Allergy status to drugs, medicaments and biological substances (Z88) ICD-10-CM
The Z88 code range covers allergy status to drugs, medicaments and biological substances with 11 ICD-10-CM diagnosis codes. 10 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- Allergy status, other than to drugs and biological substances Z91.0
Codes in the Z88 Range 11 codes · 10 billable
- Z88 Allergy status to drugs, medicaments and biological substancesNon-billable
- Z88.0 Allergy status to penicillin
- Z88.1 Allergy status to other antibiotic agents
- Z88.2 Allergy status to sulfonamides
- Z88.3 Allergy status to other anti-infective agents
- Z88.4 Allergy status to anesthetic agent
- Z88.5 Allergy status to narcotic agent
- Z88.6 Allergy status to analgesic agent
- Z88.7 Allergy status to serum and vaccine
- Z88.8 Allergy status to other drugs, medicaments and biological substances
- Z88.9 Allergy status to unspecified drugs, medicaments and biological substances
About the Z88 Code Range
These codes describe a person’s allergy status to a drug, medicine or biological substance. The subdivisions identify the substance involved.
Z88.0 identifies penicillin, while Z88.1 identifies other antibiotics. Z88.2 identifies sulfonamides, and Z88.3 identifies other anti-infective agents. Other subdivisions identify anesthetic agents, narcotic agents, pain-relieving agents, and serum or vaccines. Z88.8 identifies other drugs, medicines and biological substances; Z88.9 applies when the substance is unspecified.
Questions About This Page
How many billable codes are in the Z88 range?
Of the 11 codes in this range, 10 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the Z88 range classify?
The range classifies allergy status to drugs, medicaments and biological substances. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
