2026 ICD-10-CM Diagnosis Code T88.6XXSAnaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela
T88.6XXS is a billable ICD-10-CM diagnosis code for anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T88.6XXS is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to platelet aggregation inhibitor
- Adverse reaction to salicylate
- Adverse reaction to whole blood
- Allergic reaction after allergen immunotherapy
- Allergic reaction caused by analgesic
- Allergic reaction caused by anesthetic
- Allergic reaction caused by antibacterial agent
- Allergic reaction caused by antiinfective agent
- Allergic reaction caused by nonsteroidal antiinflammatory agent
- Allergic reaction caused by penicillin
- Allergic reaction caused by sulfonamide
- Allergic reaction to radiocontrast media
- Anaphylaxis after allergen immunotherapy
- Anaphylaxis caused by allergy skin test
- Anaphylaxis caused by analgesic
- Anaphylaxis caused by anesthetic
- Anaphylaxis caused by antibacterial agent
- Anaphylaxis caused by non-steroidal anti-inflammatory agent
- Anaphylaxis caused by radiographic contrast media
- Anaphylaxis caused by sulfonamide
- Aspirin adverse reaction
- Blood product-induced anaphylactoid reaction
- Contrast media adverse reaction
- Drug-induced anaphylaxis
- Immediate transfusion reaction
- Non-allergic anaphylaxis caused by aspirin
- Non-allergic anaphylaxis caused by drug
- Non-allergic anaphylaxis caused by non steroidal anti-inflammatory drug
- Non-allergic anaphylaxis caused by parasympathomimetic agent
- Non-allergic anaphylaxis caused by whole blood
- Non-allergic hypersensitivity reaction caused by dialysis membrane
- Non-allergic hypersensitivity reaction caused by radiocontrast media
- Non-allergic hypersensitivity reaction during dialysis
- Penicillin-induced anaphylaxis
Coding GuidelinesGuidance
The appropriate 7th character is to be added to each code from block Other complications of surgical and medical care, not elsewhere classified (T88). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Anaphylaxis
Anaphylaxis is a serious allergic reaction. It can begin very quickly, and symptoms may be life-threatening. The most common causes are reactions to foods (especially peanuts), medications, and stinging insects. Other causes include exercise and exposure to latex. Sometimes no cause can be found.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T88.6XXS to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T88.6XXSOverview
Is T88.6XXS a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T88.6XXS mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the anaphylactic reaction due to adverse effect of correct drug or medicament properly administered itself has resolved, not the original event.
What MS-DRG does T88.6XXS group to?
When anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T88.6XXS exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela on inpatient claims.
What is the ICD-9 equivalent of T88.6XXS?
Under the General Equivalence Mappings, anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela converts to ICD-9-CM 909.5 (lte efct advrs efct drug). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
