2027 ICD-10-CM Diagnosis Code E08.10Diabetes mellitus due to underlying condition with ketoacidosis without coma
ICD-10-CM Codes›E00–E89›E08-E13›E08
- Billable — Valid for Submission
- MCC — Major Complication or Comorbidity
- Risk Adjusts — HCC 36
- Chronic Condition
E08.10 is a billable ICD-10-CM diagnosis code for diabetes mellitus due to underlying condition with ketoacidosis without coma. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 8, 10, 19, 637 through 639. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 352 closely related codes. The code is a manifestation code that cannot be reported as the principal diagnosis. Coders also document this condition as diabetic ketoacidosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diabetes mellitus with complication; and Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type.
For Medicare Advantage risk adjustment, E08.10 maps to CMS-HCC Category 36 (Diabetes with Severe Acute Complications) under the V28 model, adding a risk factor of about 0.166 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for E08.10.
Medicare Risk Adjustment (HCC)Billing
E08.10 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Diabetic ketoacidosis
- Disorder due to malnutrition related diabetes mellitus
- Ketoacidosis due to secondary diabetes mellitus
- Malnutrition-related diabetes mellitus with ketoacidosis
Coding GuidelinesGuidance
The diabetes mellitus codes are combination codes that include the type of diabetes mellitus, the body system affected, and the complications affecting that body system. As many codes within a particular category as are necessary to describe all of the complications of the disease may be used. They should be sequenced based on the reason for a particular encounter. Assign as many codes from categories E08 - E13 as needed to identify all of the associated conditions that the patient has.
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E08.10: its own notes plus those printed at E08 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- drug or chemical induced diabetes mellitus (E09.-)
- gestational diabetes (O24.4-)
- neonatal diabetes mellitus (P70.2)
- postpancreatectomy diabetes mellitus (E13.-)
- postprocedural diabetes mellitus (E13.-)
- secondary diabetes mellitus NEC (E13.-)
- type 1 diabetes mellitus (E10.-)
- type 2 diabetes mellitus (E11.-)
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E08.10, its category, or a range that includes it.
Excludes1 4
These codes carry an Excludes1 note naming E08.10: they are not reported together with it, unless the two conditions are unrelated.
- E09 Drug or chemical induced diabetes mellitusdiabetes mellitus due to underlying condition (E08.-) names E08.-, which includes this code
- E10 Type 1 diabetes mellitusdiabetes mellitus due to underlying condition (E08.-) names E08.-, which includes this code
- E11 Type 2 diabetes mellitusdiabetes mellitus due to underlying condition (E08.-) names E08.-, which includes this code
- E13 Other specified diabetes mellitusdiabetes mellitus due to underlying condition (E08.-) names E08.-, which includes this code
Excludes2 2
These codes carry an Excludes2 note naming E08.10: its condition is not part of those codes, and both may be reported when the patient has both.
- E87.0 Hyperosmolality and hypernatremiadiabetes with hyperosmolarity (E08, E09, E11, E13 with final characters .00 or .01) names E08, which includes this code
- R11.15 Cyclical vomiting syndrome unrelated to migrainediabetes mellitus due to underlying condition (E08.-) names E08.-, which includes this code
Use Additional Code 2
These codes say to use an additional code from the note, and E08.10 is one of the codes named.
- O24.8 Other pre-existing diabetes mellitus in pregnancy, childbirth, and the puerperiumfrom categories E08, E09 and E13 to further identify any manifestation names E08, which includes this code
- O24.9 Unspecified diabetes mellitus in pregnancy, childbirth and the puerperiumfrom categories E08, E09 and E13 to further identify any manifestation names E08, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Diabetes
Diabetes, also known as diabetes mellitus, is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose is your body's main source of energy. Your body can make glucose, but it also comes from the food you eat. Insulin is a hormone made by your pancreas.
The full article covers:
- What is diabetes?
- What are the types of diabetes?
- What causes diabetes?
- Who is more likely to develop diabetes?
- What are the symptoms of diabetes?
- How is diabetes diagnosed?
- What are the treatments for diabetes?
- Can diabetes be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E08.10 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E08.10Overview
Is E08.10 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report diabetes mellitus due to underlying condition with ketoacidosis without coma on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E08.10 group to?
On inpatient claims, diabetes mellitus due to underlying condition with ketoacidosis without coma maps to MS-DRG 638, 639, 8, 10, 637, 19, with relative weights from 0.6375 to 7.5461 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E08.10 a CC or MCC?
CMS lists E08.10 as an MCC (major complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 352 closely related codes in its exclusion list.
Can E08.10 be a principal diagnosis?
No. This is a manifestation code: diabetes mellitus due to underlying condition with ketoacidosis without coma describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.
Can E08.10 be reported with a code from E09?
Not as a rule. The Excludes1 note at E08, which applies to E08.10, lists "drug or chemical induced diabetes mellitus (E09.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is E08.10?
E08.10 (diabetes mellitus due to underlying condition with ketoacidosis without coma) maps to CMS-HCC Category 36 (Diabetes with Severe Acute Complications), commonly written as HCC 36, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 17 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 30.
Does E08.10 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, E08.10 adds a risk adjustment factor of about 0.166 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.166 to 0.280 depending on the payment segment). A more severe related category (HCC 35) supersedes it when both are reported. See the full factor table on the HCC 36 category page.
