2026 ICD-10-CM Diagnosis Code T50.4X5SAdverse effect of drugs affecting uric acid metabolism, sequela
T50.4X5S is a billable ICD-10-CM diagnosis code for adverse effect of drugs affecting uric acid metabolism, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T50.4X5S.
Present on Admission (POA)Billing
T50.4X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired pancytopenia
- Allopurinol adverse reaction
- Allopurinol hypersensitivity syndrome
- Colchicine adverse reaction
- Colchicum alkaloid adverse reaction
- Drug reaction with eosinophilia and systemic symptoms
- Gout drug side effect
- Gout monitoring status
- Pancytopenia caused by colchicine
- Probenecid adverse reaction
- Repeat prescription drug side effect
- Repeat prescription monitoring status
- Sulfinpyrazone adverse reaction
- Uricosuric agent adverse reaction
- Xanthine oxidase inhibitor adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Allopurinol
a xanthine oxidase inhibitor that decreases uric acid production. it also acts as an antimetabolite on some simpler organisms.Benzbromarone
uricosuric that acts by increasing uric acid clearance. it is used in the treatment of gout.Colchicine
a major alkaloid from colchicum autumnale l. and found also in other colchicum species. its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial mediterranean fever (periodic disease).Probenecid
the prototypical uricosuric agent. it inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.Sulfinpyrazone
a uricosuric drug that is used to reduce the serum urate levels in gout therapy. it lacks anti-inflammatory, analgesic, and diuretic properties.Urate Oxidase
an enzyme that catalyzes the conversion of urate and unidentified products. it is a copper protein. the initial products decompose to form allantoin. ec 1.7.3.3.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T50.4X5S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T50.4X5SOverview
Is T50.4X5S (Adverse effect of drugs affecting uric acid metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of drugs affecting uric acid metabolism, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T50.4X5S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of drugs affecting uric acid metabolism itself has resolved, not the original event.
What MS-DRG does T50.4X5S group to?
On inpatient claims, adverse effect of drugs affecting uric acid metabolism, sequela maps to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T50.4X5S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of drugs affecting uric acid metabolism, sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T50.4X5S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of drugs affecting uric acid metabolism, sequela on inpatient claims.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
