2027 ICD-10-CM Diagnosis Code C25Malignant neoplasm of pancreas

ICD-10-CM Codes›C00–D49›C15-C26›C25

ICD-10-CM C25
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

C25 is a non-billable ICD-10-CM category code for malignant neoplasm of pancreas, so it cannot be submitted on claims. Use a more specific code from this category instead, such as C25.0, C25.1, C25.2, and C25.3.

Code Identity

ICD-10-CM Code
C25
Billable Status
No — Non-Billable Category
Code Describes
Malignant neoplasm of pancreas
Short Description
Malignant neoplasm of pancreas
Same as the full description in the CMS dataset.
Chapter
C15-C26
Malignant neoplasms of digestive organs

Code Classification

ChapterC00–D49Neoplasms
SectionC15-C26Malignant neoplasms of digestive organs
CategoryC25Malignant neoplasm of pancreas
This CodeC25Malignant neoplasm of pancreas

Specific Coding for Malignant neoplasm of pancreasOverview

Non-specific codes like C25 require more characters. Use one of these billable codes instead:

  • Use C25.0 for Malignant neoplasm of head of pancreas

  • Use C25.1 for Malignant neoplasm of body of pancreas

  • Use C25.2 for Malignant neoplasm of tail of pancreas

  • Use C25.3 for Malignant neoplasm of pancreatic duct

  • Use C25.4 for Malignant neoplasm of endocrine pancreas

  • Use C25.7 for Malignant neoplasm of other parts of pancreas

  • Use C25.8 for Malignant neoplasm of overlapping sites of pancreas

  • Use C25.9 for Malignant neoplasm of pancreas, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to C25: its own notes plus those printed at block C15-C26 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block C15-C26 Malignant neoplasms of digestive organs applies to 60 codes
  • Kaposi's sarcoma of gastrointestinal sites (C46.4)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block C15-C26 Malignant neoplasms of digestive organs applies to 60 codes
  • gastrointestinal stromal tumors (C49.A-)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code to identify:
  • alcohol abuse and dependence (F10.-)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

  • if applicable exocrine pancreatic insufficiency (K86.81)

Notes

General instructions on how these codes are used.

From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name C25, its category, or a range that includes it.

Applicable To 2

These notes mention C25.

  • Z85.07 Personal history of malignant neoplasm of pancreas
    Conditions classifiable to C25
  • Z80.0 Family history of malignant neoplasm of digestive organs
    Conditions classifiable to C15-C26 names C15-C26, which includes this code

Clinical InformationClinical

  • Malignant Pancreatic Neoplasm

    a primary or metastatic malignant neoplasm that affects the pancreas.

Patient EducationClinical

Pancreatic Cancer

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About C25Overview

What is the ICD-10 code for malignant neoplasm of pancreas?

C25 is the ICD-10-CM category for malignant neoplasm of pancreas, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is C25 (Malignant neoplasm of pancreas) a billable code?

No. This is a category header that groups the codes for malignant neoplasm of pancreas, and headers cannot be submitted on claims. Claims for malignant neoplasm of pancreas need a more specific code from this category, such as C25.0, C25.1, and C25.2.

Can C25 be reported with C46.4?

Not as a rule. The Excludes1 note at block C15-C26, which applies to C25, lists "Kaposi's sarcoma of gastrointestinal sites (C46.4)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does C25 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code to identify: alcohol abuse and dependence (F10.-). The additional code is reported after C25.