2026 ICD-10-CM Diagnosis Code T80.22XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter

ICD-10-CM Codes›S00–T88›T80-T88›T80

ICD-10-CM T80.22XA
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

T80.22XA is a billable ICD-10-CM diagnosis code for acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 856 through 858, 867 through 869. Coders also document this condition as septic shock due to transfusion. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication of other surgical or medical care, injury, initial encounter.

Code Identity

ICD-10-CM Code
T80.22XA
Billable Status
Yes — Valid for Submission
Code Describes
Acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter
Short Description
Acute infct fol tranfs,infusn,inject blood/products, init
Parent Code
T80.22
Acute infection following transfusion, infusion, or injection of blood and blood products

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT80-T88Complications of surgical and medical care, not elsewhere classified
CategoryT80Complications following infusion, transfusion and therapeutic injection
This CodeT80.22XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Septic shock due to transfusion

Coding GuidelinesGuidance

The appropriate 7th character is to be added to each code from block Complications following infusion, transfusion and therapeutic injection (T80). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ037
Complication of other surgical or medical care, injury, initial encounter
Default principal diagnosis: inpatient Yes · outpatient Yes

Convert T80.22XA to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
999.34 Ac inf fol trans,inf bld
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About T80.22XAOverview

Is T80.22XA a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What does the 7th character A in T80.22XA mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for acute infection following transfusion, infusion, or injection of blood and blood products, such as an emergency visit or first evaluation.

What MS-DRG does T80.22XA group to?

When acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 856, 857, 858, 867, 868, 869, with relative weights from 0.7297 to 4.5487 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of T80.22XA?

Under the General Equivalence Mappings, acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter converts to ICD-9-CM 999.34 (ac inf fol trans,inf bld). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.