Diabetes mellitus due to underlying condition (E08) ICD-10-CM
The E08 code range covers diabetes mellitus due to underlying condition with 116 ICD-10-CM diagnosis codes. 86 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
- the underlying condition, such as:
- congenital rubella P35.0
- Cushing's syndrome E24
- cystic fibrosis E84
- malignant neoplasm C00 C96
- malnutrition E40 E46
- pancreatitis and other diseases of the pancreas K85 K86
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
- code to identify control using:
- injectable non-insulin antidiabetic drugs Z79.85
- insulin Z79.4
- oral antidiabetic drugs Z79.84
- oral hypoglycemic drugs Z79.84
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the E08 Range 116 codes · 86 billable
- E08 Diabetes mellitus due to underlying conditionNon-billable
- E08.0 Diabetes mellitus due to underlying condition with hyperosmolarityNon-billable
- E08.00 Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
- E08.01 Diabetes mellitus due to underlying condition with hyperosmolarity with coma
- E08.1 Diabetes mellitus due to underlying condition with ketoacidosisNon-billable
- E08.10 Diabetes mellitus due to underlying condition with ketoacidosis without coma
- E08.11 Diabetes mellitus due to underlying condition with ketoacidosis with coma
- E08.2 Diabetes mellitus due to underlying condition with kidney complicationsNon-billable
- E08.21 Diabetes mellitus due to underlying condition with diabetic nephropathy
- E08.22 Diabetes mellitus due to underlying condition with diabetic chronic kidney disease
- E08.29 Diabetes mellitus due to underlying condition with other diabetic kidney complication
- E08.3 Diabetes mellitus due to underlying condition with ophthalmic complicationsNon-billable
- E08.31 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathyNon-billable
- E08.311 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy with macular edema
- E08.319 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy without macular edema
- E08.32 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathyNon-billable
- E08.321 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edemaNon-billable
- E08.3211 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, right eye
- E08.3212 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, left eye
- E08.3213 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, bilateral
- E08.3219 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, unspecified eye
- E08.329 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edemaNon-billable
- E08.3291 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, right eye
- E08.3292 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, left eye
- E08.3293 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, bilateral
- E08.3299 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, unspecified eye
- E08.33 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathyNon-billable
- E08.331 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edemaNon-billable
- E08.3311 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, right eye
- E08.3312 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, left eye
- E08.3313 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, bilateral
- E08.3319 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, unspecified eye
- E08.339 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edemaNon-billable
- E08.3391 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, right eye
- E08.3392 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, left eye
- E08.3393 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, bilateral
- E08.3399 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, unspecified eye
- E08.34 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathyNon-billable
- E08.341 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edemaNon-billable
- E08.3411 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, right eye
- E08.3412 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, left eye
- E08.3413 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, bilateral
- E08.3419 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, unspecified eye
- E08.349 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edemaNon-billable
- E08.3491 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edema, right eye
- E08.3492 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edema, left eye
- E08.3493 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edema, bilateral
- E08.3499 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edema, unspecified eye
- E08.35 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathyNon-billable
- E08.351 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edemaNon-billable
- E08.3511 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema, right eye
- E08.3512 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema, left eye
- E08.3513 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema, bilateral
- E08.3519 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema, unspecified eye
- E08.352 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment involving the maculaNon-billable
- E08.3521 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment involving the macula, right eye
- E08.3522 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment involving the macula, left eye
- E08.3523 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment involving the macula, bilateral
- E08.3529 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment involving the macula, unspecified eye
- E08.353 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment not involving the maculaNon-billable
- E08.3531 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment not involving the macula, right eye
- E08.3532 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment not involving the macula, left eye
- E08.3533 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment not involving the macula, bilateral
- E08.3539 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with traction retinal detachment not involving the macula, unspecified eye
- E08.354 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachmentNon-billable
- E08.3541 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment, right eye
- E08.3542 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment, left eye
- E08.3543 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment, bilateral
- E08.3549 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment, unspecified eye
- E08.355 Diabetes mellitus due to underlying condition with stable proliferative diabetic retinopathyNon-billable
- E08.3551 Diabetes mellitus due to underlying condition with stable proliferative diabetic retinopathy, right eye
- E08.3552 Diabetes mellitus due to underlying condition with stable proliferative diabetic retinopathy, left eye
- E08.3553 Diabetes mellitus due to underlying condition with stable proliferative diabetic retinopathy, bilateral
- E08.3559 Diabetes mellitus due to underlying condition with stable proliferative diabetic retinopathy, unspecified eye
- E08.359 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edemaNon-billable
- E08.3591 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, right eye
- E08.3592 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, left eye
- E08.3593 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, bilateral
- E08.3599 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, unspecified eye
- E08.36 Diabetes mellitus due to underlying condition with diabetic cataract
- E08.37 Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatmentNon-billable
- E08.37X1 Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, right eye
- E08.37X2 Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, left eye
- E08.37X3 Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, bilateral
- E08.37X9 Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, unspecified eye
- E08.39 Diabetes mellitus due to underlying condition with other diabetic ophthalmic complication
- E08.4 Diabetes mellitus due to underlying condition with neurological complicationsNon-billable
- E08.40 Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified
- E08.41 Diabetes mellitus due to underlying condition with diabetic mononeuropathy
- E08.42 Diabetes mellitus due to underlying condition with diabetic polyneuropathy
- E08.43 Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy
- E08.44 Diabetes mellitus due to underlying condition with diabetic amyotrophy
- E08.49 Diabetes mellitus due to underlying condition with other diabetic neurological complication
- E08.5 Diabetes mellitus due to underlying condition with circulatory complicationsNon-billable
- E08.51 Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy without gangrene
- E08.52 Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene
- E08.59 Diabetes mellitus due to underlying condition with other circulatory complications
- E08.6 Diabetes mellitus due to underlying condition with other specified complicationsNon-billable
- E08.61 Diabetes mellitus due to underlying condition with diabetic arthropathyNon-billable
- E08.610 Diabetes mellitus due to underlying condition with diabetic neuropathic arthropathy
- E08.618 Diabetes mellitus due to underlying condition with other diabetic arthropathy
- E08.62 Diabetes mellitus due to underlying condition with skin complicationsNon-billable
- E08.620 Diabetes mellitus due to underlying condition with diabetic dermatitis
- E08.621 Diabetes mellitus due to underlying condition with foot ulcer
- E08.622 Diabetes mellitus due to underlying condition with other skin ulcer
- E08.628 Diabetes mellitus due to underlying condition with other skin complications
- E08.63 Diabetes mellitus due to underlying condition with oral complicationsNon-billable
- E08.630 Diabetes mellitus due to underlying condition with periodontal disease
- E08.638 Diabetes mellitus due to underlying condition with other oral complications
- E08.64 Diabetes mellitus due to underlying condition with hypoglycemiaNon-billable
- E08.641 Diabetes mellitus due to underlying condition with hypoglycemia with coma
- E08.649 Diabetes mellitus due to underlying condition with hypoglycemia without coma
- E08.65 Diabetes mellitus due to underlying condition with hyperglycemia
- E08.69 Diabetes mellitus due to underlying condition with other specified complication
- E08.8 Diabetes mellitus due to underlying condition with unspecified complications
- E08.9 Diabetes mellitus due to underlying condition without complications
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E08 range.
Diabetic Ketoacidosis
A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.
About the E08 Code Range
ICD-10 code E08 covers diabetes mellitus due to an underlying condition, differentiating it from other types like Type 1 or Type 2 diabetes. These codes capture diabetes caused by specific health issues such as pancreatic injury or malnutrition. Variations in the codes specify complications like hyperosmolarity, ketoacidosis, kidney or eye problems, neurological issues, circulatory complications, and more.
This section of ICD-10 codes helps medical coders accurately document cases when diabetes arises secondary to another disease or disorder. For example, conditions labeled as "malnutrition-related diabetes mellitus" or "diabetes mellitus associated with pancreatic disease" fall under E08. Specific complications are further detailed: codes with ketoacidosis (also known as diabetic ketoacidosis) range from E08.10 to E08.11, while codes like E08.21 specify diabetic nephropathy. Eye-related complications, including diabetic retinopathy in various stages and with or without macular edema, have dedicated codes (E08.31 to E08.39). Codes also cover neuropathy types, circulatory complications such as diabetic peripheral angiopathy, and skin complications including foot ulcers. This detailed system ensures precise coding of diabetes mellitus due to underlying causes, aiding in targeted treatment and data tracking.
Questions About This Page
How many billable codes are in the E08 range?
Of the 116 codes in this range, 86 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E08 range classify?
The range classifies diabetes mellitus due to underlying condition. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
