2026 ICD-10-CM Diagnosis Code C49.3Malignant neoplasm of connective and soft tissue of thorax
ICD-10-CM Codes›C00–D49›C45-C49›C49
- Billable — Valid for Submission
- Chronic Condition
C49.3 is a billable ICD-10-CM diagnosis code for malignant neoplasm of connective and soft tissue of thorax. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 542 through 544. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sarcoma.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Leiomyosarcoma of esophagus
- Leiomyosarcoma of lower esophagus
- Malignant mesenchymal neoplasm of esophagus
- Malignant neoplasm of soft tissue of axilla
- Malignant neoplasm of soft tissue of thorax
- Neoplasm of blood vessel of axilla
- Neoplasm of blood vessel of shoulder
- Neoplasm of blood vessel of thorax
- Neoplasm of diaphragm
- Neoplasm of great vessels
- Neoplasm of muscle of abdomen
- Neoplasm of muscle of thorax
- Primary angiosarcoma of axillary region
- Primary angiosarcoma of shoulder region
- Primary angiosarcoma of thorax
- Primary angiosarcoma of trunk
- Primary leiomyosarcoma of thorax
- Primary liposarcoma of soft tissue of axilla
- Primary liposarcoma of soft tissue of limb
- Primary liposarcoma of soft tissue of thorax
- Primary liposarcoma of soft tissue of trunk
- Primary malignant fibrous histiocytoma of thorax
- Primary malignant neoplasm of axilla
- Primary malignant neoplasm of blood vessel of axilla
- Primary malignant neoplasm of blood vessel of shoulder
- Primary malignant neoplasm of blood vessel of thorax
- Primary malignant neoplasm of blood vessel of trunk
- Primary malignant neoplasm of blood vessel of upper limb
- Primary malignant neoplasm of diaphragm
- Primary malignant neoplasm of great vessels
- Primary malignant neoplasm of muscle of abdomen
- Primary malignant neoplasm of muscle of thorax
- Primary malignant neoplasm of muscle of trunk
- Primary malignant neoplasm of soft tissues of axilla
- Primary malignant neoplasm of soft tissues of thorax
- Primary rhabdomyosarcoma of axilla
- Primary rhabdomyosarcoma of shoulder region
- Primary rhabdomyosarcoma of thorax
- Primary sarcoma of axilla
- Primary sarcoma of thorax
- SMARCA4-deficient undifferentiated neoplasm of thorax
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Malignant neoplasm of axilla
- Malignant neoplasm of diaphragm
- Malignant neoplasm of great vessels
Type 1 Excludes
- malignant neoplasm of breast C50
- malignant neoplasm of heart C38.0
- malignant neoplasm of mediastinum C38.1 C38.3
- malignant neoplasm of thymus C37
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Contraceptive Devices, Female
contraceptive devices used by females.Diaphragm
the musculofibrous partition that separates the thoracic cavity from the abdominal cavity. contraction of the diaphragm increases the volume of the thoracic cavity aiding inhalation.Diaphragmatic Eventration
a congenital abnormality characterized by the elevation of the diaphragm dome. it is the result of a thinned diaphragmatic muscle and injured phrenic nerve, allowing the intra-abdominal viscera to push the diaphragm upward against the lung.Hernia, Diaphragmatic
protrusion of abdominal structures into the thorax as a result of congenital or traumatic defects in the respiratory diaphragm.Hernia, Diaphragmatic, Traumatic
the type of diaphragmatic hernia caused by trauma or injury, usually to the abdomen.Hernias, Diaphragmatic, Congenital
protrusion of abdominal structures into the thorax as a result of embryologic defects in the diaphragm often present in the neonatal period. it can be isolated, syndromic, non-syndromic or be a part of chromosome abnormality. associated pulmonary hypoplasia and pulmonary hypertension can further complicate stabilization and surgical intervention.Inferior Wall Myocardial Infarction
myocardial infarction in which the inferior wall of the heart is involved. it is often caused by occlusion of the right coronary artery.Pelvic Floor
soft tissue formed mainly by the pelvic diaphragm, which is composed of the two levator ani and two coccygeus muscles. the pelvic diaphragm lies just below the pelvic aperture (outlet) and separates the pelvic cavity from the perineum. it extends between the pubic bone anteriorly and the coccyx posteriorly.Peritoneal Stomata
natural openings in the subdiaphragmatic lymphatic plexus in the peritoneum, delimited by adjacent mesothelial cells. peritoneal stomata constitute the principal pathways for the drainage of intraperitoneal contents from the peritoneal cavity to the lymphatic system.Respiratory Paralysis
complete or severe weakness of the muscles of respiration. this condition may be associated with motor neuron diseases; peripheral nerve diseases; neuromuscular junction diseases; spinal cord diseases; injury to the phrenic nerve; and other disorders.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| aorta (thoracic) | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › axilla | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › chest (wall) | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › diaphragm | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › great vessels NEC | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › infraclavicular region | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › intrathoracic | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › scapular region | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › thoracic (duct) (wall) | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| connective tissue NEC › thorax | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| diaphragm | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| great vessels NEC | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| thorax, thoracic (cavity) (organs NEC) › duct | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
| vena cava (abdominal) (inferior) › superior | C49.3 | C79.89 | – | D21.3 | D48.1 | D49.2 |
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Convert C49.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C49.3Overview
Is C49.3 (Malignant neoplasm of other connective and soft tissue) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of connective and soft tissue of thorax on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does C49.3 group to?
When malignant neoplasm of connective and soft tissue of thorax is the principal diagnosis on an inpatient stay, it groups to MS-DRG 542, 543, 544, with relative weights from 0.7546 to 1.7665 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of C49.3?
Under the General Equivalence Mappings, malignant neoplasm of connective and soft tissue of thorax converts to ICD-9-CM 171.4 (mal neo soft tis thorax). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
