2026 ICD-10-CM Diagnosis Code Z79.818Long term (current) use of other agents affecting estrogen receptors and estrogen levels

ICD-10-CM Codes›Z00–Z99›Z77-Z99›current

ICD-10-CM Z79.818
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z79.818 is a billable ICD-10-CM diagnosis code for long term (current) use of other agents affecting estrogen receptors and estrogen levels. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as long-term current use of leuprorelin. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.

Code Identity

ICD-10-CM Code
Z79.818
Billable Status
Yes — Valid for Submission
Code Describes
Long term (current) use of other agents affecting estrogen receptors and estrogen levels
Short Description
Lng trm (crnt) use of agnt aff estrog recpt & estrog levels
Parent Code
Z79.81
Long term (current) use of agents affecting estrogen receptors and estrogen levels

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategorycurrentLong term drug therapy (Z79)
This CodeZ79.818Long term (current) use of other agents affecting estrogen receptors and estrogen levels

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z79.818.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z79.818 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Long-term current use of leuprorelin

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Long term (current) use of estrogen receptor downregulators
  • Long term (current) use of fulvestrant (Faslodex)
  • Long term (current) use of gonadotropin-releasing hormone (GnRH) agonist
  • Long term (current) use of goserelin acetate (Zoladex)
  • Long term (current) use of leuprolide acetate (leuprorelin) (Lupron)
  • Long term (current) use of megestrol acetate (Megace)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Long-term(current) (prophylactic) drug therapy (use of)
      • agents affecting estrogen receptors and estrogen levels NEC
    • Long-term(current) (prophylactic) drug therapy (use of)
      • estrogen receptor downregulators
    • Long-term(current) (prophylactic) drug therapy (use of)
      • fulvestrant (Faslodex)
    • Long-term(current) (prophylactic) drug therapy (use of)
      • gonadotropin-releasing hormone (GnRH) agonist
    • Long-term(current) (prophylactic) drug therapy (use of)
      • goserelin acetate (Zoladex)
    • Long-term(current) (prophylactic) drug therapy (use of)
      • leuprolide acetate (leuprorelin) (Lupron)
    • Long-term(current) (prophylactic) drug therapy (use of)
      • megestrol acetate (Megace)
    • Therapy
      • drug, long-term (current) (prophylactic)
        • agents affecting estrogen receptors and estrogen levels NEC
    • Therapy
      • drug, long-term (current) (prophylactic)
        • estrogen receptor downregulators
    • Therapy
      • drug, long-term (current) (prophylactic)
        • fulvestrant (Faslodex)
    • Therapy
      • drug, long-term (current) (prophylactic)
        • gonadotropin-releasing hormone (GnRH) agonist
    • Therapy
      • drug, long-term (current) (prophylactic)
        • goserelin acetate (Zoladex)
    • Therapy
      • drug, long-term (current) (prophylactic)
        • leuprolide acetate (leuprorelin) (Lupron)
    • Therapy
      • drug, long-term (current) (prophylactic)
        • megestrol acetate (Megace)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC025
Other specified status
Default principal diagnosis: inpatient No · outpatient Yes

Convert Z79.818 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V07.59 Use oth agnt af estrogen
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z79.818Overview

Is Z79.818 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report long term (current) use of other agents affecting estrogen receptors and estrogen levels on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z79.818 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because long term (current) use of other agents affecting estrogen receptors and estrogen levels describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z79.818 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for long term (current) use of other agents affecting estrogen receptors and estrogen levels on inpatient claims.

What is the ICD-9 equivalent of Z79.818?

Under the General Equivalence Mappings, long term (current) use of other agents affecting estrogen receptors and estrogen levels converts to ICD-9-CM V07.59 (use oth agnt af estrogen). The mapping is a direct match.