ICD-10-CM Code First Notes · Chapter 3 · FY 2027 D50-D89

Code First Notes in Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ICD-10-CM

A Code First note means the underlying condition named in the note is sequenced before this code. In Chapter 3 (D50-D89), notes printed in the chapter name other codes 30 times, and Code First Notes anywhere in the Tabular List name the chapter’s codes 27 times, covering 20 distinct codes, categories and ranges. Switch views to read the list either way.

✓ From the official FY 2027 ICD-10-CM Tabular ListDefinitions follow the Official Guidelines, Section I.A
30
References in Its Notes
27
References to Its Codes
20
Chapter Codes Named
D50-D89
Chapter 3
Chapter 3

Code First Notes by the code that carries the note

13 of 13 shown
  • D59.39 Other hemolytic-uremic syndrome
    • COVID-19 (U07.1)
    • complications of kidney transplant (T86.1-)
    • complications of heart transplant (T86.2-)
    • complications of liver transplant (T86.4-)
  • D61.2 Aplastic anemia due to other external agents
    • , if applicable, toxic effects of substances chiefly nonmedicinal as to source (T51-T65)
  • D63.0 Anemia in neoplastic disease
  • D63.1 Anemia in chronic kidney disease
    • underlying chronic kidney disease (CKD) (N18.-)
  • D63.8 Anemia in other chronic diseases classified elsewhere
  • D64.2 Secondary sideroblastic anemia due to drugs and toxins
    • poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)
  • D69.42 Congenital and hereditary thrombocytopenia purpura
    • thrombocytopenia with absent radius (TAR syndrome) (Q87.2)
  • D72.18 Eosinophilia in diseases classified elsewhere
    • chronic myelomonocytic leukemia (C93.1-)
  • D75.81 Myelofibrosis
    • malignant neoplasm of breast (C50.-)
  • D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
  • D84.81 Immunodeficiency due to conditions classified elsewhere
    • chromosomal abnormalities (Q90-Q99)
    • diabetes mellitus (E08-E13)
    • malignant neoplasms (C00-C96)
  • D89.81 Graft-versus-host disease applies to 4 codes
    • complications of transplanted organs and tissue (T86.-)
    • complications of blood transfusion (T80.89)
  • D89.83 Cytokine release syndrome applies to 6 codes
    • complications following infusion, transfusion and therapeutic injection (T80.89-)
    • complications of transplanted organs and tissue (T86.-)

The first view lists notes printed in this chapter (a note on a category or block applies to every code beneath it). The second lists codes of this chapter named by Code First Notes anywhere in the Tabular List, including notes in other chapters.

Questions About Code First Notes

What does a Code First note mean?

A Code First note means the underlying condition named in the note is sequenced before the code that carries the note. Under the etiology/manifestation convention, a “code first” note appears at the manifestation code and a “use additional code” note at the etiology code (Section I.A.13). The FY 2027 Tabular List has 810 of them; 600 name other codes, with 736 references to 429 distinct codes, categories and ranges.

Can a code with a Code First note be the principal diagnosis?

Not when it is a manifestation code. Codes titled “in diseases classified elsewhere” are never permitted as the first-listed or principal diagnosis; they must follow the underlying condition. The etiology and manifestation page lists them all.

Related References

ICD-10-CM Official GuidelinesICD-10-CM Code LookupICD-10-CM Codes ListCode Lists by Tag

Source: FY 2027 ICD-10-CM Tabular List (CMS and NCHS) and the ICD-10-CM Official Guidelines for Coding and Reporting FY 2027, Section I.A. ICD List is not affiliated with CMS or NCHS.