2026 ICD-10-CM Diagnosis Code Z15.89Genetic susceptibility to other disease

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15.89
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z15.89 is a billable ICD-10-CM diagnosis code for genetic susceptibility to other disease. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genetic susceptibility to disease.

Code Identity

ICD-10-CM Code
Z15.89
Billable Status
Yes — Valid for Submission
Code Describes
Genetic susceptibility to other disease
Short Description
Genetic susceptibility to other disease
Same as the full description in the CMS dataset.
Parent Code
Z15.8
Genetic susceptibility to other disease

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15.89Genetic susceptibility to other disease

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z15.89.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z15.89 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 1 deficiency
  • Autosomal dominant mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to complete RORgamma receptor mutation
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial interferon gamma receptor 2 deficiency
  • Autosomal recessive mendelian susceptibility to mycobacterial disease due to partial JAK1 deficiency
  • Dense body defect
  • Familial platelet syndrome with predisposition to acute myelogenous leukemia
  • Genetic susceptibility to cardiovascular disorder
  • Genetic susceptibility to genetic disorder
  • Genetic susceptibility to malignant hyperthermia due to calcium voltage-gated channel subunit alpha1 S gene mutation
  • Genetic susceptibility to malignant hyperthermia due to ryanodine receptor 1 gene mutation
  • Malignant hyperthermia genetic susceptibility
  • Mendelian susceptibility to mycobacterial disease
  • Mendelian susceptibility to mycobacterial disease due to complete IL12RB1 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 1 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interferon gamma receptor 2 deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete interleukin 12 subunit beta deficiency
  • Mendelian susceptibility to mycobacterial disease due to complete ISG15 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial IRF8 deficiency
  • Mendelian susceptibility to mycobacterial disease due to partial STAT1 deficiency
  • Predisposition to invasive fungal disease due to CARD9 deficiency
  • Predisposition to severe viral infection due to IRF7 deficiency
  • Susceptibility to infection due to TYK2 deficiency
  • Uncertain genetic susceptibility to malignant hyperthermia due to CACNA1S gene mutation
  • Uncertain malignant hyperthermia predisposition due to RyR1 gene mutation
  • X-linked mendelian susceptibility to mycobacterial disease

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Genetic
      • susceptibility to disease NEC
    • Susceptibility to disease, genetic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC029
Genetic susceptibility to disease
Default principal diagnosis: inpatient No · outpatient No

Convert Z15.89 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V84.89 Genetic suscept dis NEC
Exact Match The mapping is direct, with no qualifiers.

Code History & ChangesHistory

Replaced This code was replaced in the FY 2026 code set by:

  • Z15.3 - Genetic susceptibility to kidney disease
FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z15.89Overview

Is Z15.89 (Genetic susceptibility to other disease) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report genetic susceptibility to other disease on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z15.89 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because genetic susceptibility to other disease describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z15.89 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for genetic susceptibility to other disease on inpatient claims.

What is the ICD-9 equivalent of Z15.89?

Under the General Equivalence Mappings, genetic susceptibility to other disease converts to ICD-9-CM V84.89 (genetic suscept dis NEC). The mapping is a direct match.