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  6. 2024 ICD-10-CM Code C22
Version 2024
Non-Billable Code

2024 ICD-10-CM Diagnosis Code C22

Malignant neoplasm of liver and intrahepatic bile ducts

ICD-10-CM Code:
C22
ICD-10 Code for:
Malignant neoplasm of liver and intrahepatic bile ducts
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Neoplasms
    (C00–D49)
    • Malignant neoplasms of digestive organs
      (C15-C26)
      • Malignant neoplasm of liver and intrahepatic bile ducts
        (C22)

C22 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of malignant neoplasm of liver and intrahepatic bile ducts. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Malignant neoplasm of liver and intrahepatic bile ducts

Non-specific codes like C22 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for malignant neoplasm of liver and intrahepatic bile ducts:

  • Use C22.0 for Liver cell carcinoma - BILLABLE CODE

  • Use C22.1 for Intrahepatic bile duct carcinoma - BILLABLE CODE

  • Use C22.2 for Hepatoblastoma - BILLABLE CODE

  • Use C22.3 for Angiosarcoma of liver - BILLABLE CODE

  • Use C22.4 for Other sarcomas of liver - BILLABLE CODE

  • Use C22.7 for Other specified carcinomas of liver - BILLABLE CODE

  • Use C22.8 for Malignant neoplasm of liver, primary, unspecified as to type - BILLABLE CODE

  • Use C22.9 for Malignant neoplasm of liver, not specified as primary or secondary - BILLABLE CODE

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • malignant neoplasm of biliary tract NOS C24.9
  • secondary malignant neoplasm of liver and intrahepatic bile duct C78.7

Patient Education


Bile Duct Cancer

Your liver makes a digestive juice called bile. Your gallbladder stores it between meals. When you eat, your gallbladder pushes the bile into tubes called bile ducts. They carry the bile to your small intestine. The bile helps break down fat. It also helps the liver get rid of toxins and wastes.

Bile duct cancer is rare. It can happen in the parts of the bile ducts that are outside or inside the liver. Cancer of the bile duct outside of the liver is much more common. Risk factors include having inflammation of the bile duct, ulcerative colitis, and some liver diseases.

Symptoms can include:

  • Jaundice
  • Itchy skin
  • Fever
  • Abdominal pain

Tests to diagnose bile duct cancer may include a physical exam, imaging tests of the liver and bile ducts, blood tests, and a biopsy.

Treatments include surgery, radiation therapy, and chemotherapy.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Liver Cancer

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

Risk factors for primary liver cancer include :

  • Having hepatitis B or C
  • Heavy alcohol use
  • Having cirrhosis, or scarring of the liver
  • Having hemochromatosis, an iron storage disease
  • Obesity and diabetes

Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

What is Bile Duct Cancer (Cholangiocarcinoma)?

Learn about bile duct cancer (cholangiocarcinoma) risk factors, symptoms, tests to diagnose, factors affecting prognosis, staging, and treatment.
[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.