2027 ICD-10-CM Diagnosis Code D49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system
ICD-10-CM Codes›C00–D49›D49›D49
- Billable — Valid for Submission
- Not Chronic
D49.7 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of endocrine glands and other parts of nervous system. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adrenal Cushing's syndrome
- Adrenal incidentaloma
- Adrenal surgical margin, involved by tumor
- Carney triad
- Cerebrospinal fluid rhinorrhea
- Cerebrospinal fluid rhinorrhea due to pituitary tumor
- Disorder of olfactory nerve
- Disorder of visual pathways associated with neoplasm
- Follicular neoplasm of thyroid
- Functioning pituitary neoplasm
- Functionless pituitary neoplasm
- Hypercortisolism due to adrenal neoplasm
- Hypopituitarism due to pituitary neoplasm
- Incidentaloma of thyroid gland
- Meningioma
- Neoplasm of abducens nerve
- Neoplasm of accessory nerve
- Neoplasm of adrenal cortex
- Neoplasm of adrenal gland
- Neoplasm of adrenal medulla
- Neoplasm of aortic body
- Neoplasm of brain meninges
- Neoplasm of carotid body
- Neoplasm of cauda equina
- Neoplasm of central nervous system
- Neoplasm of cranial nerve
- Neoplasm of craniopharyngeal duct
- Neoplasm of endocrine gland
- Neoplasm of endocrine system
- Neoplasm of extradural space
- Neoplasm of facial nerve
- Neoplasm of glomus jugulare
- Neoplasm of glossopharyngeal nerve
- Neoplasm of hypoglossal nerve
- Neoplasm of lumbar spinal nerve
- Neoplasm of meninges
- Neoplasm of multiple endocrine glands
- Neoplasm of nerve sheath origin
- Neoplasm of nervous system
- Neoplasm of oculomotor nerve
- Neoplasm of olfactory nerve
- Neoplasm of optic nerve
- Neoplasm of optic nerve and sheath
- Neoplasm of para-aortic body
- Neoplasm of paraganglion
- Neoplasm of parathyroid gland
- Neoplasm of peripheral nerves of neck
- Neoplasm of pineal gland
- Neoplasm of pituitary and suprasellar region
- Neoplasm of pituitary gland
- Neoplasm of sacral spinal nerve
- Neoplasm of spinal cord
- Neoplasm of spinal meninges
- Neoplasm of thoracic spinal nerve
- Neoplasm of thyroglossal duct
- Neoplasm of thyroid gland
- Neoplasm of trigeminal nerve
- Neoplasm of trochlear nerve
- Neoplasm of vagus nerve
- Neoplasm of vestibulocochlear nerve
- Structural abnormality of glossopharyngeal nerve
- Virilizing adrenal neoplasm
- Virilizing syndrome of adrenal origin
- WHO grade finding for central nervous system tumor
- WHO grade I
- WHO grade II
- WHO grade III
- WHO grade IV
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D49.7: its own notes plus those printed at D49 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- 'growth' NOS
- neoplasm NOS
- new growth NOS
- tumor NOS
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- neoplasm of unspecified behavior of peripheral, sympathetic, and parasympathetic nerves and ganglia (D49.2)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D49.7, its category, or a range that includes it.
Excludes1 4
These codes carry an Excludes1 note naming D49.7: they are not reported together with it, unless the two conditions are unrelated.
- D49.6 Neoplasm of unspecified behavior of brainneoplasm of unspecified behavior of cerebral meninges (D49.7)
- D49.6 Neoplasm of unspecified behavior of brainneoplasm of unspecified behavior of cranial nerves (D49.7)
- D49.8 Neoplasm of unspecified behavior of other specified sitesneoplasm of unspecified behavior of optic nerve (D49.7)
- Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesneoplasms of unspecified behavior (D49.-) names D49.-, which includes this code
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| acoustic nerve | C72.4 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| adrenal | C74.9 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| adrenal › capsule | C74.9 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| adrenal › cortex | C74.0 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| adrenal › gland | C74.9 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| adrenal › medulla | C74.1 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| aortic body | C75.5 | C79.89 | – | D35.6 | D44.7 | D49.7 |
| arachnoid | C70.9 | C79.49 | – | D32.9 | D42.9 | D49.7 |
| arachnoid › cerebral | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| arachnoid › spinal | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| auditory › nerve | C72.4 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| brain NEC › meninges | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| carotid (artery) › body | C75.4 | C79.89 | – | D35.5 | D44.6 | D49.7 |
| cauda equina | C72.1 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| cerebrum, cerebral (cortex) (hemisphere) (white matter) › meninges | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| chiasma opticum | C72.3 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| conus medullaris | C72.0 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| cord (true) (vocal) › spinal (cervical) (lumbar) (thoracic) | C72.0 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| cortex › adrenal | C74.0 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| cranial (fossa, any) › meninges | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| cranial (fossa, any) › nerve | C72.50 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| cranial (fossa, any) › nerve › specified NEC | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| craniobuccal pouch | C75.2 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| craniopharyngeal (duct) (pouch) | C75.2 | C79.89 | D09.3 | D35.3 | D44.4 | D49.7 |
| dura (cranial) (mater) | C70.9 | C79.49 | – | D32.9 | D42.9 | D49.7 |
| dura (cranial) (mater) › cerebral | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| dura (cranial) (mater) › spinal | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| endocrine gland NEC | C75.9 | C79.89 | D09.3 | D35.9 | D44.9 | D49.7 |
| endocrine gland NEC › pluriglandular | C75.8 | C79.89 | D09.3 | D35.7 | D44.9 | D49.7 |
| epidural | C72.9 | C79.49 | – | D33.9 | D43.9 | D49.7 |
| extradural | C72.9 | C79.49 | – | D33.9 | D43.9 | D49.7 |
| falx (cerebella) (cerebri) | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| filum terminale | C72.0 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| fossa (of) › pituitary | C75.1 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| ganglia [See Also: Neoplasm, nerve, peripheral] › cranial nerve | C72.50 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| gland, glandular (lymphatic) (system) [See Also: Neoplasm, lymph gland] › endocrine NEC | C75.9 | C79.89 | D09.3 | D35.9 | D44.9 | D49.7 |
| glomus › jugularis | C75.5 | C79.89 | – | D35.6 | D44.7 | D49.7 |
| hypophysis | C75.1 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| intrasellar | C75.1 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| medulla › adrenal | C74.1 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| meninges | C70.9 | C79.49 | – | D32.9 | D42.9 | D49.7 |
| meninges › brain | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| meninges › cerebral | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| meninges › cranial | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| meninges › intracranial | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| meninges › spinal (cord) | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| motor tract | C72.9 | C79.49 | – | D33.9 | D43.9 | D49.7 |
| motor tract › cauda equina | C72.1 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| motor tract › spinal | C72.0 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| nerve (ganglion) › abducens | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › accessory (spinal) | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › acoustic | C72.4 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › auditory | C72.4 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › cranial | C72.50 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › cranial › specified NEC | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › facial | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › glossopharyngeal | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › hypoglossal | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › oculomotor | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › olfactory | C47.2 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › optic | C72.3 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › spinal NEC › accessory | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › trigeminal | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › trochlear | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nerve (ganglion) › vagus | C72.59 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| nervous system (central) | C72.9 | C79.40 | – | D33.9 | D43.9 | D49.7 |
| olfactory nerve or bulb | C72.2 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| optic nerve, chiasm, or tract | C72.3 | C79.49 | – | D33.3 | D43.3 | D49.7 |
| organ of Zuckerkandl | C75.5 | C79.89 | – | D35.6 | D44.7 | D49.7 |
| para-aortic body | C75.5 | C79.89 | – | D35.6 | D44.7 | D49.7 |
| paraganglion NEC | C75.5 | C79.89 | – | D35.6 | D44.7 | D49.7 |
| parasellar | C72.9 | C79.49 | – | D33.9 | D43.8 | D49.7 |
| parathyroid (gland) | C75.0 | C79.89 | D09.3 | D35.1 | D44.2 | D49.7 |
| pia mater | C70.9 | C79.40 | – | D32.9 | D42.9 | D49.7 |
| pia mater › cerebral | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| pia mater › cranial | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| pia mater › spinal | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| pineal (body) (gland) | C75.3 | C79.89 | D09.3 | D35.4 | D44.5 | D49.7 |
| pituitary (body) (fossa) (gland) (lobe) | C75.1 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| pluriendocrine | C75.8 | C79.89 | D09.3 | D35.7 | D44.9 | D49.7 |
| Rathke's pouch | C75.1 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| sella turcica | C75.1 | C79.89 | D09.3 | D35.2 | D44.3 | D49.7 |
| spine, spinal (column) › cord (cervical) (lumbar) (sacral) (thoracic) | C72.0 | C79.49 | – | D33.4 | D43.4 | D49.7 |
| spine, spinal (column) › dura mater | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| spine, spinal (column) › membrane | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| spine, spinal (column) › meninges | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| spine, spinal (column) › pia mater | C70.1 | C79.49 | – | D32.1 | D42.1 | D49.7 |
| subdural | C70.9 | C79.32 | – | D32.9 | D42.9 | D49.7 |
| suprarenal | C74.9 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| suprarenal › capsule | C74.9 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| suprarenal › cortex | C74.0 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| suprarenal › gland | C74.9 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| suprarenal › medulla | C74.1 | C79.7 | D09.3 | D35.0 | D44.1 | D49.7 |
| tentorium (cerebelli) | C70.0 | C79.32 | – | D32.0 | D42.0 | D49.7 |
| thyroglossal duct | C73 | C79.89 | D09.3 | D34 | D44.0 | D49.7 |
| thyroid (gland) | C73 | C79.89 | D09.3 | D34 | D44.0 | D49.7 |
| Zuckerkandl organ | C75.5 | C79.89 | – | D35.6 | D44.7 | D49.7 |
Convert D49.7 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D49.7Overview
Is D49.7 (Neoplasms of unspecified behavior) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of endocrine glands and other parts of nervous system on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D49.7 group to?
When neoplasm of unspecified behavior of endocrine glands and other parts of nervous system is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D49.7 be reported with D49.2?
Not as a rule. The Excludes1 note on D49.7 lists "neoplasm of unspecified behavior of peripheral, sympathetic, and parasympathetic nerves and ganglia (D49.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D49.7?
Under the General Equivalence Mappings, neoplasm of unspecified behavior of endocrine glands and other parts of nervous system converts to ICD-9-CM 239.7 (endocrine/nerv neo NOS). The mapping is a direct match.
