2026 ICD-10-CM Diagnosis Code G92.00Immune effector cell-associated neurotoxicity syndrome, grade unspecified

ICD-10-CM Codes›G00–G99›G89-G99›G92

ICD-10-CM G92.00
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

G92.00 is a billable ICD-10-CM diagnosis code for immune effector cell-associated neurotoxicity syndrome, grade unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as immune effector cell-associated neurotoxicity syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other nervous system disorders (neither hereditary nor degenerative).

Code Identity

ICD-10-CM Code
G92.00
Billable Status
Yes — Valid for Submission
Code Describes
Immune effector cell-associated neurotoxicity syndrome, grade unspecified
Short Description
Immune effor cell-associated neurotoxicity synd, grade unsp
Parent Code
G92.0
Immune effector cell-associated neurotoxicity syndrome

Code Classification

ChapterG00–G99Diseases of the nervous system
SectionG89-G99Other disorders of the nervous system
CategoryG92Toxic encephalopathy
This CodeG92.00Immune effector cell-associated neurotoxicity syndrome, grade unspecified

Code EditsBilling

Medicare Code Editor checks that affect claim validity for G92.00.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Immune effector cell-associated neurotoxicity syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • ICANS, grade unspecified

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Syndrome
      • immune effector cell-associated neurotoxicity (ICANS)
    • Syndrome
      • immune effector cell-associated neurotoxicity (ICANS)
        • grade
          • unspecified

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient No · outpatient No
CCSR NVS020
Other nervous system disorders (neither hereditary nor degenerative)
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement G92.00 replaces the following previously assigned code(s):

  • G92 - Toxic encephalopathy
FY 2022AddedAdded to the ICD-10-CM code setEffective October 1, 2021.
FY 2023–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About G92.00Overview

Is G92.00 (Immune effector cell-associated neurotoxicity syndrome) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report immune effector cell-associated neurotoxicity syndrome, grade unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can G92.00 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because immune effector cell-associated neurotoxicity syndrome, grade unspecified describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.