2027 ICD-10-CM Diagnosis Code T80.51XSAnaphylactic reaction due to administration of blood and blood products, sequela

ICD-10-CM Codes›S00–T88›T80-T88›T80

ICD-10-CM T80.51XS
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T80.51XS is a billable ICD-10-CM diagnosis code for anaphylactic reaction due to administration of blood and blood products, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. Coders also document this condition as anaphylactic transfusion reaction. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication, sequela.

Code Identity

ICD-10-CM Code
T80.51XS
Billable Status
Yes — Valid for Submission
Code Describes
Anaphylactic reaction due to administration of blood and blood products, sequela
Short Description
Anaphylactic reaction due to admin blood/products, sequela
Parent Code
T80.51
Anaphylactic reaction due to administration of blood and blood products

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT80-T88Complications of surgical and medical care, not elsewhere classified
CategoryT80Complications following infusion, transfusion and therapeutic injection
This CodeT80.51XSAnaphylactic reaction due to administration of blood and blood products, sequela

Present on Admission (POA)Billing

T80.51XS is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Complications of surgical and medical care, not elsewhere classified (T80-T88).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Anaphylactic transfusion reaction
  • Blood product-induced anaphylactoid reaction
  • Immediate transfusion reaction
  • Non-allergic anaphylaxis caused by immunoglobulin

Coding GuidelinesGuidance

The appropriate 7th character is to be added to each code from block Complications following infusion, transfusion and therapeutic injection (T80). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T80.51XS: its own notes plus those printed at T80.5, T80, block T80-T88, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From T80 Complications following infusion, transfusion and therapeutic injection applies to 114 codes
  • complications following perfusion

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From T80.5 Anaphylactic reaction due to serum applies to 9 codes
  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From T80 Complications following infusion, transfusion and therapeutic injection applies to 114 codes
  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)
From Block T80-T88 Complications of surgical and medical care, not elsewhere classified applies to 1,683 codes
  • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
  • artificial opening status (Z93.-)
  • closure of external stoma (Z43.-)
  • fitting and adjustment of external prosthetic device (Z44.-)
  • burns and corrosions from local applications and irradiation (T20-T32)
  • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
  • mechanical complication of respirator [ventilator] (J95.850)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
  • postprocedural fever (R50.82)
  • specified complications classified elsewhere, such as:
  • cerebrospinal fluid leak from spinal puncture (G97.0)
  • colostomy malfunction (K94.0-)
  • disorders of fluid and electrolyte imbalance (E86-E87)
  • functional disturbances following cardiac surgery (I97.0-I97.1)
  • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
  • ostomy complications (J95.0-, K94.-, N99.5-)
  • postgastric surgery syndromes (K91.1)
  • postlaminectomy syndrome NEC (M96.1)
  • postmastectomy lymphedema syndrome (I97.2)
  • postsurgical blind-loop syndrome (K91.2)
  • ventilator associated pneumonia (J95.851)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T80-T88 Complications of surgical and medical care, not elsewhere classified applies to 1,683 codes
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • code(s) to identify the specified condition resulting from the complication
  • code to identify devices involved and details of circumstances (Y62-Y82)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T80 Complications following infusion, transfusion and therapeutic injection applies to 114 codes
  • The appropriate 7th character is to be added to each code from category T80
Values for category T80 Encounter: Initial, Subsequent, Sequela
  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela this code

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T80.51XS, its category, or a range that includes it.

Excludes1 5

These codes carry an Excludes1 note naming T80.51XS: they are not reported together with it, unless the two conditions are unrelated.

  • R57 Shock, not elsewhere classified
    anaphylactic shock due to serum (T80.5-) names T80.5-, which includes this code
  • T78.2 Anaphylactic shock, unspecified
    anaphylactic reaction or shock due to serum (T80.5-) names T80.5-, which includes this code
  • T79.4 Traumatic shock
    anaphylactic shock due to serum (T80.5-) names T80.5-, which includes this code
  • T81.1 Postprocedural shock
    anaphylactic shock due to serum (T80.5-) names T80.5-, which includes this code
  • T88.6 Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered
    anaphylactic reaction due to serum (T80.5-) names T80.5-, which includes this code

Excludes2 4

These codes carry an Excludes2 note naming T80.51XS: its condition is not part of those codes, and both may be reported when the patient has both.

  • T45.8 Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
    transfusion reactions (T80.-) names T80.-, which includes this code
  • T81 Complications of procedures, not elsewhere classified
    complications following infusion, transfusion and therapeutic injection (T80.-) names T80.-, which includes this code
  • T88 Other complications of surgical and medical care, not elsewhere classified
    complication following infusion, transfusion and therapeutic injection (T80.-) names T80.-, which includes this code
  • T88.1 Other complications following immunization, not elsewhere classified
    anaphylactic shock due to serum (T80.5-) names T80.5-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ076
Complication, sequela
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Anaphylaxis

Anaphylaxis is a serious allergic reaction. It can begin very quickly, and symptoms may be life-threatening. The most common causes are reactions to foods (especially peanuts), medications, and stinging insects. Other causes include exercise and exposure to latex. Sometimes no cause can be found.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T80.51XS to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
909.3 Late eff surg/med compl
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T80.51XSOverview

Is T80.51XS a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report anaphylactic reaction due to administration of blood and blood products, sequela on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character S in T80.51XS mean?

The final character S makes this a sequela code: it reports a lingering problem that remains after the anaphylactic reaction due to administration of blood and blood products itself has resolved, not the original event.

What MS-DRG does T80.51XS group to?

When anaphylactic reaction due to administration of blood and blood products, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 923, 922, with relative weights from 0.9980 to 1.6248 depending on complications. Higher weights mean higher Medicare reimbursement.

Is T80.51XS exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for anaphylactic reaction due to administration of blood and blood products, sequela on inpatient claims. The code appears in the Complications of surgical and medical care, not elsewhere classified (T80-T88) range of the CMS exempt list.

Can T80.51XS be reported with a code from T80.3?

Not as a rule. The Excludes1 note at T80.5, which applies to T80.51XS, lists "ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).