2024 ICD-10-CM Diagnosis Code Q78.8

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Acrocapitofemoral dysplasia
• Acrodysostosis
• Acromesomelic dysplasia Hunter-Thompson type
• Acromesomelic dysplasia Maroteaux type
• Acroosteolysis
• Acroosteolysis
• Acroosteolysis
• Acropectorovertebral dysplasia
• Agenesis of fibula
• Aluminum bone disease
• Aluminum-related fracturing osteodystrophy
• Angel-shaped phalangoepiphyseal dysplasia
• Atelosteogenesis
• Atelosteogenesis type 1
• Atelosteogenesis type 2
• Atelosteogenesis type 3
• Autosomal dominant omodysplasia
• Autosomal dominant retinitis pigmentosa
• Autosomal recessive omodysplasia
• Beals auriculo-osteodysplasia syndrome
• Bent bone dysplasia group
• Blomstrand dysplasia
• Bone dysplasia lethal Holmgren type
• Boomerang dysplasia
• Bowing of upper limb
• Bruck syndrome
• Carpal-tarsal osteolysis with nephropathy
• Carpotarsal osteochondromatosis
• Cerebral degeneration in childhood
• Chitty Hall Baraitser syndrome
• Chronic deafness
• CHST3-related skeletal dysplasia
• Cleidorhizomelic syndrome
• Cole-Carpenter dysplasia
• Colobomatous microphthalmia, rhizomelic dysplasia syndrome
• Complex lethal osteochondrodysplasia
• Congenital abnormal fusion of humerus
• Congenital abnormal shape of humerus
• Congenital abnormal shape of radius
• Congenital absence of pectoral muscle
• Congenital anomalies of elbow and upper arm
• Congenital deformity of bone of forearm
• Congenital exostosis
• Congenital hypoplasia of fibula
• Congenital hypoplasia of tibia
• Congenital hypoplasia of ulna
• Congenital nephritis
• Congenital progressive bone marrow failure, B-cell immunodeficiency, skeletal dysplasia syndrome
• Craniofrontonasal dysplasia with Poland anomaly syndrome
• Craniometadiaphyseal dysplasia
• Craniometadiaphyseal dysplasia wormian bone type
• Craniometaphyseal dysplasia
• Dacryocystitis and osteopoikilosis syndrome
• Dappled diaphyseal dysplasia
• Deafness, genital anomaly, metacarpal and metatarsal synostosis syndrome
• Deformity of radius
• Dermatofibrosis lenticularis disseminata
• Desbuquois syndrome
• Diaphanospondylodysostosis
• Disorganized development of cartilaginous and fibrous components of the skeleton
• Disuse osteodystrophy
• Dyschondrosteosis and nephritis syndrome
• Dysosteosclerosis
• Dysostosis
• Dysplasia with defective mineralization
• Dysplasia with increased bone density
• Dysplasias with significant membranous bone involvement
• Dysplastic cortical hyperostosis
• Early-onset calcifying leukoencephalopathy, skeletal dysplasia
• Enchondromatosis
• Endocrine-cerebro-osteodysplasia syndrome
• Endosteal hyperostoses
• Endosteal hyperostoses
• Endosteal hyperostoses with cerebellar hypoplasia
• Epilepsy, microcephaly, skeletal dysplasia syndrome
• Epiphyseal dysplasia
• Epiphyseal dysplasia, hearing loss, dysmorphism syndrome
• Epiphyseal dysplasia, microcephalus, nystagmus syndrome
• Familial osteodysplasia Anderson type
• FGFR2-related bent bone dysplasia
• Fibrochondrogenesis
• Frontometaphyseal dysplasia
• Frontonasal dysplasia sequence
• Geleophysic dysplasia
• Genochondromatosis
• Genochondromatosis type 1
• Genochondromatosis type 2
• Giacci familial neurogenic acroosteolysis
• Gnathodiaphyseal dysplasia
• Grant syndrome
• Hair discoloration
• Hajdu-Cheney syndrome
• Heide syndrome
• Hepatic osteodystrophy
• Hereditary acroosteolysis
• Humeroulnar synostosis
• Hyperphosphatasemia tarda
• Idiopathic hypoparathyroidism
• Idiopathic osteolyses
• Idiopathic osteolyses
• Immuno-osseous dysplasia
• Immuno-osseous dysplasia
• Immuno-osseous dysplasia
• Immuno-osseous dysplasia
• Infantile cortical hyperostosis
• Isolated osteopoikilosis
• Kenny syndrome
• Kniest dysplasia
• Kniest-Stickler dysplasia
• Kyphomelic dysplasia
• Larsen-like osseous dysplasia, short stature syndrome
• Larsen-like syndrome B3GAT3 type
• Lenz-Majewski hyperostosis syndrome
• Leri's pleonosteosis syndrome
• Lethal chondrodysplasia with fragmented bone
• Lethal Kniest-like syndrome
• Lethal occipital encephalocele, skeletal dysplasia syndrome
• Lethal recessive chondrodysplasia
• Leukoencephalopathy with metaphyseal chondrodysplasia syndrome
• Longitudinal deficiency of foot
• LRP5-related primary osteoporosis
• Madelung's deformity
• Melhem Fahl syndrome
• Melnick-Needles syndrome
• Melorheostosis
• Melorheostosis with osteopoikilosis
• Mesomelic dysplasia
• Mesomelic dysplasia Kantaputra type
• Mesomelic dysplasia of upper limb
• Mesomelic dysplasia Savarirayan type
• Metachondromatosis
• Metaphyseal anadysplasia
• Metaphyseal chondrodysplasia Kaitila type
• Metatropic dysplasia
• Microcephalic osteodysplastic dysplasia Saul Wilson type
• Microcephalic osteodysplastic primordial dwarfism type II
• Microcephalic osteodysplastic primordial dwarfism types I and III
• Mixed sclerosing bone dysplasia
• Mixed sclerosing bone dystrophy with extra-skeletal manifestation
• Multiple dislocations with dysplasia
• Multiple epiphyseal dysplasia
• Multiple epiphyseal dysplasia due to collagen 9 anomaly
• Multiple epiphyseal dysplasia Lowry type
• Multiple epiphyseal dysplasia tarda type IIIa
• Multiple epiphyseal dysplasia type 1
• Multiple epiphyseal dysplasia type 4
• Multiple epiphyseal dysplasia type 5
• Multiple epiphyseal dysplasia with miniepiphyses
• Multiple epiphyseal dysplasia with severe proximal femoral dysplasia
• Multiple synostosis syndrome
• NEK9-related lethal skeletal dysplasia
• Neonatal osteosclerotic dysplasia
• Occipital encephalocele
• Omodysplasia
• Osteochondrodysplatic nanism, deafness, retinitis pigmentosa syndrome
• Osteochondroma of bone
• Osteocraniostenosis
• Osteodysplastic dysplasia, type I
• Osteodysplastic dysplasia, type II
• Osteodysplastic primordial dwarfism
• Osteodysplastic primordial dwarfism
• Osteodysplastic primordial dwarfism
• Osteodysplastic primordial dwarfism
• Osteofibrous dysplasia
• Osteoglophonic dysplasia
• Osteopathia striata
• Osteopathia striata
• Osteopathia striata, pigmentary dermopathy, white forelock syndrome
• Osteoplastic dysplasia
• Osteoplastic dysplasia
• Osteopoikilosis
• Osteopoikilosis
• Osteopoikilosis
• Otopalatodigital syndrome spectrum disorder
• Otopalatodigital syndrome spectrum disorder
• Otopalatodigital syndrome spectrum disorder
• Pachydermoperiostosis - familial
• Pacman dysplasia
• Peripheral dysostosis
• Poland anomaly
• Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
• Precocious osteodysplasty
• Progressive pseudorheumatoid dysplasia
• Pseudodiastrophic dysplasia
• Pyknoachondrogenesis
• Pyknodysostosis
• QRICH1-related intellectual disability, chondrodysplasia syndrome
• Raine dysplasia
• Reardon Hall Slaney syndrome
• Reinhardt Pfeiffer mesomelic dysplasia
• Rhizomelic dysplasia Patterson Lowry type
• Rhizomelic syndrome Urbach type
• RHYNS syndrome
• Rolland-Debuqois syndrome
• Schimke immuno-osseous dysplasia
• Sclerosteosis
• SHOX-related short stature
• Skeletal dysplasia with epilepsy and short stature syndrome
• Skeletal dysplasia, T-cell immunodeficiency, developmental delay syndrome
• Smith McCort dysplasia
• Spondylocarpotarsal synostosis syndrome
• Spondylodysplasia, Luton type
• Spondylodysplasia, San Diego type
• Spondylodysplasia, Torrance type
• Spondylodysplastic group
• Spondyloenchondrodysplasia
• Spondyloenchondrodysplasia with immune dysregulation
• Spondyloepimetaphyseal dysplasia, Strudwick type
• Spondyloepiphyseal dysplasia with congenital joint dislocations
• Spondylometaphyseal dysplasia Schmidt type
• Spondylometaphyseal dysplasia with cone-rod dystrophy syndrome
• Spondylo-ocular syndrome
• Stenosis of lacrimal canaliculi
• Stuve-Wiedemann dysplasia
• Syndromic nanophthalmos due to Kenny-Caffey syndrome
• Terminal osseous dysplasia and pigmentary defect syndrome
• Variation in hair color
• Velofacioskeletal syndrome
• Weismann Netter syndrome
• White forelock
• Whyte Hemingway carpal tarsal phalangeal osteolyses
• X-linked calvarial hyperostosis
• X-linked dominant chondrodysplasia Chassaing Lacombe type
• X-linked osteoporosis with fractures
• Yunis-Varon dysplasia

Clinical Information

• Enchondromatosis

  benign growths of cartilage in the metaphyses of several bones.

• Melorheostosis

  a form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.

• Osteopoikilosis

  an asymptomatic, autosomal dominant trait in which pea-sized sclerotic spots, prominent in the metaphyseal area, are accompanied by unique cutaneous lesions. these are yellowish papules or plaques with increased elastin content. (from cecil textbook of medicine, 19th ed, pp1434-35)

• Acrodysostosis 1|ACRDYS1

  an autosomal dominant skeletal dysplasia caused by mutation(s) in the prkar1a gene, encoding camp-dependent protein kinase type i-alpha regulatory subunit. it is characterized by short stature, brachydactyly, and characteristic facial features. resistance to multiple hormones is a common finding.

• Cleidocranial Dysplasia|Cleidocranial Dysostosis|Cleidocranial Dysostosis

  a rare autosomal dominant disorder caused by mutations in the runx2 gene. it is characterized by developmental abnormalities in the bones and teeth, including the complete or partial absence of the clavicles, delayed closure of the fontanels, protruding mandible, hypertelorism, scoliosis, and short stature.

• Craniofacial Dysostosis|Crouzon Syndrome|Crouzon Syndrome

  a syndrome inherited in an autosomal dominant pattern. it is characterized by early fusion of the bones of the skull and face. patients have a distinctive facial appearance which includes low-set ears, brachycephaly, hypertelorism, exophthalmos, and mandibular prognathism.

• CTSK wt Allele|CTS02|CTSO|CTSO1|CTSO2|Cathepsin K (Pycnodysostosis) Gene|Cathepsin K wt Allele|Cathepsin O1 Gene|MGC23107|PKND|PYCD

  human ctsk wild-type allele is located in the vicinity of 1q21 and is approximately 12 kb in length. this allele, which encodes cathepsin k protein, plays a role in the regulation of both proteolysis and osteoclastic bone resorption. mutation of the gene is associated with pycnodysostosis.

• Dysostosis

  a defect in ossification of bone.

• FGFR2 wt Allele|BBDS|BEK|BEK Fibroblast Growth Factor Receptor Gene|BEK, Mouse, Homology of Gene|BFR-1|Bacteria-Expressed Kinase Gene|CD332|CEK3|CFD1|Craniofacial Dysostosis Gene|Crouzon Syndrome Gene|ECT1|FGFR2|Fibroblast Growth Factor Receptor 2 wt Allele|Fibroblast Growth Factor Receptor BEK Gene|JWS|Jackson-Weiss Syndrome Gene|K-SAM|KGFR Gene|KSAM-1|Keratinocyte Growth Factor Receptor Gene|Pfeiffer Syndrome Gene|Protein Tyrosine Kinase, Receptor-Like, 14 Gene|TK14|TK25

  human fgfr2 wild-type allele is located within 10q26 and is approximately 875 kb in length. this allele, which encodes fibroblast growth factor receptor 2 protein, plays a role in mitogenesis and differentiation by mediating the binding interactions of keratinocyte growth factor. mutations in the gene are associated with crouzon syndrome, pfeiffer syndrome, craniosynostosis, apert syndrome, jackson-weiss syndrome, beare-stevenson cutis gyrata syndrome, saethre-chotzen syndrome, and syndromic craniosynostosis.

• Pycnodysostosis

  an autosomal recessive disorder caused by loss-of-function mutation(s) in the ctsk gene, encoding cathepsin k, an enzyme involved in bone resorption by osteoclasts. this condition is characterized by some or all of the following: osteosclerosis, short stature, pituitary hypoplasia with growth hormone deficiency, and cerebral demyelination.

• Spondylocostal Dysostosis

  a rare disorder caused by mutations in the dll3 gene, mesp2 gene, lfng gene, or hes7 gene. it is characterized by abnormal development of bones in the spine and ribs.

• Treacher Collins Syndrome|Mandibulofacial Dysostosis

  a rare autosomal dominant syndrome caused by mutations in the tcof1 gene. its characteristics include underdevelopment of the facial bones, small jaw and chin, absent or small ears, defects in the middle ear resulting in hearing loss, and downward sloping palpebral fissures.

• Metatropic Dysplasia

  an autosomal dominant condition caused by mutation(s) in the trpv4 gene, encoding transient receptor potential cation channel subfamily v member 4. it is characterized by a variable phenotype, which may include short limbs, kyphoscoliosis, and other skeletal abnormalities.

• Acroosteolysis

  a condition that is characterized by degeneration of the distal phalanges.

• Melorheostosis

  a very rare bone disorder characterized by thickening of the cortex in a linear pattern. signs and symptoms include joint pain, joint swelling, limb deformity, and changes in the skin covering the bone lesion.

• Kniest Dysplasia

  a rare, autosomal dominant inherited bone growth disorder caused by mutations in the col2a1gene. it is characterized by short stature (dwarfism) and other skeletal abnormalities, round, flat face with bulging and wide-set eyes, myopia and retinal detachment that can lead to blindness.

• Osteopoikilosis

  a rare autosomal dominant inherited disorder characterized by the presence of small areas of increased density throughout the bones.

Q78.8 is grouped with Diagnostic Related Groups - MS-DRG Mapping

Diagnostic Related Groups (DRGs) are a classification system used to group together diagnosis codes for the purpose of reimbursement and healthcare management. DRGs are used to standardize the way hospitals and other providers are paid for inpatient services. In this system patients are grouped together based on their principal diagnosis in areas referred to as Major Diagnostic Categories (MDC). Once a patient is assigned a particular diagnostic category, providers receive a predetermined payment rate for the services rendered. This reimbursement rate is often fixed and is meant to cover the cost of care for that patient. Reimbursement is also affected by the relative weight of a diagnostic related group based on the severity of a patient's illness and the associated cost of care during hospitalization.

Diagnostic related groups encourage healthcare providers to focus on quality and efficiency in patient care while managing costs effectively. The diagnosis code is present in the following groups for version MS-DRG V41.0 applicable from 10/01/2023 through 09/30/2024.

The relative weight of a diagnostic related group determines the reimbursement rate based on the severity of a patient's illness and the associated cost of care during hospitalization.

Present on Admission (POA)

Q78.8 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

Convert Q78.8 to ICD-9-CM

• ICD-9-CM Code: 756.53 - Osteopoikilosis
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
• ICD-9-CM Code: 756.59 - Osteodystrophy NEC
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.