2026 ICD-10-CM Diagnosis Code C22.8Malignant neoplasm of liver, primary, unspecified as to type

ICD-10-CM Codes›C00–D49›C15-C26›C22

ICD-10-CM C22.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C22.8 is a billable ICD-10-CM diagnosis code for malignant neoplasm of liver, primary, unspecified as to type. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 435 through 437. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Gastrointestinal cancers - liver.

Code Identity

ICD-10-CM Code
C22.8
Billable Status
Yes — Valid for Submission
Code Describes
Malignant neoplasm of liver, primary, unspecified as to type
Short Description
Malignant neoplasm of liver, primary, unspecified as to type
Same as the full description in the CMS dataset.
Parent Code
C22
Malignant neoplasm of liver and intrahepatic bile ducts

Code Classification

ChapterC00–D49Neoplasms
SectionC15-C26Malignant neoplasms of digestive organs
CategoryC22Malignant neoplasm of liver and intrahepatic bile ducts
This CodeC22.8Malignant neoplasm of liver, primary, unspecified as to type

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Carcinoma liver and/or biliary system
  • Embryonal carcinoma
  • Epithelioid hemangioendothelioma
  • Epithelioid hemangioendothelioma of liver
  • Primary carcinoma liver and/or biliary system
  • Primary carcinoma of liver
  • Primary embryonal carcinoma of liver
  • Primary epithelioid hemangioendothelioma
  • Primary epithelioid hemangioendothelioma of liver
  • Primary malignant neoplasm of blood vessel of trunk
  • Primary malignant neoplasm of liver
  • Primary undifferentiated carcinoma of liver and intrahepatic biliary tract
  • Squamous cell carcinoma of liver and intrahepatic biliary tract
  • Undifferentiated carcinoma of liver and intrahepatic biliary tract

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO017
Gastrointestinal cancers - liver
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
hepatic [See Also: Index to disease, by histology] › primaryC22.8C78.7D01.5D13.4D37.6D49.0
liver [See Also: Index to disease, by histology] › primaryC22.8C78.7D01.5D13.4D37.6D49.0

Patient EducationClinical

Liver Cancer

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

The full article covers:

  • What is Liver Cancer?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert C22.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
155.0 Mal neo liver, primary
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C22.8Overview

Is C22.8 (Malignant neoplasm of liver and intrahepatic bile ducts) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of liver, primary, unspecified as to type on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C22.8 group to?

When malignant neoplasm of liver, primary, unspecified as to type is the principal diagnosis on an inpatient stay, it groups to MS-DRG 435, 436, 437, with relative weights from 0.8533 to 1.8367 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C22.8?

Under the General Equivalence Mappings, malignant neoplasm of liver, primary, unspecified as to type converts to ICD-9-CM 155.0 (mal neo liver, primary). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.