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  5. Allergy status to drugs, medicaments and biological substances (Z88)

Allergy status to drugs, medicaments and biological substances (Z88)

ICD-10 codes in the Z88 category are used to document a patient’s past or current allergy status to various drugs, medicaments, and biological substances. These codes help identify specific drug allergies such as to penicillin (Z88.0), other antibiotics (Z88.1), sulfonamides (Z88.2), anesthetics (Z88.4), narcotics (Z88.5), analgesics (Z88.6), vaccines (Z88.7), and other drug classes (Z88.8), along with a general code for unspecified allergies (Z88.9).

The ICD-10 code for allergy status to penicillin (Z88.0) covers allergies to common penicillin forms such as amoxicillin and ampicillin. For allergies to a broader range of antibiotics like cephalosporins, macrolides, or fluoroquinolones, coders use Z88.1. Sulfonamide allergies, including reactions to sulfa drugs and related diuretics, are classified under Z88.2. If a patient has hypersensitivity to anesthetic agents like lidocaine or propofol, Z88.4 applies. Allergies to analgesics, including opioids and NSAIDs like ibuprofen, are coded with Z88.6. The section also captures vaccine-related allergies using Z88.7. For diverse or less common drug allergies, Z88.8 provides a comprehensive category covering a wide range of substances. When the drug allergy is known but unspecified, Z88.9 is used. Understanding this classification ensures accurate recording of allergy history crucial for safe patient care and treatment planning.

Instructional Notations

Type 2 Excludes

A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

  • Allergy status, other than to drugs and biological substances Z91.0

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Drug Tolerance

Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.