2026 ICD-10-CM Diagnosis Code D89.89Other specified disorders involving the immune mechanism, not elsewhere classified
ICD-10-CM Codes›D50–D89›D80-D89›D89
- Billable — Valid for Submission
- Chronic Condition
D89.89 is a billable ICD-10-CM diagnosis code for other specified disorders involving the immune mechanism, not elsewhere classified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anti-human leukocyte antigen hyperimmunization
- Autoimmune disorder of bilateral inner ears
- Autoimmune disorder of inner ear
- Autoimmune disorder of left inner ear
- Autoimmune disorder of right inner ear
- Autoimmune enteropathy
- Autoimmune enteropathy and endocrinopathy with susceptibility to chronic infection syndrome
- Autoimmune reaction following infectious disease
- Autoimmune reaction mediated by antibody to tissue element with complement
- Autoimmune reaction mediated by antibody to tissue element without complement
- Autoimmune reaction mediated by B cells
- Autoimmune reaction mediated by cell-mediated immunity
- Autoimmune reaction mediated by immune complex
- Autoimmune reaction mediated by T cells
- Autoimmune reaction, specific organ or cell type
- Autoimmune state
- Autoleukocyte sensitivity
- Autologous state
- Autosensitivity
- BCG granuloma
- Diffuse antibody band pattern
- Disorder of immunoglobulin
- Familial immunoglobulin hypercatabolism
- Hyperimmune state
- Immune dysregulation, inflammatory bowel disease, arthritis, recurrent infection syndrome
- Immunoglobulin hypercatabolism
- Immunologic patching
- Impaired phagocytosis
- Infection caused by Mycobacterium bovis
- Inflammatory disorder of immune system
- Isoimmunization
- Labyrinthitis of bilateral inner ears
- Labyrinthitis of left inner ear
- Labyrinthitis of right inner ear
- Low immunologic affinity
- Nakajo-Nishimura syndrome
- Non-pyogenic bacterial infection of skin
- Pernicious anemia
- Pernicious anemia due to autoimmune disorder
- Primary immunoglobulin catabolism abnormality
- Restricted antibody band pattern
- Reticuloendothelial blockade
- Tuftsin deficiency
- X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Type 1 Excludes
- human immunodeficiency virus disease B20
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Disorder (of) - See Also: Disease;
- autoimmune - D89.89
- immune mechanism (immunity) - D89.9
- specified type NEC - D89.89
- Syndrome - See Also: Disease;
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Disorder(of)
- autoimmune
- Disorder(of)
- immune mechanism (immunity)
- specified type NEC
- PANDAS(pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome)
- Syndrome
- pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D89.89 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D89.89Overview
Is D89.89 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders involving the immune mechanism, not elsewhere classified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D89.89 group to?
When other specified disorders involving the immune mechanism, not elsewhere classified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D89.89?
Under the General Equivalence Mappings, other specified disorders involving the immune mechanism, not elsewhere classified converts to ICD-9-CM 279.8 (immune mechanism dis NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
