2027 ICD-10-CM Diagnosis Code T80.22XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter

ICD-10-CM Codes›S00–T88›T80-T88›T80

ICD-10-CM T80.22XA
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T80.22XA is a billable ICD-10-CM diagnosis code for acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 856 through 858, 867 through 869. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 10 closely related codes. Coders also document this condition as septic shock due to transfusion. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication of other surgical or medical care, injury, initial encounter.

Code Identity

ICD-10-CM Code
T80.22XA
Billable Status
Yes — Valid for Submission
Code Describes
Acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter
Short Description
Acute infct fol tranfs,infusn,inject blood/products, init
Parent Code
T80.22
Acute infection following transfusion, infusion, or injection of blood and blood products

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT80-T88Complications of surgical and medical care, not elsewhere classified
CategoryT80Complications following infusion, transfusion and therapeutic injection
This CodeT80.22XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Septic shock due to transfusion

Coding GuidelinesGuidance

The appropriate 7th character is to be added to each code from block Complications following infusion, transfusion and therapeutic injection (T80). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T80.22XA: its own notes plus those printed at T80.2, T80, block T80-T88, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From T80 Complications following infusion, transfusion and therapeutic injection applies to 114 codes
  • complications following perfusion

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From T80.2 Infections following infusion, transfusion and therapeutic injection applies to 18 codes
From T80 Complications following infusion, transfusion and therapeutic injection applies to 114 codes
  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)
From Block T80-T88 Complications of surgical and medical care, not elsewhere classified applies to 1,683 codes
  • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
  • artificial opening status (Z93.-)
  • closure of external stoma (Z43.-)
  • fitting and adjustment of external prosthetic device (Z44.-)
  • burns and corrosions from local applications and irradiation (T20-T32)
  • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
  • mechanical complication of respirator [ventilator] (J95.850)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
  • postprocedural fever (R50.82)
  • specified complications classified elsewhere, such as:
  • cerebrospinal fluid leak from spinal puncture (G97.0)
  • colostomy malfunction (K94.0-)
  • disorders of fluid and electrolyte imbalance (E86-E87)
  • functional disturbances following cardiac surgery (I97.0-I97.1)
  • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
  • ostomy complications (J95.0-, K94.-, N99.5-)
  • postgastric surgery syndromes (K91.1)
  • postlaminectomy syndrome NEC (M96.1)
  • postmastectomy lymphedema syndrome (I97.2)
  • postsurgical blind-loop syndrome (K91.2)
  • ventilator associated pneumonia (J95.851)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From T80.2 Infections following infusion, transfusion and therapeutic injection applies to 18 codes
  • code to identify the specific infection, such as:
  • sepsis (A41.9)
  • code (R65.2-) to identify severe sepsis, if applicable
From Block T80-T88 Complications of surgical and medical care, not elsewhere classified applies to 1,683 codes
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • code(s) to identify the specified condition resulting from the complication
  • code to identify devices involved and details of circumstances (Y62-Y82)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T80 Complications following infusion, transfusion and therapeutic injection applies to 114 codes
  • The appropriate 7th character is to be added to each code from category T80
Values for category T80 Encounter: Initial, Subsequent, Sequela
  • Ainitial encounter this code
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T80.22XA, its category, or a range that includes it.

Excludes2 4

These codes carry an Excludes2 note naming T80.22XA: its condition is not part of those codes, and both may be reported when the patient has both.

  • T45.8 Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
    transfusion reactions (T80.-) names T80.-, which includes this code
  • T81 Complications of procedures, not elsewhere classified
    complications following infusion, transfusion and therapeutic injection (T80.-) names T80.-, which includes this code
  • T81.4 Infection following a procedure
    infection due to infusion, transfusion and therapeutic injection (T80.2-) names T80.2-, which includes this code
  • T88 Other complications of surgical and medical care, not elsewhere classified
    complication following infusion, transfusion and therapeutic injection (T80.-) names T80.-, which includes this code

Code First 4

These codes say to code first a condition named in the note, and T80.22XA is one of the conditions named.

  • A40 Streptococcal sepsis
    streptococcal sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-) names T80.22-, which includes this code
  • A41 Other sepsis
    sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-) names T80.22-, which includes this code
  • A84.89 Other tick-borne viral encephalitis
    if applicable, transfusion related infection (T80.22-) names T80.22-, which includes this code
  • R65.2 Severe sepsis
    infections following infusion, transfusion and therapeutic injection (T80.2-) names T80.2-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ037
Complication of other surgical or medical care, injury, initial encounter
Default principal diagnosis: inpatient Yes · outpatient Yes

Convert T80.22XA to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
999.34 Ac inf fol trans,inf bld
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T80.22XAOverview

Is T80.22XA a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character A in T80.22XA mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for acute infection following transfusion, infusion, or injection of blood and blood products, such as an emergency visit or first evaluation.

What MS-DRG does T80.22XA group to?

When acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 858, 856, 857, 867, 869, 868, with relative weights from 0.6784 to 4.4822 depending on complications. Higher weights mean higher Medicare reimbursement.

Is T80.22XA a CC or MCC?

CMS lists T80.22XA as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 10 closely related codes in its exclusion list.

Does T80.22XA need an additional code?

When the condition applies, yes. The Use Additional Code note at T80.2, which applies to T80.22XA, reads: code to identify the specific infection, such as: sepsis (A41.9); code (R65.2-) to identify severe sepsis, if applicable. The additional code is reported after T80.22XA.