Valid for Submission
D82.3 is a billable diagnosis code used to specify a medical diagnosis of immunodeficiency following hereditary defective response to epstein-barr virus. The code D82.3 is valid during the fiscal year 2021 from October 01, 2020 through September 30, 2021 for the submission of HIPAA-covered transactions.
The ICD-10-CM code D82.3 might also be used to specify conditions or terms like immunodeficiency following hereditary defective response to epstein-barr virus, immunodeficiency with major anomalies, x-linked immunodeficiency with magnesium defect, epstein-barr virus infection and neoplasia or x-linked lymphoproliferative syndrome.
Tabular List of Diseases and Injuries
The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D82.3:
Inclusion TermsInclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
- X-linked lymphoproliferative disease
Index to Diseases and Injuries
The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D82.3 are found in the index:
- - Immunodeficiency - D84.9
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Immunodeficiency following hereditary defective response to Epstein-Barr virus
- Immunodeficiency with major anomalies
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- X-linked lymphoproliferative syndrome
Diagnostic Related Groups - MS-DRG Mapping
Convert D82.3 to ICD-9 Code
The General Equivalency Mapping (GEM) crosswalk indicates an approximate mapping between the ICD-10 code D82.3 its ICD-9 equivalent. The approximate mapping means there is not an exact match between the ICD-10 code and the ICD-9 code and the mapped code is not a precise representation of the original code.
Information for Patients
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.
If your immune system cannot do its job, the results can be serious. Disorders of the immune system include
- Allergy and asthma - immune responses to substances that are usually not harmful
- Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
- Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake
NIH: National Institute of Allergy and Infectious Diseases
- Agammaglobulinemia (Medical Encyclopedia)
- Aging changes in immunity (Medical Encyclopedia)
- Chronic granulomatous disease (Medical Encyclopedia)
- Graft-versus-host disease (Medical Encyclopedia)
- Histiocytosis (Medical Encyclopedia)
- Hyperimmunoglobulin E syndrome (Medical Encyclopedia)
- Immune response (Medical Encyclopedia)
- Immunodeficiency disorders (Medical Encyclopedia)
- Selective deficiency of IgA (Medical Encyclopedia)
[Learn More in MedlinePlus]
X-linked lymphoproliferative disease X-linked lymphoproliferative disease (XLP) is a disorder of the immune system and blood-forming cells that is found almost exclusively in males. More than half of individuals with this disorder experience an exaggerated immune response to the Epstein-Barr virus (EBV). EBV is a very common virus that eventually infects most humans. In some people it causes infectious mononucleosis (commonly known as "mono"). Normally, after initial infection, EBV remains in certain immune system cells (lymphocytes) called B cells. However, the virus is generally inactive (latent) because it is controlled by other lymphocytes called T cells that specifically target EBV-infected B cells.People with XLP may respond to EBV infection by producing abnormally large numbers of T cells, B cells, and other lymphocytes called macrophages. This proliferation of immune cells often causes a life-threatening reaction called hemophagocytic lymphohistiocytosis. Hemophagocytic lymphohistiocytosis causes fever, destroys blood-producing cells in the bone marrow, and damages the liver. The spleen, heart, kidneys, and other organs and tissues may also be affected. In some individuals with XLP, hemophagocytic lymphohistiocytosis or related symptoms may occur without EBV infection.About one-third of people with XLP experience dysgammaglobulinemia, which means they have abnormal levels of some types of antibodies. Antibodies (also known as immunoglobulins) are proteins that attach to specific foreign particles and germs, marking them for destruction. Individuals with dysgammaglobulinemia are prone to recurrent infections.Cancers of immune system cells (lymphomas) occur in about one-third of people with XLP.Without treatment, most people with XLP survive only into childhood. Death usually results from hemophagocytic lymphohistiocytosis.XLP can be divided into two types based on its genetic cause and pattern of signs and symptoms: XLP1 (also known as classic XLP) and XLP2. People with XLP2 have not been known to develop lymphoma, are more likely to develop hemophagocytic lymphohistiocytosis without EBV infection, usually have an enlarged spleen (splenomegaly), and may also have inflammation of the large intestine (colitis). Some researchers believe that these individuals should actually be considered to have a similar but separate disorder rather than a type of XLP.
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