ICD-10-CM Code A41

Other sepsis

Version 2020 Non-Billable Code

Not Valid for Submission

A41 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of other sepsis. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

Short Description:Other sepsis
Long Description:Other sepsis

Consider the following ICD-10 codes with a higher level of specificity:

  • A41.0 - Sepsis due to Staphylococcus aureus
  • A41.01 - Sepsis due to Methicillin susceptible Staphylococcus aureus
  • A41.02 - Sepsis due to Methicillin resistant Staphylococcus aureus
  • A41.1 - Sepsis due to other specified staphylococcus
  • A41.2 - Sepsis due to unspecified staphylococcus
  • A41.3 - Sepsis due to Hemophilus influenzae
  • A41.4 - Sepsis due to anaerobes
  • A41.5 - Sepsis due to other Gram-negative organisms
  • A41.50 - Gram-negative sepsis, unspecified
  • A41.51 - Sepsis due to Escherichia coli [E. coli]
  • A41.52 - Sepsis due to Pseudomonas
  • A41.53 - Sepsis due to Serratia
  • A41.59 - Other Gram-negative sepsis
  • A41.8 - Other specified sepsis
  • A41.81 - Sepsis due to Enterococcus
  • A41.89 - Other specified sepsis
  • A41.9 - Sepsis, unspecified organism

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code A41:

Code First

Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • postprocedural sepsis T81.4
  • sepsis during labor O75.3
  • sepsis following abortion, ectopic or molar pregnancy O03 O07 O08.0
  • sepsis following immunization T88.0
  • sepsis following infusion, transfusion or therapeutic injection T80.2

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • bacteremia NOS R78.81
  • neonatal P36
  • puerperal sepsis O85
  • streptococcal sepsis A40

Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • sepsis due to in actinomycotic A42.7
  • sepsis due to in anthrax A22.7
  • sepsis due to in candidal B37.7
  • sepsis due to in Erysipelothrix A26.7
  • sepsis due to in extraintestinal yersiniosis A28.2
  • sepsis due to in gonococcal A54.86
  • sepsis due to in herpesviral B00.7
  • sepsis due to in listerial A32.7
  • sepsis due to in melioidosis A24.1
  • sepsis due to in meningococcal A39.2 A39.4
  • sepsis due to in plague A20.7
  • sepsis due to in tularemia A21.7
  • toxic shock syndrome A48.3

Clinical Information

  • NEONATAL SEPSIS-. blood infection that occurs in an infant younger than 90 days old. early onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. late onset occurs after 1 week and before 3 months of age.
  • PREGNANCY COMPLICATIONS INFECTIOUS-. the co occurrence of pregnancy and an infection. the infection may precede or follow fertilization.
  • PUERPERAL INFECTION-. an infection occurring in puerperium the period of 6 8 weeks after giving birth.
  • SYSTEMIC INFLAMMATORY RESPONSE SYNDROME-. a systemic inflammatory response to a variety of clinical insults characterized by two or more of the following conditions: 1 fever >38 degrees c or hypothermia <36 degrees c; 2 tachycardia >90 beat/minute; 3 tachypnea >24 breaths/minute; 4 leukocytosis >12000 cells/cubic mm or 10% immature forms. while usually related to infection sirs can also be associated with noninfectious insults such as trauma; burns; or pancreatitis. if infection is involved a patient with sirs is said to have sepsis.
  • SEPSIS-. systemic inflammatory response syndrome with a proven or suspected infectious etiology. when sepsis is associated with organ dysfunction distant from the site of infection it is called severe sepsis. when sepsis is accompanied by hypotension despite adequate fluid infusion it is called septic shock.
  • BURKHOLDERIA INFECTIONS-. infections with bacteria of the genus burkholderia.
  • LEMIERRE SYNDROME-. a superinfection of the damaged oropharyngeal mucosa by fusobacterium necrophorum leading to the secondary septic thrombophlebitis of the internal jugular vein.
  • SEPSIS ASSOCIATED ENCEPHALOPATHY-. acute neurological dysfunction during severe sepsis in the absence of direct brain infection characterized by systemic inflammation and blood brain barrier perturbation.

Code Classification

  • Certain infectious and parasitic diseases (A00–B99)
    • Other bacterial diseases (A30-A49)
      • Other sepsis (A41)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Sepsis is a serious illness. It happens when your body has an overwhelming immune response to a bacterial infection. The chemicals released into the blood to fight the infection trigger widespread inflammation. This leads to blood clots and leaky blood vessels. They cause poor blood flow, which deprives your body's organs of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, blood pressure drops and the heart weakens, leading to septic shock.

Anyone can get sepsis, but the risk is higher in

  • People with weakened immune systems
  • Infants and children
  • Adults 65 and older
  • People with chronic illnesses, such as diabetes, AIDS, cancer, and kidney or liver disease
  • People suffering from a severe burn or physical trauma

Common symptoms of sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation. Doctors diagnose sepsis using a blood test to see if the number of white blood cells is abnormal. They also do lab tests that check for signs of infection.

People with sepsis are usually treated in hospital intensive care units. Doctors try to treat the infection, sustain the vital organs, and prevent a drop in blood pressure. Many patients receive oxygen and intravenous (IV) fluids. Other types of treatment, such as respirators or kidney dialysis, may be necessary. Sometimes, surgery is needed to clear up an infection.

NIH: National Institute of General Medical Sciences

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