2026 ICD-10-CM Diagnosis Code D82.8Immunodeficiency associated with other specified major defects

ICD-10-CM Codes›D50–D89›D80-D89›D82

ICD-10-CM D82.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D82.8 is a billable ICD-10-CM diagnosis code for immunodeficiency associated with other specified major defects. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. Coders also document this condition as hereditary angioedema. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D82.8
Billable Status
Yes — Valid for Submission
Code Describes
Immunodeficiency associated with other specified major defects
Short Description
Immunodeficiency associated with oth major defects
Parent Code
D82
Immunodeficiency associated with other major defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD82Immunodeficiency associated with other major defects
This CodeD82.8Immunodeficiency associated with other specified major defects

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hereditary angioedema
  • Hereditary angioedema with normal C1 esterase inhibitor activity
  • Immunodeficiency associated with 18p syndrome
  • Primary immunodeficiency syndrome due to p14 deficiency
  • X-linked immunoneurologic disorder

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Immunodeficiency
      • with
        • major defect
          • specified type NEC
    • Immunodeficiency
      • with
        • partial albinism

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hereditary Angioedema

    autosomal dominant inherited disorder characterized by abnormalities of c1 inhibitor. patients present with swelling of the skin, subcutaneous tissues, and mucosa sites.

  • Hereditary Angioedema Types I and II

    autosomal dominant inherited disorders characterized by abnormalities of c1 inhibitor. patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. in type i hereditary angioedema, the plasma levels of c1 inhibitor are decreased. in type ii hereditary angioedema, the c1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D82.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.8 Immune mechanism dis NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D82.8Overview

Is D82.8 (Immunodeficiency associated with other major defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report immunodeficiency associated with other specified major defects on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D82.8 group to?

When immunodeficiency associated with other specified major defects is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D82.8?

Under the General Equivalence Mappings, immunodeficiency associated with other specified major defects converts to ICD-9-CM 279.8 (immune mechanism dis NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.