2027 ICD-10-CM Diagnosis Code D49.9Neoplasm of unspecified behavior of unspecified site
ICD-10-CM Codes›C00–D49›D49›D49
- Billable — Valid for Submission
- Not Chronic
ICD-10-CM D49.9
D49.9 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of unspecified site. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 826 through 830, 843 through 845. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
ICD-10-CM Code
D49.9
Billable Status
Yes — Valid for Submission
Code Describes
Neoplasm of unspecified behavior of unspecified site
Short Description
Neoplasm of unspecified behavior of unspecified site
Same as the full description in the CMS dataset.
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired ichthyosis
- Acquired paraneoplastic ichthyosis
- Acute febrile neutrophilic dermatosis
- Acute febrile neutrophilic dermatosis due to neoplastic disease
- Ampulla of Vater surgical margin, involved by tumor
- Ampulla of Vater, distal pancreatic surgical margin, involved by tumor
- Ampulla of Vater, posterior retroperitoneal pancreatic surface surgical margin, involved by tumor
- Anal, deep radial surgical margin not involved by tumor
- Anal, distal surgical margin not involved by tumor
- Anal, proximal surgical margin not involved by tumor
- Anaplasia absent
- Annular tumor configuration
- Anterior cord syndrome due to neoplasm
- Anterior margin of tumor located anterior to equator of globe
- Brachial plexus neuropathy due to neoplasm
- Brainstem encephalitis
- Brown-Séquard syndrome due to neoplastic disease
- Carcinoma-associated retinopathy
- Central cord syndrome due to neoplasm
- Cervical margins indeterminate for tumor involvement
- Chorea due to paraneoplastic syndrome
- Chronic tubulointerstitial nephritis due to neoplastic disease
- Circumscribed tumor border
- Comedo tumor pattern
- Complete obstructing tumor
- Coronary artery occlusion due to neoplastic disease
- Cribriform tumor pattern
- Cystic tumor configuration
- Cystic, entirely encapsulated tumor
- Cystic, partially encapsulated tumor
- Deep radial periureteral soft tissue surgical margin, involved by tumor
- Deep surgical margin involvement by tumor present
- Dementia due to paraneoplastic encephalitis
- Dermatomyositis with malignant disease
- Diffuse anaplasia
- Diffuse tumor configuration
- Disorder of lumbosacral plexus due to neoplastic disease
- Disorder of optic chiasm due to non-pituitary neoplasm
- Distal pancreatic surgical margin, involved by tumor
- Distal ureteral surgical margin, involved by tumor
- Distance of tumor from anal verge unknown
- Ectopic aldosterone secretion
- Ectopic aldosterone-producing neoplasm
- Endophytic tumor configuration
- Esophageal surgical margin, involved by tumor
- Esophagus, distal surgical margin, involved by tumor
- Esophagus, proximal surgical margin, involved by tumor
- Esophagus, radial surgical margin, involved by tumor
- Estrogen receptor positive neoplasm
- Excavated lesion of tumor
- Exophytic tumor configuration
- Expansile tumor configuration
- Extent of tumor involvement not specified
- Extrascleral tumor extension present
- Familial neoplastic disease
- Feminization
- Feminization due to neoplasm
- Flat tumor
- Flat tumor lesion
- Focal anaplasia
- Frond-like/villous tumor
- Fungating tumor
- Gerota's fascial surgical margin, involved by tumor
- Glomerular disease due to neoplastic disease
- Heart surgical margin, involved by tumor
- Hemolytic anemia due to nonlymphoid neoplasm
- Hemorrhagic tumor
- Hormone receptor negative neoplasm
- Hormone receptor positive neoplasm
- Hypercortisolism due to nonpituitary neoplasm
- Hypermelanosis due to ACTH/MSH-secreting tumor
- Hypermelanosis due to neoplasia
- Hypertrophic osteoarthropathy
- Hypoglycemia due to neoplasm
- Immunodeficiency secondary to neoplasm
- Infiltrative tumor configuration, macroscopic
- Intended postoperative presence of residual neoplasm following excision of neoplasm
- Intraductal tumor configuration
- Intraepithelial neoplasia due to human papillomavirus
- Intratumoral/peritumoral lymphocytic response absent
- Intratumoral/peritumoral lymphocytic response marked
- Intratumoral/peritumoral lymphocytic response mild to moderate
- Involvement of tumor by anaplasia indeterminate
- Juvenile polymyositis
- Juvenile polymyositis due to paraneoplastic syndrome
- Kidney, ureteral surgical margin, involved by tumor
- Large intestine surgical margin, involved by tumor
- Large intestine, deep radial surgical margin not involved by tumor
- Large intestine, deep radial surgical margin, involved by tumor
- Large intestine, distal surgical margin not involved by tumor
- Large intestine, distal surgical margin, involved by tumor
- Large intestine, proximal surgical margin not involved by tumor
- Large intestine, proximal surgical margin, involved by tumor
- Large tumor
- Left parametrial surgical margin, involved by tumor
- Left ventricular outflow tract obstruction due to neoplasm
- Limbic encephalitis
- Localized tumor configuration
- Lung surgical margin, involved by tumor
- Lung, attached tissue surgical margin, involved by tumor
- Lung, bronchial surgical margin, involved by tumor
- Lung, parenchymal surgical margin, involved by tumor
- Lung, vascular surgical margin, involved by tumor
- Malignant neoplasm detection during interval between recommended screening examinations
- Margin involvement indeterminate
- Marked peritumoral lymphocytic response
- Masquerade syndrome
- Mass of cervical vertebra
- Mass of lumbar vertebra
- Mass of thoracic vertebra
- Melanocytic neoplasm
- Microcalcifications in tumor and non-neoplastic tissue present
- Microcalcifications in tumor present
- Micropapillary tumor pattern
- Microvascular patterns present in tumor
- Mild to moderate peritumoral lymphocytic response
- Minimal change disease
- Minimal change disease due to neoplastic disorder
- Mismatch repair deficient neoplasm by immunohistochemistry
- Mismatch repair proficient neoplasm by immunohistochemistry
- Mixed endophytic and exophytic tumor configuration
- Motor neuron disease due to neoplastic disease
- Multifocal tumor
- Multiple cranial nerve palsies in neoplastic disease
- Myelopathy due to malignant neoplastic disease
- Myelopathy due to neoplastic disease
- Myopathy due to paraneoplastic syndrome
- Necrotic tumor
- Necrotizing cutaneous vasculitis
- Neoplasm and/or hamartoma
- Neoplasm following transplantation of bone marrow
- Neoplasm following transplantation of liver
- Neoplasm of bone of sacrum
- Neoplasm of cervical vertebra
- Neoplasm of lumbar vertebra
- Neoplasm of thoracic vertebra
- Neoplastic complication of procedure
- Neoplastic disease
- Neoplastic masquerade syndrome
- Neoplastic sequelae of disorders
- Nerve root and plexus compressions in neoplastic disease
- No additional pathologic finding in tumor specimen
- No direct extension of malignant neoplasm identified
- No peritumoral lymphocytic response
- No regional lymph node metastasis
- Non-diabetic hypoglycemia
- Non-viable tumor present in specimen
- Obstruction of aortic valve due to neoplasm
- Obstruction of inferior vena cava
- Obstruction of mitral valve due to neoplasm
- Obstruction of pulmonary valve due to neoplasm
- Obstruction of superior vena cava
- Obstruction of superior vena cava due to neoplasm
- Obstruction of tricuspid valve due to neoplasm
- Occlusion of inferior vena cava
- Occlusion of inferior vena cava due to neoplasm
- Occlusion of superior vena cava
- Occlusion of superior vena cava due to neoplasm
- Opsoclonus-myoclonus syndrome
- Osteitis deformans in neoplastic disease
- Ovarian surgical margin, involved by tumor
- Pancreatic surgical margin, involved by tumor
- Papillary tumor configuration
- Paraneoplastic autonomic dysfunction
- Paraneoplastic cerebellar degeneration
- Paraneoplastic encephalitis
- Paraneoplastic encephalomyelitis
- Paraneoplastic fever
- Paraneoplastic hypertrophic osteoarthropathy
- Paraneoplastic hypokalemia
- Paraneoplastic hyponatremia
- Paraneoplastic isolated brainstem encephalitis
- Paraneoplastic limbic encephalitis
- Paraneoplastic motor neurone disease
- Paraneoplastic myoclonus
- Paraneoplastic myositis
- Paraneoplastic neuropathy
- Paraneoplastic opsoclonus myoclonus syndrome
- Paraneoplastic peripheral neuropathy
- Paraneoplastic pruritus
- Paraneoplastic retinopathy
- Paraneoplastic sensorimotor neuropathy
- Paraneoplastic sensory neuropathy
- Paraneoplastic subacute necrotic myelopathy
- Paraneoplastic syndrome
- Paraneoplastic uveitis
- Paraneoplastic vasculitis
- Partial obstructing tumor
- Pathologic fracture of ankle at site of neoplasm
- Pathologic fracture of bone at site of neoplasm
- Pathologic fracture of bone of foot at site of neoplasm
- Pathologic fracture of bone of hand at site of neoplasm
- Pathologic fracture of cervical vertebra at site of neoplasm
- Pathologic fracture of clavicle at site of neoplasm
- Pathologic fracture of femur at site of neoplasm
- Pathologic fracture of fibula at site of neoplasm
- Pathologic fracture of humerus at site of neoplasm
- Pathologic fracture of lumbar vertebra at site of neoplasm
- Pathologic fracture of pelvis at site of neoplasm
- Pathologic fracture of proximal femur at site of neoplasm
- Pathologic fracture of radius at site of neoplasm
- Pathologic fracture of sacral vertebra at site of neoplasm
- Pathologic fracture of scapula at site of neoplasm
- Pathologic fracture of tibia at site of neoplasm
- Pathologic fracture of ulna at site of neoplasm
- Pathologic fracture of vertebra at site of neoplasm
- Pathological fracture - hand
- Pathological fracture - upper arm
- Pathological fracture of ankle
- Pathological fracture of cervical vertebra
- Pathological fracture of clavicle
- Pathological fracture of fibula
- Pathological fracture of left humerus
- Pathological fracture of left humerus due to neoplasm
- Pathological fracture of lumbar vertebra
- Pathological fracture of pelvis
- Pathological fracture of proximal end of femur
- Pathological fracture of radius
- Pathological fracture of right humerus
- Pathological fracture of right humerus due to neoplasm
- Pathological fracture of sacral vertebra
- Pathological fracture of scapula
- Pathological fracture of thoracic vertebra
- Pathological fracture of thoracic vertebra due to neoplastic disease
- Pathological fracture of tibia
- Pathological fracture of ulna
- Pathological fracture of vertebra
- Pathology examination findings indeterminate
- Pericarditis due to neoplasia
- Peritumoral lymphocytic response finding
- Pigmented tumor
- Plasma cell dyscrasia with polyneuropathy
- Pleura, bronchial surgical margin, involved by tumor
- Pleura, chest wall surgical margin, involved by tumor
- Pleura, diaphragmatic surgical margin, involved by tumor
- Pleura, esophageal surgical margin, involved by tumor
- Pleura, extrapleural chest wall surgical margin, involved by tumor
- Pleura, mediastinal surgical margin, involved by tumor
- Pleura, pericardial surgical margin, involved by tumor
- Pleura, pulmonary vascular surgical margin, involved by tumor
- Pleura, tracheal surgical margin, involved by tumor
- Pleura, vertebral body surgical margin, involved by tumor
- Pleural effusion due to another disorder
- Pleural effusion due to neoplastic disease
- Pleural surgical margin, involved by tumor
- Polymyositis
- Posterior cord syndrome due to neoplasm
- Postoperative presence of residual neoplasm following excision of neoplasm
- Postoperative unintended residual tumor following excision of tumor
- Primary site synchronous tumor finding
- Primary site synchronous tumors present
- Progesterone receptor negative neoplasm
- Progesterone receptor positive neoplasm
- Prolactin receptor positive neoplasm
- Prostate surgical margin, involved by tumor
- Prostate, apical surgical margin, involved by tumor
- Prostate, deep radial surgical margin, involved by tumor
- Prostate, seminal vesicle base surgical margin, involved by tumor
- Prostate, urethral surgical margin, involved by tumor
- Protruding tumor lesion
- Proximal pancreatic surgical margin, involved by tumor
- Proximal renal margin, partial nephrectomy only, involved by tumor
- Proximal ureteral surgical margin, involved by tumor
- Pulmonary venous hypertension due to compression of pulmonary great vein
- Pulmonary venous hypertension due to compression of pulmonary great vein by neoplasm
- Pushing tumor border
- Radiculopathy due to neoplastic disease
- Raised tumor
- Rectum, deep surgical margin, focal, involved by tumor
- Rectum, deep surgical margin, involved by tumor
- Rectum, deep surgical margin, multifocal, involved by tumor
- Rectum, inferior lateral surgical margin, involved by tumor
- Rectum, lateral surgical margin, involved by tumor
- Rectum, left lateral surgical margin, involved by tumor
- Rectum, right lateral surgical margin, involved by tumor
- Rectum, superior lateral surgical margin, involved by tumor
- Rectum, unknown surgical margin, involved by tumor
- Recurrent neoplasm
- Regional lymph nodes cannot be assessed
- Regression involving 75 percent or more of tumor, present
- Regression involving less than 75 percent of tumor, present
- Regression of tumor absent
- Renal capsular surgical margin, involved by tumor
- Renal pelvis surgical margin, involved by tumor
- Residual tumor present
- Restriction of coronary artery orifice due to neoplasm
- Right parametrial surgical margin, involved by tumor
- Right ventricular outflow tract obstruction due to neoplasm
- Rupture of neoplasm
- Secondary cerebellar degeneration
- Secondary cutaneous vasculitis
- Seminal vesicle absent in tumor specimen
- Sequelae of neoplastic diseases
- Size of base of tumor on transillumination cannot be determined
- Small tumor
- Solid tumor configuration
- Solid, entirely encapsulated tumor
- Solid, partially encapsulated tumor
- Specimen involvement by macroscopic tumor present
- Spinal cord compression due to neoplasm
- Stomach surgical margin, involved by tumor
- Stomach, distal surgical margin, involved by tumor
- Stomach, mesenteric surgical margin, involved by tumor
- Stomach, proximal surgical margin, involved by tumor
- Subacute necrotic myelopathy
- Surgical bronchial margin involved by tumor
- Surgical circumferential margin finding
- Surgical circumferential margin involvement by tumor cannot be assessed
- Surgical circumferential margin involvement by tumor not applicable
- Surgical deep margin involvement by tumor cannot be assessed
- Surgical distal margin involved by tumor
- Surgical distal margin involvement by tumor cannot be assessed
- Surgical lateral margin involved by tumor
- Surgical margin involved by tumor
- Surgical margin involvement by tumor absent
- Surgical margin involvement by tumor cannot be assessed
- Surgical margin involvement by tumor indeterminate
- Surgical margin involvement by tumor not applicable
- Surgical margin of optic nerve involved by tumor
- Surgical margin of renal vessel involved by tumor
- Surgical margin uninvolved by tumor
- Surgical posterior retroperitoneal pancreatic margin involved by tumor
- Surgical spermatic cord margin involved by tumor
- Surgical spermatic cord margin involvement by tumor cannot be assessed
- Surgical spermatic cord margin uninvolved by tumor
- Testis surgical margin, involved by tumor
- Thrombosis of inferior vena cava
- Thrombosis of vena cava
- Thyroid surgical margin, involved by tumor
- Tissue specimen fragmented
- Trophoblast, hysterectomy cervical/vaginal surgical margin, involved by tumor
- Trophoblast, hysterectomy surgical margin, involved by tumor
- Tumor border behavior finding
- Tumor calcification
- Tumor configuration
- Tumor configuration cannot be determined
- Tumor confined within capsule
- Tumor contained within organ capsule
- Tumor embolus
- Tumor extends to organ capsule
- Tumor flare
- Tumor hyperprogression
- Tumor infiltration by lymphocytes absent
- Tumor infiltration by lymphocytes brisk
- Tumor infiltration by lymphocytes non-brisk
- Tumor infiltration by lymphocytes present
- Tumor involvement of noncontiguous structures absent
- Tumor location after sectioning cannot be determined
- Tumor metastasis to non-regional lymph nodes not applicable
- Tumor necrosis absent
- Tumor necrosis cannot be determined
- Tumor nodule site cannot be assessed
- Tumor nodule size cannot be assessed
- Tumor of advanced extent
- Tumor of indeterminate configuration
- Tumor of minimal extent
- Tumor of moderate extent
- Tumor of unknown origin
- Tumor pigmentation cannot be determined
- Tumor pigmentation indeterminate
- Tumor pigmentation, diffuse
- Tumor pigmentation, patchy/focal
- Tumor progression
- Tumor pseudoprogression
- Tumor regression finding
- Tumor site cannot be determined
- Tumor site indeterminate
- Tumor site not applicable
- Tumor site not specified
- Tumor size after sectioning cannot be determined
- Tumor size cannot be assessed
- Tumor size cannot be assessed, specimen fragmented
- Tumor size finding
- Tumor size not applicable
- Tumor size, invasive component, cannot be determined
- Tumor stage cannot be determined
- Tumor surgically resectable
- Tumor surgically unresectable
- Tumor thrombus of inferior vena cava
- Tumor ulceration absent
- Ulcerated tumor configuration
- Unifocal tumor
- Unpigmented tumor
- Upper aerodigestive tract surgical margin, involved by tumor
- Ureter, renal pelvis surgical margin, involved by tumor
- Ureteral surgical margin, involved by tumor
- Uterine cervix surgical margin, involved by tumor
- Vaginal surgical margin, involved by tumor
- Vascularization of tumor tissue
- Very large tumor
- Viable tumor present in specimen
- Visual cortex disorder due to neoplasm
- Visual pathway disorder due to neoplasm
- Vitreous cells
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D49.9: its own notes plus those printed at D49 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- 'growth' NOS
- neoplasm NOS
- new growth NOS
- tumor NOS
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D49.9, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming D49.9: they are not reported together with it, unless the two conditions are unrelated.
- Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesneoplasms of unspecified behavior (D49.-) names D49.-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Arthropathy See Also: Arthritis; M12.9
neoplastic disease See Also: Neoplasm; D49.9
systemic affecting central nervous system
neoplastic disease See Also: Neoplasm; D49.9
nerve See Also: Disorder, nerve; G58.9
neoplastic disease See Also: Neoplasm; D49.9
Dermatomyositis (acute) (chronic) See Also: Dermatopolymyositis;
in (due to) neoplastic disease See Also: Neoplasm; D49.9
in neoplastic disease See Also: Neoplasm; D49.9
neoplastic disease See Also: Neoplasm; D49.9
Myelopathy (spinal cord) G95.9
neoplastic disease See Also: Neoplasm; D49.9
Osteitis See Also: Osteomyelitis;
deformans See Also: Paget's disease, bone; M88.9
neoplastic disease See Also: Neoplasm, by type and site; D49.9
Palsy See Also: Paralysis; G83.9
cranial nerve See Also: Disorder, nerve, cranial;
neoplastic disease See Also: Neoplasm; D49.9
Polyneuropathy (peripheral) G62.9
neoplastic disease See Also: Neoplasm; D49.9
Syndrome See Also: Disease;
neoplastic disease See Also: Neoplasm; D49.9
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
CCSR NEO072
Neoplasms of unspecified nature or uncertain behavior
Default principal diagnosis: inpatient Yes · outpatient Yes
Table of NeoplasmsClinical
Convert D49.9 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.
Questions About D49.9Overview
What is the ICD-10 code for neoplasm of unspecified behavior of unspecified site?
The ICD-10-CM code for neoplasm of unspecified behavior of unspecified site is D49.9 (sometimes written as D499). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D49.9 (Neoplasms of unspecified behavior) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of unspecified site on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D49.9 group to?
When neoplasm of unspecified behavior of unspecified site is the principal diagnosis on an inpatient stay, it groups to MS-DRG 844, 827, 829, 843, 828, 826, 830, 845, with relative weights from 0.8443 to 4.7560 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D49.9?
Under the General Equivalence Mappings, neoplasm of unspecified behavior of unspecified site converts to ICD-9-CM 239.9 (neoplasm NOS). The mapping is a direct match.
