2026 ICD-10-CM Diagnosis Code D49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system

ICD-10-CM CodesD50–D89D49D49

ICD-10-CM D49.7
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D49.7 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of endocrine glands and other parts of nervous system. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.

Code Identity

ICD-10-CM Code
D49.7
Billable Status
Yes — Valid for Submission
Code Describes
Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system
Short Description
Neoplm of unsp behav of endo glands and oth prt nervous sys
Parent Code
Neoplasms of unspecified behavior

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD49Neoplasms of unspecified behavior
CategoryD49Neoplasms of unspecified behavior
This CodeD49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adrenal Cushing's syndrome
  • Adrenal incidentaloma
  • Adrenal surgical margin, involved by tumor
  • Carney triad
  • Cerebrospinal fluid rhinorrhea
  • Cerebrospinal fluid rhinorrhea due to pituitary tumor
  • Disorder of olfactory nerve
  • Disorder of visual pathways associated with neoplasm
  • Follicular neoplasm of thyroid
  • Functioning pituitary neoplasm
  • Functionless pituitary neoplasm
  • Glial tumor of spinal cord
  • Hypercortisolism due to adrenal neoplasm
  • Hypopituitarism due to pituitary neoplasm
  • Incidentaloma of thyroid gland
  • Neoplasm of abducens nerve
  • Neoplasm of accessory nerve
  • Neoplasm of adrenal cortex
  • Neoplasm of adrenal gland
  • Neoplasm of adrenal medulla
  • Neoplasm of aortic body
  • Neoplasm of brain meninges
  • Neoplasm of carotid body
  • Neoplasm of cauda equina
  • Neoplasm of central nervous system
  • Neoplasm of cranial nerve
  • Neoplasm of craniopharyngeal duct
  • Neoplasm of endocrine gland
  • Neoplasm of endocrine system
  • Neoplasm of extradural space
  • Neoplasm of facial nerve
  • Neoplasm of glomus jugulare
  • Neoplasm of glossopharyngeal nerve
  • Neoplasm of hypoglossal nerve
  • Neoplasm of lumbar spinal nerve
  • Neoplasm of meninges
  • Neoplasm of multiple endocrine glands
  • Neoplasm of nerve sheath origin
  • Neoplasm of nervous system
  • Neoplasm of oculomotor nerve
  • Neoplasm of olfactory nerve
  • Neoplasm of optic nerve
  • Neoplasm of optic nerve and sheath
  • Neoplasm of para-aortic body
  • Neoplasm of paraganglion
  • Neoplasm of parathyroid gland
  • Neoplasm of peripheral nerves of neck
  • Neoplasm of pineal gland
  • Neoplasm of pituitary and suprasellar region
  • Neoplasm of pituitary gland
  • Neoplasm of sacral spinal nerve
  • Neoplasm of spinal cord
  • Neoplasm of spinal meninges
  • Neoplasm of thoracic spinal nerve
  • Neoplasm of thyroglossal duct
  • Neoplasm of thyroid gland
  • Neoplasm of trigeminal nerve
  • Neoplasm of trochlear nerve
  • Neoplasm of vagus nerve
  • Neoplasm of vestibulocochlear nerve
  • Virilizing adrenal tumor
  • Virilizing syndrome of adrenal origin
  • WHO grade finding for central nervous system tumor
  • WHO grade I
  • WHO grade II
  • WHO grade III
  • WHO grade IV

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • neoplasm of unspecified behavior of peripheral, sympathetic, and parasympathetic nerves and ganglia D49.2

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO072
Neoplasms of unspecified nature or uncertain behavior
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Arachnoid

    a delicate membrane enveloping the brain and spinal cord. it lies between the pia mater and the dura mater. it is separated from the pia mater by the subarachnoid cavity which is filled with cerebrospinal fluid.
  • Arachnoid Cysts

    intracranial or spinal cavities containing a cerebrospinal-like fluid, the wall of which is composed of arachnoidal cells. they are most often developmental or related to trauma. intracranial arachnoid cysts usually occur adjacent to arachnoidal cistern and may present with hydrocephalus; headache; seizures; and focal neurologic signs. (from joynt, clinical neurology, 1994, ch44, pp105-115)
  • Arachnoiditis

    acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. this term generally refers to a persistent inflammatory process characterized by thickening of the arachnoid membrane and dural adhesions. associated conditions include prior surgery, infections, trauma, subarachnoid hemorrhage, and chemical irritation. clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (from joynt, clinical neurology, 1997, ch48, p25)
  • Medulloblastoma

    a malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see neuroectodermal tumor, primitive). the tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (from devita et al., cancer: principles and practice of oncology, 5th ed, pp2060-1)
  • Cauda Equina

    the lower part of the spinal cord consisting of the lumbar, sacral, and coccygeal nerve roots.
  • Cauda Equina Syndrome

    compressive lesion affecting the nerve roots of the cauda equina (e.g., compression, herniation, inflammation, rupture, or stenosis), which controls the function of the bladder and bowel. symptoms may include neurological dysfunction of bladder or bowels, loss of sexual sensation and altered sensation or paralysis in the lower extremities.
  • Meninges

    the three membranes that cover the brain and the spinal cord. they are the dura mater, the arachnoid, and the pia mater.
  • Meningocele

    a congenital or acquired protrusion of the meninges, unaccompanied by neural tissue, through a bony defect in the skull or vertebral column.
  • Pia Mater

    the innermost layer of the three meninges covering the brain and spinal cord. it is the fine vascular membrane that lies under the arachnoid and the dura mater.
  • Empty Sella Syndrome

    a condition when the sella turcica is not filled with pituitary tissue. the pituitary gland is either compressed, atrophied, or removed. there are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of pituitary neoplasms.
  • Sella Turcica

    a bony prominence situated on the upper surface of the body of the sphenoid bone. it houses the pituitary gland.
  • Cerebrospinal Fluid Rhinorrhea

    discharge of cerebrospinal fluid through the nose. common etiologies include trauma, neoplasms, and prior surgery, although the condition may occur spontaneously. (otolaryngol head neck surg 1997 apr;116(4):442-9)
  • Cerebrospinal Fluid Rhinorrhea

    discharge of cerebrospinal fluid through the nose.

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary
Malig.
Secondary
Ca
in situ
BenignUncertainUnspec.
acoustic nerveC72.4C79.49D33.3D43.3D49.7
adrenalC74.9C79.7D09.3D35.0D44.1D49.7
adrenal capsuleC74.9C79.7D09.3D35.0D44.1D49.7
adrenal cortexC74.0C79.7D09.3D35.0D44.1D49.7
adrenal glandC74.9C79.7D09.3D35.0D44.1D49.7
adrenal medullaC74.1C79.7D09.3D35.0D44.1D49.7
aortic bodyC75.5C79.89D35.6D44.7D49.7
arachnoidC70.9C79.49D32.9D42.9D49.7
arachnoid cerebralC70.0C79.32D32.0D42.0D49.7
arachnoid spinalC70.1C79.49D32.1D42.1D49.7
auditory nerveC72.4C79.49D33.3D43.3D49.7
brain NEC meningesC70.0C79.32D32.0D42.0D49.7
carotid (artery) bodyC75.4C79.89D35.5D44.6D49.7
cauda equinaC72.1C79.49D33.4D43.4D49.7
cerebrum, cerebral (cortex) (hemisphere) (white matter) meningesC70.0C79.32D32.0D42.0D49.7
chiasma opticumC72.3C79.49D33.3D43.3D49.7
conus medullarisC72.0C79.49D33.4D43.4D49.7
cord (true) (vocal) spinal (cervical) (lumbar) (thoracic)C72.0C79.49D33.4D43.4D49.7
cortexC74.0C79.7D09.3D35.0D44.1D49.7
cortex adrenalC74.0C79.7D09.3D35.0D44.1D49.7
cranial (fossa, any) meningesC70.0C79.32D32.0D42.0D49.7
cranial (fossa, any) nerveC72.50C79.49D33.3D43.3D49.7
cranial (fossa, any) nerve specified NECC72.59C79.49D33.3D43.3D49.7
craniobuccal pouchC75.2C79.89D09.3D35.2D44.3D49.7
craniopharyngeal (duct) (pouch)C75.2C79.89D09.3D35.3D44.4D49.7
dura (cranial) (mater)C70.9C79.49D32.9D42.9D49.7
dura (cranial) (mater) cerebralC70.0C79.32D32.0D42.0D49.7
dura (cranial) (mater) spinalC70.1C79.49D32.1D42.1D49.7
endocrine gland NECC75.9C79.89D09.3D35.9D44.9D49.7
endocrine gland NEC pluriglandularC75.8C79.89D09.3D35.7D44.9D49.7
epiduralC72.9C79.49D33.9D43.9D49.7
extraduralC72.9C79.49D33.9D43.9D49.7
falx (cerebella) (cerebri)C70.0C79.32D32.0D42.0D49.7
filum terminaleC72.0C79.49D33.4D43.4D49.7
fossa (of) pituitaryC75.1C79.89D09.3D35.2D44.3D49.7
ganglia [See Also: Neoplasm, nerve, peripheral] cranial nerveC72.50C79.49D33.3D43.3D49.7
gland, glandular (lymphatic) (system) [See Also: Neoplasm, lymph gland]C75.9C79.89D09.3D35.9D44.9D49.7
gland, glandular (lymphatic) (system) [See Also: Neoplasm, lymph gland] endocrine NECC75.9C79.89D09.3D35.9D44.9D49.7
glomus jugularisC75.5C79.89D35.6D44.7D49.7
hypophysisC75.1C79.89D09.3D35.2D44.3D49.7
intrasellarC75.1C79.89D09.3D35.2D44.3D49.7
medullaC74.1C79.7D09.3D35.0D44.1D49.7
medulla adrenalC74.1C79.7D09.3D35.0D44.1D49.7
meningesC70.9C79.49D32.9D42.9D49.7
meninges brainC70.0C79.32D32.0D42.0D49.7
meninges cerebralC70.0C79.32D32.0D42.0D49.7
meninges cranialC70.0C79.32D32.0D42.0D49.7
meninges intracranialC70.0C79.32D32.0D42.0D49.7
meninges spinal (cord)C70.1C79.49D32.1D42.1D49.7
motor tractC72.9C79.49D33.9D43.9D49.7
motor tract cauda equinaC72.1C79.49D33.4D43.4D49.7
motor tract spinalC72.0C79.49D33.4D43.4D49.7
nerve (ganglion) abducensC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) accessory (spinal)C72.59C79.49D33.3D43.3D49.7
nerve (ganglion) acousticC72.4C79.49D33.3D43.3D49.7
nerve (ganglion) auditoryC72.4C79.49D33.3D43.3D49.7
nerve (ganglion) cranialC72.50C79.49D33.3D43.3D49.7
nerve (ganglion) cranial specified NECC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) facialC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) glossopharyngealC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) hypoglossalC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) oculomotorC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) olfactoryC47.2C79.49D33.3D43.3D49.7
nerve (ganglion) opticC72.3C79.49D33.3D43.3D49.7
nerve (ganglion) spinal NEC accessoryC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) trigeminalC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) trochlearC72.59C79.49D33.3D43.3D49.7
nerve (ganglion) vagusC72.59C79.49D33.3D43.3D49.7
nervous system (central)C72.9C79.40D33.9D43.9D49.7
olfactory nerve or bulbC72.2C79.49D33.3D43.3D49.7
optic nerve, chiasm, or tractC72.3C79.49D33.3D43.3D49.7
organ of ZuckerkandlC75.5C79.89D35.6D44.7D49.7
para-aortic bodyC75.5C79.89D35.6D44.7D49.7
paraganglion NECC75.5C79.89D35.6D44.7D49.7
parasellarC72.9C79.49D33.9D43.8D49.7
parathyroid (gland)C75.0C79.89D09.3D35.1D44.2D49.7
pia materC70.9C79.40D32.9D42.9D49.7
pia mater cerebralC70.0C79.32D32.0D42.0D49.7
pia mater cranialC70.0C79.32D32.0D42.0D49.7
pia mater spinalC70.1C79.49D32.1D42.1D49.7
pineal (body) (gland)C75.3C79.89D09.3D35.4D44.5D49.7
pituitary (body) (fossa) (gland) (lobe)C75.1C79.89D09.3D35.2D44.3D49.7
pluriendocrineC75.8C79.89D09.3D35.7D44.9D49.7
Rathke's pouchC75.1C79.89D09.3D35.2D44.3D49.7
sella turcicaC75.1C79.89D09.3D35.2D44.3D49.7
spine, spinal (column) cord (cervical) (lumbar) (sacral) (thoracic)C72.0C79.49D33.4D43.4D49.7
spine, spinal (column) dura materC70.1C79.49D32.1D42.1D49.7
spine, spinal (column) membraneC70.1C79.49D32.1D42.1D49.7
spine, spinal (column) meningesC70.1C79.49D32.1D42.1D49.7
spine, spinal (column) pia materC70.1C79.49D32.1D42.1D49.7
subduralC70.9C79.32D32.9D42.9D49.7
suprarenalC74.9C79.7D09.3D35.0D44.1D49.7
suprarenal capsuleC74.9C79.7D09.3D35.0D44.1D49.7
suprarenal cortexC74.0C79.7D09.3D35.0D44.1D49.7
suprarenal glandC74.9C79.7D09.3D35.0D44.1D49.7
suprarenal medullaC74.1C79.7D09.3D35.0D44.1D49.7
tentorium (cerebelli)C70.0C79.32D32.0D42.0D49.7
thyroglossal ductC73C79.89D09.3D34D44.0D49.7
thyroid (gland)C73C79.89D09.3D34D44.0D49.7
Zuckerkandl organC75.5C79.89D35.6D44.7D49.7

Convert D49.7 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
239.7 Endocrine/nerv neo NOS
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D49.7Overview

Is D49.7 (Neoplasms of unspecified behavior) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of endocrine glands and other parts of nervous system on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D49.7 group to?

When neoplasm of unspecified behavior of endocrine glands and other parts of nervous system is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D49.7?

Under the General Equivalence Mappings, neoplasm of unspecified behavior of endocrine glands and other parts of nervous system converts to ICD-9-CM 239.7 (endocrine/nerv neo NOS). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.