2024 ICD-10-CM Diagnosis Code D35.2

Benign neoplasm of pituitary gland

ICD-10-CM Code:
ICD-10 Code for:
Benign neoplasm of pituitary gland
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Neoplasms
    • Benign neoplasms, except benign neuroendocrine tumors
      • Benign neoplasm of other and unspecified endocrine glands

D35.2 is a billable diagnosis code used to specify a medical diagnosis of benign neoplasm of pituitary gland. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

The following anatomical sites found in the Table of Neoplasms reference this diagnosis code given the correct histological behavior: Neoplasm, neoplastic craniobuccal pouch ; Neoplasm, neoplastic fossa (of) pituitary ; Neoplasm, neoplastic hypophysis ; Neoplasm, neoplastic intrasellar ; Neoplasm, neoplastic pituitary (body) (fossa) (gland) (lobe) ; Neoplasm, neoplastic Rathke's pouch ; Neoplasm, neoplastic sella turcica ; etc

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • ACTH-dependent Cushing's syndrome
  • Benign neoplasm of craniopharyngeal duct
  • Benign neoplasm of pituitary gland
  • Benign neoplasm of pituitary gland and craniopharyngeal duct
  • Corticotroph adenoma
  • Dermoid cyst of brain
  • Epidermoid cyst of brain
  • Epidermoid cyst of pituitary gland
  • Familial isolated pituitary adenoma
  • Functioning pituitary neoplasm
  • Functioning pituitary neoplasm
  • Functioning pituitary neoplasm
  • Functioning pituitary neoplasm
  • Functioning pituitary neoplasm
  • Functioning pituitary neoplasm
  • Functioning pituitary neoplasm
  • Functionless pituitary adenoma
  • Functionless pituitary neoplasm
  • Germ cell tumor of the brain
  • Gonadotroph adenoma
  • Granular cell tumor
  • Granular cell tumor of neurohypophysis
  • Hamartoma of brain
  • Hamartoma of hypothalamus
  • Hamartoma of pituitary and hypothalamus
  • Hypercortisolism due to pituitary adenoma
  • Hypopituitarism due to pituitary tumor
  • Invasive benign pituitary adenoma
  • Macroprolactinoma
  • Mass of neurohypophysis
  • Mass of neurohypophysis
  • Microprolactinoma
  • Mixed-functioning pituitary adenoma
  • Neoplasm of craniopharyngeal duct
  • Pituitary adenoma
  • Pituitary adenoma with extrasellar extension
  • Pituitary cyst
  • Pituitary dermoid and epidermoid cysts
  • Pituitary macroadenoma
  • Pituitary macroadenoma with extrasellar extension
  • Pituitary mesoadenoma
  • Pituitary microadenoma
  • Prolactinoma
  • Secondary hyperprolactinemia
  • Secondary hyperprolactinemia due to prolactin-secreting tumor
  • Somatomammotropinoma
  • Somatotroph adenoma
  • Spindle cell oncocytoma of posterior pituitary gland
  • Suprasellar extension of pituitary adenoma
  • Thyrotoxicosis due to inappropriate TSH secretion
  • Thyrotoxicosis due to TSHoma
  • Thyrotroph adenoma
  • Thyrotropin overproduction

Clinical Classification

Clinical Information

  • Empty Sella Syndrome

    a condition when the sella turcica is not filled with pituitary tissue. the pituitary gland is either compressed, atrophied, or removed. there are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of pituitary neoplasms.
  • Sella Turcica

    a bony prominence situated on the upper surface of the body of the sphenoid bone. it houses the pituitary gland.
  • Prolactinoma

    a pituitary adenoma which secretes prolactin, leading to hyperprolactinemia. clinical manifestations include amenorrhea; galactorrhea; impotence; headache; visual disturbances; and cerebrospinal fluid rhinorrhea.
  • Granular Cell Tumor

    unusual tumor affecting any site of the body, but most often encountered in the head and neck. considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. it affects women more often than men. when it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D35.2 to ICD-9-CM

  • ICD-9-CM Code: 227.3 - Benign neo pituitary
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Table of Neoplasms

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
CaInSitu Benign Uncertain
»Neoplasm, neoplastic
  »craniobuccal pouch
»Neoplasm, neoplastic
  »fossa (of)
»Neoplasm, neoplastic
»Neoplasm, neoplastic
»Neoplasm, neoplastic
  »pituitary (body) (fossa) (gland) (lobe)
»Neoplasm, neoplastic
  »Rathke's pouch
»Neoplasm, neoplastic
  »sella turcica

Patient Education

Benign Tumors

Tumors are abnormal growths in your body. They can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Benign tumors grow only in one place. They cannot spread or invade other parts of your body. Even so, they can be dangerous if they press on vital organs, such as your brain.

Tumors are made up of extra cells. Normally, cells grow and divide to form new cells as your body needs them. When cells grow old, they die, and new cells take their place. Sometimes, this process goes wrong. New cells form when your body does not need them, and old cells do not die when they should. These extra cells can divide without stopping and may form tumor.

Treatment often involves surgery. Benign tumors usually don't grow back.

NIH: National Cancer Institute

[Learn More in MedlinePlus]

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.

[Learn More in MedlinePlus]


Overview of prolactinoma, a disorder in which a noncancerous tumor of the pituitary gland produces too much of the hormone prolactin.
[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.