2027 ICD-10-CM Diagnosis Code Z79.818Long term (current) use of other agents affecting estrogen receptors and estrogen levels

ICD-10-CM Codes›Z00–Z99›Z77-Z99›current

ICD-10-CM Z79.818
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Z79.818 is a billable ICD-10-CM diagnosis code for long term (current) use of other agents affecting estrogen receptors and estrogen levels. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as long-term current use of leuprorelin. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.

Code Identity

ICD-10-CM Code
Z79.818
Billable Status
Yes — Valid for Submission
Code Describes
Long term (current) use of other agents affecting estrogen receptors and estrogen levels
Short Description
Lng trm (crnt) use of agnt aff estrog recpt & estrog levels
Parent Code
Z79.81
Long term (current) use of agents affecting estrogen receptors and estrogen levels

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategorycurrentLong term drug therapy (Z79)
This CodeZ79.818Long term (current) use of other agents affecting estrogen receptors and estrogen levels

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z79.818.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z79.818 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Long-term current use of leuprorelin

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Z79.818: its own notes plus those printed at Z79.81, Z79, block Z77-Z99, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Z79 Long term (current) drug therapy applies to 32 codes
  • long term (current) drug use for prophylactic purposes

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Long term (current) use of estrogen receptor downregulators
  • Long term (current) use of fulvestrant (Faslodex)
  • Long term (current) use of gonadotropin-releasing hormone (GnRH) agonist
  • Long term (current) use of goserelin acetate (Zoladex)
  • Long term (current) use of leuprolide acetate (leuprorelin) (Lupron)
  • Long term (current) use of megestrol acetate (Megace)

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Z79.81 Long term (current) use of agents affecting estrogen receptors and estrogen levels applies to 3 codes
  • hormone replacement therapy (Z79.890)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Z79 Long term (current) drug therapy applies to 32 codes
  • drug abuse and dependence (F11-F19)
  • drug use complicating pregnancy, childbirth, and the puerperium (O99.32-)

Code First

The underlying condition named in the note is sequenced before this code.

From Z79.81 Long term (current) use of agents affecting estrogen receptors and estrogen levels applies to 3 codes
  • if applicable:
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of prostate (C61)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Z79.81 Long term (current) use of agents affecting estrogen receptors and estrogen levels applies to 3 codes
  • code, if applicable, to identify:
  • estrogen receptor positive status (Z17.0)
  • family history of breast cancer (Z80.3)
  • genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)
  • personal history of breast cancer (Z85.3)
  • personal history of prostate cancer (Z85.46)
  • postmenopausal status (Z78.0)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

From Z79 Long term (current) drug therapy applies to 32 codes
  • any therapeutic drug level monitoring (Z51.81)
From Block Z77-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status applies to 567 codes
  • any follow-up examination (Z08-Z09)

Notes

General instructions on how these codes are used.

From Chapter 21 (Z00-Z99) Factors influencing health status and contact with health services applies to 1,425 codes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Z79.818, its category, or a range that includes it.

Excludes2 2

These codes carry an Excludes2 note naming Z79.818: its condition is not part of those codes, and both may be reported when the patient has both.

  • Z79.6 Long term (current) use of immunomodulators and immunosuppressants
    long term (current) use of agents affecting estrogen receptors and estrogen levels (Z79.81-) names Z79.81-, which includes this code
  • Z92.2 Personal history of drug therapy
    long term (current) drug therapy (Z79.-) names Z79.-, which includes this code

Code Also 1

These codes say Z79.818 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • Z51.81 Encounter for therapeutic drug level monitoring
    any long-term (current) drug therapy (Z79.-) names Z79.-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC025
Other specified status
Default principal diagnosis: inpatient No · outpatient Yes

Patient EducationClinical

Hormones

Hormones are your body's chemical messengers. They travel in your bloodstream to tissues or organs. They work slowly, over time, and affect many different processes, including:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z79.818 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V07.59 Use oth agnt af estrogen
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Z79.818Overview

Is Z79.818 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report long term (current) use of other agents affecting estrogen receptors and estrogen levels on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Z79.818 group to?

On inpatient claims, long term (current) use of other agents affecting estrogen receptors and estrogen levels maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.

Can Z79.818 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because long term (current) use of other agents affecting estrogen receptors and estrogen levels describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z79.818 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for long term (current) use of other agents affecting estrogen receptors and estrogen levels on inpatient claims. The code appears in the Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99) range of the CMS exempt list.

Can Z79.818 be reported with Z79.890?

Not as a rule. The Excludes1 note at Z79.81, which applies to Z79.818, lists "hormone replacement therapy (Z79.890)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).