2027 ICD-10-CM Diagnosis Code T50.995SAdverse effect of other drugs, medicaments and biological substances, sequela

ICD-10-CM Codes›S00–T88›T36-T50›T50

ICD-10-CM T50.995S
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T50.995S is a billable ICD-10-CM diagnosis code for adverse effect of other drugs, medicaments and biological substances, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.

Code Identity

ICD-10-CM Code
T50.995S
Billable Status
Yes — Valid for Submission
Code Describes
Adverse effect of other drugs, medicaments and biological substances, sequela
Short Description
Adverse effect of drug/meds/biol subst, sequela
Parent Code
Adverse effect of other drugs, medicaments and biological substances

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT50Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances
This CodeT50.995SAdverse effect of other drugs, medicaments and biological substances, sequela

Present on Admission (POA)Billing

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acitretin adverse reaction
  • Adverse cutaneous reaction to herbal medicine
  • Adverse cutaneous reaction to homeopathic medicine
  • Adverse reaction caused by bisphosphonate
  • Adverse reaction caused by canagliflozin
  • Adverse reaction caused by dapagliflozin
  • Adverse reaction caused by empagliflozin
  • Adverse reaction caused by ertugliflozin
  • Adverse reaction to allergenic extract
  • Adverse reaction to aluminum and/or aluminum compound
  • Adverse reaction to bile acid and/or bile acid derivative
  • Adverse reaction to bone resorption inhibitor
  • Adverse reaction to calcium carbonate and/or etidronic acid
  • Adverse reaction to chenodeoxycholic acid and/or ursodeoxycholic acid
  • Adverse reaction to clodronic acid
  • Adverse reaction to drug primarily acting on nutrition
  • Adverse reaction to etidronic acid
  • Adverse reaction to fatty acid
  • Adverse reaction to Fuller's earth
  • Adverse reaction to glycol
  • Adverse reaction to hyaluronic acid
  • Adverse reaction to inorganic chemical
  • Adverse reaction to oil
  • Adverse reaction to pamidronic acid
  • Adverse reaction to parathyroid hormone and/or parathyroid hormone derivative
  • Adverse reaction to phosphodiesterase 5 inhibitor
  • Adverse reaction to substance with sodium glucose cotransporter subtype 2 inhibitor mechanism of action
  • Aldehyde dehydrogenase inhibitor adverse reaction
  • Anionic surfactant adverse reaction
  • Antidotes for pesticides adverse reaction
  • Bone pain caused by granulocyte colony stimulating factor
  • Bufexamac adverse reaction
  • Calcitonin adverse reaction
  • Calcium polystyrene sulfonate adverse reaction
  • Calcium regulating agent adverse reaction
  • Calcium regulating hormone adverse reaction
  • Carbomer-940 adverse reaction
  • Cation exchange resin adverse reaction
  • Cellulose-derived viscosity modifier adverse reaction
  • Chorea caused by dopamine receptor antagonist
  • Citrate adverse reaction
  • Colchicum alkaloid adverse reaction
  • Collagen adverse reaction
  • Colony stimulating factors adverse reaction
  • Dimethyl-ether propane adverse reaction
  • Drug reaction with eosinophilia and systemic symptoms
  • Drug reaction with eosinophilia and systemic symptoms caused by strontium ranelate
  • Drug-induced dystonia
  • Drug-induced uveitis
  • Dystonia caused by dopamine receptor antagonist
  • Ear wax removal preparation adverse reaction
  • Electrolyte anion adverse reaction
  • Enbucrilate adverse reaction
  • Ergoline drug adverse reaction
  • Etretinate adverse reaction
  • Filgrastim adverse reaction
  • Fixed oil adverse reaction
  • Fluoride adverse reaction
  • Gold nephropathy
  • Hemostatic adverse reaction
  • Herbal medicine adverse reaction
  • Homeopathic medicine adverse reaction
  • Immunostimulant adverse reaction
  • Inositol adverse reaction
  • Ion exchange resin adverse reaction
  • Isotretinoin adverse reaction
  • Lenograstim adverse reaction
  • Methyl methacrylate embolism
  • Molgramostim adverse reaction
  • Nicotine adverse reaction
  • Non-ionic surfactant adverse reaction
  • Oral leukoplakia caused by sanguinarine
  • Osteonecrosis of jaw
  • Osteonecrosis of jaw caused by bisphosphonate
  • Osteonecrosis of jaw caused by drug
  • Pamidronic acid-induced uveitis
  • Parkinsonism caused by dopamine depleting agent
  • Parkinsonism caused by dopamine receptor antagonist
  • Parkinsonism caused by drug
  • p-di-Isobutylphenoxypolyethoxyethanol adverse reaction
  • Phosphodiesterase inhibitor adverse reaction
  • Radiopharmaceutical adverse reaction
  • Retinoid adverse reaction
  • Retinopathy caused by canthaxanthin
  • Salmon calcitonin adverse reaction
  • Sodium fluoride adverse reaction
  • Surgical tissue adhesive adverse reaction
  • Terpenes adverse reaction
  • Toxic chorea
  • Toxic dystonia
  • Urinary disorder monitoring status
  • Urinary drug side effect
  • Ursodeoxycholic acid adverse reaction
  • Viscosity modifier adverse reaction
  • Xanthine oxidase inhibitor adverse reaction

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T50.995S: its own notes plus those printed at T50, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Code First

The underlying condition named in the note is sequenced before this code.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T50 Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances applies to 342 codes
  • The appropriate 7th character is to be added to each code from category T50
  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela this code

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T50.995S, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming T50.995S: they are not reported together with it, unless the two conditions are unrelated.

  • T38 Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified
    parathyroid hormones and derivatives (T50.9-) names T50.9-, which includes this code

Use Additional Code 1

These codes say to use an additional code from the note, and T50.995S is one of the codes named.

  • G61.1 Serum neuropathy
    code for adverse effect, if applicable, to identify serum (T50.-) names T50.-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ075
Poisoning/toxic effect/adverse effects/underdosing, sequela
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
Acetohydroxamic acidT50.991T50.992T50.993T50.994T50.995T50.996
AcitretinT50.991T50.992T50.993T50.994T50.995T50.996
Ammonium::chlorideT50.991T50.992T50.993T50.994T50.995T50.996
ArginineT50.991T50.992T50.993T50.994T50.995T50.996
Arginine::glutamateT50.991T50.992T50.993T50.994T50.995T50.996
Baking sodaT50.991T50.992T50.993T50.994T50.995T50.996
BergaptenT50.991T50.992T50.993T50.994T50.995T50.996
BHAT50.991T50.992T50.993T50.994T50.995T50.996
Borate (s)::bufferT50.991T50.992T50.993T50.994T50.995T50.996
Bromophenol blue reagentT50.991T50.992T50.993T50.994T50.995T50.996
Butylated hydroxy-anisoleT50.991T50.992T50.993T50.994T50.995T50.996
CalcitoninT50.991T50.992T50.993T50.994T50.995T50.996
Calcium::chlorideT50.991T50.992T50.993T50.994T50.995T50.996
Calcium::chloride::anhydrousT50.991T50.992T50.993T50.994T50.995T50.996
Calculus-dissolving drugT50.991T50.992T50.993T50.994T50.995T50.996
CanthaxanthinT50.991T50.992T50.993T50.994T50.995T50.996
CetomacrogolT50.991T50.992T50.993T50.994T50.995T50.996
ChlorophyllT50.991T50.992T50.993T50.994T50.995T50.996
Choline::chlorideT50.991T50.992T50.993T50.994T50.995T50.996
Choline::dihydrogen citrateT50.991T50.992T50.993T50.994T50.995T50.996
CianidanolT50.991T50.992T50.993T50.994T50.995T50.996
Clodronic acidT50.991T50.992T50.993T50.994T50.995T50.996
Cochineal::medicinal productsT50.991T50.992T50.993T50.994T50.995T50.996
Coenzyme AT50.991T50.992T50.993T50.994T50.995T50.996
Cogalactoiso-meraseT50.991T50.992T50.993T50.994T50.995T50.996
CollagenT50.991T50.992T50.993T50.994T50.995T50.996
Colorant [See Also: Dye]T50.991T50.992T50.993T50.994T50.995T50.996
CyclamateT50.991T50.992T50.993T50.994T50.995T50.996
Deanol (aceglumate)T50.991T50.992T50.993T50.994T50.995T50.996
Drug NEC::specified NECT50.991T50.992T50.993T50.994T50.995T50.996
ElcatoninT50.991T50.992T50.993T50.994T50.995T50.996
EpomediolT50.991T50.992T50.993T50.994T50.995T50.996
EtidronateT50.991T50.992T50.993T50.994T50.995T50.996
Etidronic acid (disodium salt)T50.991T50.992T50.993T50.994T50.995T50.996
EtretinateT50.991T50.992T50.993T50.994T50.995T50.996
Fat suspension, intravenousT50.991T50.992T50.993T50.994T50.995T50.996
Fluoride (nonmedicinal) (pesticide) (sodium) NEC::medicinal NECT50.991T50.992T50.993T50.994T50.995T50.996
Gallium citrateT50.991T50.992T50.993T50.994T50.995T50.996
GelsemineT50.991T50.992T50.993T50.994T50.995T50.996
Gluconic acidT50.991T50.992T50.993T50.994T50.995T50.996
GlycerophosphateT50.991T50.992T50.993T50.994T50.995T50.996
Guaiac reagentT50.991T50.992T50.993T50.994T50.995T50.996
Hormone::parathyroid (derivatives)T50.991T50.992T50.993T50.994T50.995T50.996
InositolT50.991T50.992T50.993T50.994T50.995T50.996
Intravenous::amino acidsT50.991T50.992T50.993T50.994T50.995T50.996
Intravenous::fat suspensionT50.991T50.992T50.993T50.994T50.995T50.996
Iodine (antiseptic, external) (tincture) NEC::125 [See Also: Radiation sickness, and exposure to radioactive isotopes]::therapeuticT50.991T50.992T50.993T50.994T50.995T50.996
IsotretinoinT50.991T50.992T50.993T50.994T50.995T50.996
LevocarnitineT50.991T50.992T50.993T50.994T50.995T50.996
LevoglutamideT50.991T50.992T50.993T50.994T50.995T50.996
MacrogolT50.991T50.992T50.993T50.994T50.995T50.996
Manganese (dioxide) (salts)::medicinalT50.991T50.992T50.993T50.994T50.995T50.996
MethionineT50.991T50.992T50.993T50.994T50.995T50.996
MethoxsalenT50.991T50.992T50.993T50.994T50.995T50.996
5-Methoxypsoralen (5-MOP)T50.991T50.992T50.993T50.994T50.995T50.996
8-Methoxypsoralen (8-MOP)T50.991T50.992T50.993T50.994T50.995T50.996
Methylethyl celluloseT50.991T50.992T50.993T50.994T50.995T50.996
MonooctanoinT50.991T50.992T50.993T50.994T50.995T50.996
OctanoinT50.991T50.992T50.993T50.994T50.995T50.996
OrazamideT50.991T50.992T50.993T50.994T50.995T50.996
Ornithine aspartateT50.991T50.992T50.993T50.994T50.995T50.996
Oxalic acid::ammonium saltT50.991T50.992T50.993T50.994T50.995T50.996
Palm kernel oilT50.991T50.992T50.993T50.994T50.995T50.996
ParathormoneT50.991T50.992T50.993T50.994T50.995T50.996
Parathyroid extractT50.991T50.992T50.993T50.994T50.995T50.996
Phenaphthazine reagentT50.991T50.992T50.993T50.994T50.995T50.996
Potassium (salts) NEC::citrateT50.991T50.992T50.993T50.994T50.995T50.996
Protein hydrolysateT50.991T50.992T50.993T50.994T50.995T50.996
Psoralens (medicinal)T50.991T50.992T50.993T50.994T50.995T50.996
SerotoninT50.991T50.992T50.993T50.994T50.995T50.996
SilibininT50.991T50.992T50.993T50.994T50.995T50.996
SilymarinT50.991T50.992T50.993T50.994T50.995T50.996
Sodium::citrateT50.991T50.992T50.993T50.994T50.995T50.996
Sodium::iodideT50.991T50.992T50.993T50.994T50.995T50.996
Sodium::magnesium citrateT50.991T50.992T50.993T50.994T50.995T50.996
Sodium::propyl hydroxybenzoateT50.991T50.992T50.993T50.994T50.995T50.996
Teriparatide (acetate)T50.991T50.992T50.993T50.994T50.995T50.996
ThioctamideT50.991T50.992T50.993T50.994T50.995T50.996
Thioctic acidT50.991T50.992T50.993T50.994T50.995T50.996
TidiacicT50.991T50.992T50.993T50.994T50.995T50.996
TioproninT50.991T50.992T50.993T50.994T50.995T50.996
TragacanthT50.991T50.992T50.993T50.994T50.995T50.996
Ursodeoxycholic acidT50.991T50.992T50.993T50.994T50.995T50.996
UrsodiolT50.991T50.992T50.993T50.994T50.995T50.996
Vienna::red::pharmaceutical dyeT50.991T50.992T50.993T50.994T50.995T50.996

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T50.995S to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
909.5 Lte efct advrs efct drug
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E947.8 Adv eff medicinal NEC
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T50.995SOverview

Is T50.995S a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of other drugs, medicaments and biological substances, sequela on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character S in T50.995S mean?

The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of other drugs, medicaments and biological substances itself has resolved, not the original event.

What MS-DRG does T50.995S group to?

When adverse effect of other drugs, medicaments and biological substances, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 923, 922, with relative weights from 0.9980 to 1.6248 depending on complications. Higher weights mean higher Medicare reimbursement.

Is T50.995S exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of other drugs, medicaments and biological substances, sequela on inpatient claims. The code appears in the Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50) range of the CMS exempt list.

Can T50.995S be reported with a code from O29.3?

Not as a rule. The Excludes1 note at block T36-T50, which applies to T50.995S, lists "toxic reaction to local anesthesia in pregnancy (O29.3-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).