2026 ICD-10-CM Diagnosis Code E53.0Riboflavin deficiency

ICD-10-CM Codes›E00–E89›E50-E64›E53

ICD-10-CM E53.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E53.0 is a billable ICD-10-CM diagnosis code for riboflavin deficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. Coders also document this condition as anemia due to riboflavin deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.

Code Identity

ICD-10-CM Code
E53.0
Billable Status
Yes — Valid for Submission
Code Describes
Riboflavin deficiency
Short Description
Riboflavin deficiency
Same as the full description in the CMS dataset.
Parent Code
E53
Deficiency of other B group vitamins

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE50-E64Other nutritional deficiencies
CategoryE53Deficiency of other B group vitamins
This CodeE53.0Riboflavin deficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Anemia due to riboflavin deficiency
  • Ariboflavinosis
  • Gopalan's syndrome
  • Inadequate intake of riboflavin
  • Maternal riboflavin deficiency
  • Non megaloblastic anemia associated with nutritional deficiency
  • Vitamin B12 deficiency glossitis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Ariboflavinosis
  • Vitamin B2 deficiency

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Ariboflavinosis
    • Avitaminosis(multiple)
      • B2
    • Avitaminosis(multiple)
      • G
    • Cheilosis(angular)
      • due to
        • vitamin B2 (riboflavin) deficiency
    • Deficiency, deficient
      • riboflavin (vitamin B2)
    • Deficiency, deficient
      • vitamin (multiple) NOS
        • B2 (riboflavin)
    • Deficiency, deficient
      • vitamin (multiple) NOS
        • G
    • Gopalan's syndrome(burning feet)
    • Perlèche NEC
      • due to
        • riboflavin deficiency
    • Perlèche NEC
      • due to
        • vitamin B2 (riboflavin) deficiency
    • Riboflavin deficiency
    • Stomatitis(denture) (ulcerative)
      • angular
        • due to dietary or vitamin deficiency
    • Stomatitis(denture) (ulcerative)
      • due to
        • dietary deficiency
    • Stomatitis(denture) (ulcerative)
      • due to
        • vitamin deficiency
          • B2 (riboflavin)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END007
Nutritional deficiencies
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Riboflavin Deficiency

    a dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (dorland, 27th ed)

Patient EducationClinical

B Vitamins

The B vitamins are:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E53.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
266.0 Ariboflavinosis
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E53.0Overview

Is E53.0 (Deficiency of other B group vitamins) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report riboflavin deficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E53.0 group to?

When riboflavin deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E53.0?

Under the General Equivalence Mappings, riboflavin deficiency converts to ICD-9-CM 266.0 (ariboflavinosis). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.