Allergy status to drugs, medicaments and biological substances (Z88) ICD-10-CM
The Z88 code range covers allergy status to drugs, medicaments and biological substances with 11 ICD-10-CM diagnosis codes. 10 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- Allergy status, other than to drugs and biological substances Z91.0
Codes in the Z88 Range 11 codes · 10 billable
- Z88 Allergy status to drugs, medicaments and biological substancesNon-billable
- Z88.0 Allergy status to penicillin
- Z88.1 Allergy status to other antibiotic agents
- Z88.2 Allergy status to sulfonamides
- Z88.3 Allergy status to other anti-infective agents
- Z88.4 Allergy status to anesthetic agent
- Z88.5 Allergy status to narcotic agent
- Z88.6 Allergy status to analgesic agent
- Z88.7 Allergy status to serum and vaccine
- Z88.8 Allergy status to other drugs, medicaments and biological substances
- Z88.9 Allergy status to unspecified drugs, medicaments and biological substances
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the Z88 range.
Drug Tolerance
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
About the Z88 Code Range
ICD-10 codes in the Z88 category are used to document a patient’s past or current allergy status to various drugs, medicaments, and biological substances. These codes help identify specific drug allergies such as to penicillin (Z88.0), other antibiotics (Z88.1), sulfonamides (Z88.2), anesthetics (Z88.4), narcotics (Z88.5), analgesics (Z88.6), vaccines (Z88.7), and other drug classes (Z88.8), along with a general code for unspecified allergies (Z88.9).
The ICD-10 code for allergy status to penicillin (Z88.0) covers allergies to common penicillin forms such as amoxicillin and ampicillin. For allergies to a broader range of antibiotics like cephalosporins, macrolides, or fluoroquinolones, coders use Z88.1. Sulfonamide allergies, including reactions to sulfa drugs and related diuretics, are classified under Z88.2. If a patient has hypersensitivity to anesthetic agents like lidocaine or propofol, Z88.4 applies. Allergies to analgesics, including opioids and NSAIDs like ibuprofen, are coded with Z88.6. The section also captures vaccine-related allergies using Z88.7. For diverse or less common drug allergies, Z88.8 provides a comprehensive category covering a wide range of substances. When the drug allergy is known but unspecified, Z88.9 is used. Understanding this classification ensures accurate recording of allergy history crucial for safe patient care and treatment planning.
Questions About This Page
How many billable codes are in the Z88 range?
Of the 11 codes in this range, 10 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the Z88 range classify?
The range classifies allergy status to drugs, medicaments and biological substances. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
