located in the vicinity of 7q22.1 and is approximately 37 kb in length. this allele, which encodes collagen alpha-2 (i) chain protein, plays a role in the structural integrity of tendons, ligaments and bones. mutations in the gene are associated with atypical marfan syndrome, ehlers-danlos syndrome types and osteogenesis imperfecta types.

  • Osteogenesis Imperfecta Type I

    the mildest and most common type of osteogenesis imperfecta. it is characterized by bone fractures, muscle weakness, and loose joints. bone deformities are either absent or minimal.

  • Osteogenesis Imperfecta Type II

    a severe form of osteogenesis imperfecta. it is characterized by bone deformities, multiple fractures, underdeveloped lungs, and often death during or after birth due to respiratory abnormalities.

  • Osteogenesis Imperfecta Type III

    a type of osteogenesis imperfecta characterized by bone fractures, bone deformities, short stature, poor muscle development, barrel-shaped chest, and triangular face.

  • Osteogenesis Imperfecta Type IV

    a type of osteogenesis imperfecta that is characterized by fractures and hearing loss. it is more severe than type i and less severe than types ii and iii.

Patient EducationClinical

Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a genetic disorder in which bones fracture (break) easily. Sometimes the fractures happen for no known reason. OI can also cause weak muscles, brittle teeth, a curved spine, and hearing loss. OI is caused by one of several genes that aren't working properly.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Q78.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
756.51 Osteogenesis imperfecta
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Q78.0Overview

Is Q78.0 (Other osteochondrodysplasias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report osteogenesis imperfecta on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does Q78.0 group to?

When osteogenesis imperfecta is the principal diagnosis on an inpatient stay, it groups to MS-DRG 456, 457, 458, 564, 565, 566, with relative weights from 0.7493 to 8.4034 depending on complications. Higher weights mean higher Medicare reimbursement.

Is Q78.0 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for osteogenesis imperfecta on inpatient claims.

What is the ICD-9 equivalent of Q78.0?

Under the General Equivalence Mappings, osteogenesis imperfecta converts to ICD-9-CM 756.51 (osteogenesis imperfecta). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.