Other disorders of pancreatic internal secretion (E16) ICD-10-CM
The E16 code range covers other disorders of pancreatic internal secretion with 12 ICD-10-CM diagnosis codes. 10 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the E16 Range 12 codes · 10 billable
- E16 Other disorders of pancreatic internal secretionNon-billable
- E16.0 Drug-induced hypoglycemia without coma
- E16.1 Other hypoglycemia
- E16.2 Hypoglycemia, unspecified
- E16.3 Increased secretion of glucagon
- E16.4 Increased secretion of gastrin
- E16.8 Other specified disorders of pancreatic internal secretion
- E16.9 Disorder of pancreatic internal secretion, unspecified
- E16.A Hypoglycemia levelNon-billable
- E16.A1 Hypoglycemia level 1
- E16.A2 Hypoglycemia level 2
- E16.A3 Hypoglycemia level 3
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E16 range.
Hyperinsulinism
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
Hypoglycemia
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Zollinger-Ellison Syndrome
A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.
About the E16 Code Range
These disorders involve hypoglycemia, or low blood sugar, and changes in hormone release from the pancreas.
Hypoglycemia is separated into drug-induced cases without coma (E16.0), other forms (E16.1), and unspecified cases (E16.2). E16.A separates hypoglycemia by level: level 1, level 2, or level 3.
Other subdivisions identify increased release of glucagon (E16.3) or gastrin (E16.4). They also distinguish other specified pancreatic hormone disorders (E16.8) from unspecified ones (E16.9).
Questions About This Page
How many billable codes are in the E16 range?
Of the 12 codes in this range, 10 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the E16 range classify?
The range classifies other disorders of pancreatic internal secretion. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
