2026 ICD-10-CM Diagnosis Code E16.0Drug-induced hypoglycemia without coma

ICD-10-CM Codes›E00–E89›E15-E16›E16

ICD-10-CM E16.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E16.0 is a billable ICD-10-CM diagnosis code for drug-induced hypoglycemia without coma. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as alcohol-induced hypoglycemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E16.0
Billable Status
Yes — Valid for Submission
Code Describes
Drug-induced hypoglycemia without coma
Short Description
Drug-induced hypoglycemia without coma
Same as the full description in the CMS dataset.
Parent Code
E16
Other disorders of pancreatic internal secretion

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE15-E16Other disorders of glucose regulation and pancreatic internal secretion
CategoryE16Other disorders of pancreatic internal secretion
This CodeE16.0Drug-induced hypoglycemia without coma

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alcohol-induced hypoglycemia
  • Autonomic neuropathy due to medication induced hypoglycemia
  • Drug-induced hyperinsulinemia
  • Drug-induced hypoglycemia
  • Drug-induced hypoglycemia without coma
  • Iatrogenic hypoglycemia
  • Neuropathy associated with hypoglycemia
  • Non-diabetic hypoglycemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Type 1 Excludes

  • diabetes with hypoglycemia without coma E09.649

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hypoglycemia(spontaneous)
      • drug-induced
    • Hypoglycemia(spontaneous)
      • due to insulin
    • Hypoglycemia(spontaneous)
      • iatrogenic
    • Reaction
      • hypoglycemic, due to insulin

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Hypoglycemia

Blood glucose, or blood sugar, is the main sugar found in your blood. It is your body's primary source of energy. It comes from the food you eat. Your body breaks down most of that food into glucose and releases it into your bloodstream. When your blood glucose goes up, it signals your pancreas to release insulin.

The full article covers:

  • What is blood glucose?
  • What is hypoglycemia?
  • What causes hypoglycemia?
  • What are the symptoms of hypoglycemia?
  • How is hypoglycemia diagnosed?
  • What are the treatments for hypoglycemia?
  • Can hypoglycemia be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E16.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
251.1 Oth spcf hypoglycemia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E16.0Overview

Is E16.0 (Other disorders of pancreatic internal secretion) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced hypoglycemia without coma on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E16.0 group to?

When drug-induced hypoglycemia without coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E16.0?

Under the General Equivalence Mappings, drug-induced hypoglycemia without coma converts to ICD-9-CM 251.1 (oth spcf hypoglycemia). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.