2024 ICD-10-CM Diagnosis Code Z51.81

Encounter for therapeutic drug level monitoring

ICD-10-CM Code:
Z51.81
ICD-10 Code for:
Encounter for therapeutic drug level monitoring
Is Billable?
Yes - Valid for Submission
Code Navigator:

Code Classification

  • Factors influencing health status and contact with health services
    (Z00–Z99)
    • Encounters for other specific health care
      (Z40-Z53)
      • Encounter for other aftercare and medical care
        (Z51)

Z51.81 is a billable diagnosis code used to specify a medical diagnosis of encounter for therapeutic drug level monitoring. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acetaminophen above therapeutic range
  • Acetaminophen within therapeutic range
  • Aminophylline level - finding
  • Aminophylline level - finding
  • Aminophylline level - finding
  • Aminophylline: blood level - finding
  • Aminophylline: blood level - finding
  • Aminophylline: blood level - finding
  • Antihypertensive agent surveillance done
  • Asthma monitoring status
  • Attends hormone replacement monitoring
  • Bronchodilators used a maximum of once daily
  • Bronchodilators used more than once daily
  • Bronchodilators used once daily
  • Carbamazepine level - finding
  • Carbamazepine level - finding
  • Carbamazepine level - finding
  • Carbamazepine level above reference range
  • Carbamazepine level below reference range
  • Carbamazepine level therapeutic
  • Digoxin level - finding
  • Digoxin level - finding
  • Digoxin level - finding
  • Digoxin level above therapeutic range
  • Digoxin level below therapeutic range
  • Digoxin level therapeutic
  • Drug action decreased
  • Drug action increased
  • Drug action prolonged
  • Drug action reversal
  • Drug action shortened
  • Effects of immunotherapy
  • Finding of serum phenobarbital level
  • Finding of serum phenobarbital level
  • Finding of serum phenobarbital level
  • Good response to medication
  • Gout monitoring status
  • Hormone replacement monitoring check done
  • Hormone replacement monitoring status
  • Hormone replacement monitoring status
  • Inhaler technique - moderate
  • Inhaler technique - poor
  • Intermittent drugs used more
  • Lack of drug action
  • Lithium level - finding
  • Lithium level - finding
  • Lithium level - finding
  • Lithium level below therapeutic range
  • Lithium level therapeutic
  • Lithium: blood level - finding
  • Lithium: blood level - finding
  • Lithium: blood level - finding
  • Measurement of medication level in blood started
  • Medication dose changed
  • Medication dose changed
  • Medication dose changed
  • Medication dose changed in response to liver function
  • Medication dose changed in response to renal function
  • Medication dose changed to sliding scale
  • Medication dose changed too rapidly
  • Medication monitoring up to date
  • Medication therapy changed too rapidly
  • Nebulizer technique good
  • Nebulizer technique poor
  • No nebulization since last appointment
  • PEM completed
  • Phenobarbitone level - finding
  • Phenobarbitone level - finding
  • Phenobarbitone level - finding
  • Phenobarbitone level above therapeutic range
  • Phenobarbitone level below therapeutic range
  • Phenobarbitone level therapeutic
  • Phenothiazine injection - monitor
  • Phenytoin level - finding
  • Phenytoin level - finding
  • Phenytoin level - finding
  • Phenytoin level above therapeutic range
  • Phenytoin level below reference range
  • Phenytoin level therapeutic
  • Prescription event monitoring status
  • Pre-treatment uric acid level
  • Salicylate above therapeutic range
  • Salicylate below therapeutic range
  • Serum aminophylline above therapeutic range
  • Serum aminophylline below therapeutic range
  • Serum aminophylline level - finding
  • Serum aminophylline level - finding
  • Serum aminophylline level - finding
  • Serum aminophylline within therapeutic range
  • Serum carbamazepine above therapeutic range
  • Serum carbamazepine below therapeutic range
  • Serum carbamazepine level - finding
  • Serum carbamazepine level - finding
  • Serum carbamazepine level - finding
  • Serum carbamazepine within therapeutic range
  • Serum digoxin level - finding
  • Serum digoxin level - finding
  • Serum digoxin level - finding
  • Serum digoxin level above therapeutic range
  • Serum digoxin level below therapeutic range
  • Serum digoxin level within therapeutic range
  • Serum lithium level - finding
  • Serum lithium level - finding
  • Serum lithium level - finding
  • Serum lithium level above therapeutic range
  • Serum lithium level below therapeutic range
  • Serum lithium level within therapeutic range
  • Serum phenobarbital above therapeutic range
  • Serum phenobarbital below therapeutic range
  • Serum phenobarbital within therapeutic range
  • Serum phenytoin above therapeutic range
  • Serum phenytoin below therapeutic range
  • Serum phenytoin level - finding
  • Serum phenytoin level - finding
  • Serum phenytoin level - finding
  • Serum phenytoin within therapeutic range
  • Serum sodium valproate above therapeutic range
  • Serum sodium valproate below therapeutic range
  • Serum sodium valproate level - finding
  • Serum sodium valproate level - finding
  • Serum sodium valproate level - finding
  • Serum sodium valproate within therapeutic range
  • Therapeutic drug effect
  • Valproate level - finding
  • Valproate level - finding
  • Valproate level - finding
  • Warfarin monitoring status

Clinical Classification

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Code Also

Code Also
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • any long-term current drug therapy Z79

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • encounter for blood-drug test for administrative or medicolegal reasons Z02.83

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Present on Admission (POA)

Z51.81 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA IndicatorReason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert Z51.81 to ICD-9-CM

  • ICD-9-CM Code: V58.83 - Therapeutic drug monitor

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.