2027 ICD-10-CM Diagnosis Code E53.0Riboflavin deficiency
ICD-10-CM Codes›E00–E89›E50-E64›E53
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Not Chronic
E53.0 is a billable ICD-10-CM diagnosis code for riboflavin deficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 640 through 641. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 34 closely related codes. Coders also document this condition as anemia due to riboflavin deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anemia due to riboflavin deficiency
- Ariboflavinosis
- Gopalan's syndrome
- Inadequate intake of riboflavin
- Maternal riboflavin deficiency
- Non megaloblastic anemia associated with nutritional deficiency
- Vitamin B12 deficiency glossitis
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E53.0: its own notes plus those printed at E53, block E50-E64, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Ariboflavinosis
- Vitamin B2 deficiency
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- sequelae of vitamin B deficiency (E64.8)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E53.0, its category, or a range that includes it.
Excludes1 4
These codes carry an Excludes1 note naming E53.0: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 2
These codes carry an Excludes2 note naming E53.0: its condition is not part of those codes, and both may be reported when the patient has both.
- Block L00-L08 Infections of the skin and subcutaneous tissuePerlèche due to riboflavin deficiency (E53.0)
- D51 Vitamin B12 deficiency anemiadeficiency of other B group vitamins (E53-) names E53-, which includes this code
Code First 3
These codes say to code first a condition named in the note, and E53.0 is one of the conditions named.
Notes 1
These notes mention E53.0.
- E64 Sequelae of malnutrition and other nutritional deficienciesThis category is to be used to indicate conditions in categories E43, E44, E46, E50-E63 as the cause of sequelae, which are themselves classified elsewhere. The 'sequelae' include conditions specified as such; they also include the late effects of diseases classifiable to the above categories if the disease itself is no longer present names E50-E63, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Ariboflavinosis E53.0
Avitaminosis (multiple) See Also: Deficiency, vitamin; E56.9
riboflavin (vitamin B2) E53.0
B2 (riboflavin) E53.0
G E53.0
Riboflavin deficiency E53.0
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Riboflavin Deficiency
a dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (dorland, 27th ed)
Patient EducationClinical
B Vitamins
The B vitamins are:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E53.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E53.0Overview
What is the ICD-10 code for riboflavin deficiency?
The ICD-10-CM code for riboflavin deficiency is E53.0 (sometimes written as E530). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E53.0 (Deficiency of other B group vitamins) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report riboflavin deficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E53.0 group to?
When riboflavin deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 641, 640, with relative weights from 0.7864 to 1.3392 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E53.0 a CC or MCC?
CMS lists E53.0 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 34 closely related codes in its exclusion list.
Can E53.0 be reported with E64.8?
Not as a rule. The Excludes1 note at E53, which applies to E53.0, lists "sequelae of vitamin B deficiency (E64.8)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
