2027 ICD-10-CM Diagnosis Code E16.0Drug-induced hypoglycemia without coma
ICD-10-CM Codes›E00–E89›E15-E16›E16
- Billable — Valid for Submission
- Not Chronic
E16.0 is a billable ICD-10-CM diagnosis code for drug-induced hypoglycemia without coma. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. Coders also document this condition as alcohol-induced hypoglycemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Alcohol-induced hypoglycemia
- Autonomic neuropathy due to medication induced hypoglycemia
- Drug-induced hyperinsulinemia
- Drug-induced hypoglycemia
- Drug-induced hypoglycemia without coma
- Iatrogenic hypoglycemia
- Neuropathy associated with hypoglycemia
- Non-diabetic hypoglycemia
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E16.0: its own notes plus those printed at Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- diabetes with hypoglycemia without coma (E09.649)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E16.0, its category, or a range that includes it.
Code First 1
These codes say to code first a condition named in the note, and E16.0 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E16.0.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Hypoglycemia (spontaneous) E16.2
drug-induced E16.0
due to insulin E16.0
iatrogenic E16.0
Reaction See Also: Disorder;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Hypoglycemia
Blood glucose, or blood sugar, is the main sugar found in your blood. It is your body's primary source of energy. It comes from the food you eat. Your body breaks down most of that food into glucose and releases it into your bloodstream. When your blood glucose goes up, it signals your pancreas to release insulin.
The full article covers:
- What is blood glucose?
- What is hypoglycemia?
- What causes hypoglycemia?
- What are the symptoms of hypoglycemia?
- How is hypoglycemia diagnosed?
- What are the treatments for hypoglycemia?
- Can hypoglycemia be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E16.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E16.0Overview
What is the ICD-10 code for drug-induced hypoglycemia without coma?
The ICD-10-CM code for drug-induced hypoglycemia without coma is E16.0 (sometimes written as E160). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E16.0 (Other disorders of pancreatic internal secretion) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced hypoglycemia without coma on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E16.0 group to?
When drug-induced hypoglycemia without coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E16.0 be reported with E09.649?
Not as a rule. The Excludes1 note on E16.0 lists "diabetes with hypoglycemia without coma (E09.649)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E16.0 need an additional code?
When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5); code for hypoglycemia level, if applicable (E16.A-). The additional code is reported after E16.0.
