2024 ICD-10-CM Diagnosis Code C75.0
Malignant neoplasm of parathyroid gland
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Adenocarcinoma of parathyroid gland
- Malignant tumor of parathyroid gland
- Parathyroid carcinoma
- Primary adenocarcinoma of parathyroid gland
- Primary malignant neoplasm of parathyroid gland
Clinical Category is Endocrine system cancers - parathyroid
- CCSR Category Code: NEO054
- Inpatient Default CCSR: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.
- Outpatient Default CCSR: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.
Index to Diseases and Injuries References
The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).
Table of Neoplasms
This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.
Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.
Head and Neck Cancer
What is head and neck cancer?
Head and neck cancer is the name for cancers that develop in the mouth, nose and sinuses, salivary glands, and throat and voice box (larynx). Most head and neck cancers are squamous cell cancers. They begin in the moist tissues that line the head and neck. The cancer cells may spread into deeper tissue as the cancer grows.
There are other cancers that develop in the head and neck, such as brain cancer, eye cancer, and esophageal cancer. But they are usually not considered to be head and neck cancers, because those types of cancer and their treatments are different.
Who is more likely to develop head and neck cancer?
Anyone can get head and neck cancer, but you are more likely to develop it if you:
- Use tobacco or drink lots of alcohol. Your risk of developing head and neck cancer is even higher if you do both.
- Are male.
- Are over age 50.
- Have a history of head or neck cancer.
- Have HPV (for cancers in the tonsils and base of the tongue).
- Are exposed to wood dusts or certain other toxic substances at work (for upper throat, nose, and sinus cancers).
- Have had radiation exposure to the head and neck (for salivary gland cancer).
- Have Epstein-Barr virus (EBV) infection (for upper throat and salivary gland cancers).
- Are Asian (for upper throat cancer).
What are the symptoms of head and neck cancer?
The symptoms of head and neck cancer may include:
- A lump in the neck
- A sore in the mouth or the throat that does not heal and may be painful
- A sore throat that does not go away
- Trouble swallowing
- A change or hoarseness in the voice
Other possible symptoms can depend on the specific type of head and neck cancer.
How is head and neck cancer diagnosed?
Which exams and tests used to diagnose head and neck cancer can depend on the specific type of cancer. Possible exams and tests may include:
- A physical exam of the area that might have cancer.
- Blood and/or urine tests.
- An endoscopy.
- A biopsy or other procedure to collect cells from the area that might have cancer. The cells are viewed under a microscope to find out if they are abnormal.
- Imaging tests.
What are the treatments for head and neck cancer?
The treatment for head and neck cancer will depend on the specific type of cancer, the stage (how advanced the cancer is), your overall health, and other factors. The treatment options might include:
- Radiation therapy
- Cancer immunotherapy
- Targeted therapy, which uses drugs or other substances that mainly attack specific cancer cells and cause less harm to normal cells
In some cases, you may need a combination of treatments. Sometimes surgery can affect how well you can chew, swallow, or talk. Rehabilitation, such as physical therapy, dietary counseling, and speech therapy, may help.
Can head and neck cancer be prevented?
There are steps you can take to help prevent head and neck cancer:
- Not smoking
- Limiting alcohol use or not drinking at all
- Getting regular dental exams
- Talking to your provider about HPV vaccination
NIH: National Cancer Institute
[Learn More in MedlinePlus]
Most people have four pea-sized glands, called parathyroid glands, on the thyroid gland in the neck. Though their names are similar, the thyroid and parathyroid glands are completely different. The parathyroid glands make parathyroid hormone (PTH), which helps your body keep the right balance of calcium and phosphorous.
If your parathyroid glands make too much or too little hormone, it disrupts this balance. If they secrete extra PTH, you have hyperparathyroidism, and your blood calcium rises. In many cases, a benign tumor on a parathyroid gland makes it overactive. Or, the extra hormones can come from enlarged parathyroid glands. Very rarely, the cause is cancer.
If you do not have enough PTH, you have hypoparathyroidism. Your blood will have too little calcium and too much phosphorous. Causes include injury to the glands, endocrine disorders, or genetic conditions. Treatment is aimed at restoring the balance of calcium and phosphorous.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
[Learn More in MedlinePlus]
Parathyroid cancer is a rare cancer that usually affects people in their forties or fifties and occurs in one of the four parathyroid glands. The parathyroid glands are located in the neck and secrete parathyroid hormone, which enhances the release of calcium into the blood.
In about 90 percent of cases, the early signs of parathyroid cancer are high levels of parathyroid hormone (hyperparathyroidism) and calcium (hypercalcemia) in the blood. In these cases, the cancer is described as hormonally functional because the parathyroid glands are producing excess hormone.
Many individuals with hormonally functional parathyroid cancer develop hypercalcemic crisis, in which calcium levels in the blood are very high. Neurological problems can develop, including changes in mood and depression. About 30 percent of individuals with hypercalcemia due to parathyroid cancer develop kidney and skeletal problems. These problems include increased urine production (polyuria), deposits of calcium in the kidneys (nephrocalcinosis) leading to the formation of kidney stones (nephrolithiasis), bone pain, bone loss, and increased bone fractures. Abdominal pain, inflammation of the pancreas (pancreatitis), sores (ulcers) in the lining of the digestive tract, nausea, vomiting, weight loss, and fatigue are also common.
About 10 percent of cases of parathyroid cancer are described as hormonally nonfunctional. In these cases, levels of parathyroid hormone and calcium are normal. The signs and symptoms of hormonally nonfunctional parathyroid cancer are related to the tumor obstructing nearby structures in the neck. These problems include difficulty swallowing (dysphagia) and speaking (dysarthria), a hoarse voice, shortness of breath (dyspnea), or vocal cord paralysis.
Up to 85 percent of individuals with parathyroid survive at least 5 years after they are diagnosed. The disease recurs in approximately half of individuals. If cancer does recur, it will commonly be within 3 years of the original diagnosis and up to 78 percent of people with recurrent cancer survive at least 5 years. Hormonally nonfunctional parathyroid cancer has a lower survival rate because it is often found at a later stage, as it does not have early signs such as increased calcium and parathyroid hormone levels.
In hormonally functional parathyroid cancer, death is usually caused by organ failure (usually kidney failure) due to prolonged hypercalcemia and not directly due to the tumor. In hormonally nonfunctional parathyroid cancer, the cause of death is typically related to the tumor itself, such as its impact on the function of nearby structures or its spread to other tissues (metastasis).
[Learn More in MedlinePlus]
- FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
- FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
- FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
- FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
- FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
- FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
- FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
- FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
- FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.
 Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.