2026 ICD-10-CM Diagnosis Code T48.6X5SAdverse effect of antiasthmatics, sequela
T48.6X5S is a billable ICD-10-CM diagnosis code for adverse effect of antiasthmatics, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T48.6X5S.
Present on Admission (POA)Billing
T48.6X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to antiasthmatic
- Adverse reaction to cromolyn
- Adverse reaction to mast cell stabilizer
- Adverse reaction to purine derivative diuretic
- Adverse reaction to theobromine
- Adverse reaction to xanthine and/or xanthine derivative
- Aminophylline adverse reaction
- Bambuterol adverse reaction
- Bronchodilator preparations adverse reaction
- Choline theophyllinate adverse reaction
- Fenoterol adverse reaction
- Flunisolide adverse reaction
- Inhaled isoprenaline adverse reaction
- Ipratropium adverse reaction
- Isoetharine hydrochloride adverse reaction
- Isoprenaline adverse reaction
- Nedocromil adverse reaction
- Oral isoprenaline adverse reaction
- Oxitropium adverse reaction
- Parenteral isoprenaline adverse reaction
- Phosphodiesterase inhibitor adverse reaction
- Pirbuterol adverse reaction
- Reproterol adverse reaction
- Rimiterol adverse reaction
- Salbutamol adverse reaction
- Salmeterol adverse reaction
- Selective beta-2 adrenoceptor stimulants adverse reaction
- Terbutaline adverse reaction
- Theophylline adverse reaction
- Tulobuterol adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (T48). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Albuterol
a short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat asthma. albuterol is prepared as a racemic mixture of r(-) and s(+) stereoisomers. the stereospecific preparation of r(-) isomer of albuterol is referred to as levalbuterol.Albuterol, Ipratropium Drug Combination
a combined pharmaceutical preparation of ipratropium bromide and albuterol sulfate that is used to treat the symptoms of asthma and chronic obstructive pulmonary disease.Aminophylline
a drug combination that contains theophylline and ethylenediamine. it is more soluble in water than theophylline but has similar pharmacologic actions. it's most common use is in bronchial asthma, but it has been investigated for several other applications.Choline
a basic constituent of lecithin that is found in many plants and animal organs. it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.Choline Deficiency
a condition produced by a deficiency of choline in animals. choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. combined deficiency of choline (included in the b vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (from saunders dictionary & encyclopedia of laboratory medicine and technology, 1984)Choline Dehydrogenase
an enzyme bound to the inner mitochondrial membrane that catalyzes the oxidation of choline to betaine.Choline Kinase
an enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of atp. ethanolamine and its methyl and ethyl derivatives can also act as acceptors. ec 2.7.1.32.Choline O-Acetyltransferase
an enzyme that catalyzes the formation of acetylcholine from acetyl-coa and choline. ec 2.3.1.6.Choline-Phosphate Cytidylyltransferase
an enzyme that catalyzes the transfer of cytidylate (cmp) to choline phosphate to form cdpcholine. it is the rate-limiting enzyme in the choline pathway for the biosynthesis of phosphatidylcholine. its activity is increased by glucocorticoids. ec 2.7.7.15.Cholinergic Agents
any drug used for its actions on cholinergic systems. included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. the term cholinergic agents is sometimes still used in the narrower sense of muscarinic agonists, although most modern texts discourage that usage.Cholinergic Agonists
drugs that bind to and activate cholinergic receptors.Cholinergic Antagonists
drugs that bind to but do not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.Cholinergic Fibers
nerve fibers liberating acetylcholine at the synapse after an impulse.Cholinergic Neurons
neurons whose primary neurotransmitter is acetylcholine.Cholinesterase Inhibitors
drugs that inhibit cholinesterases. the neurotransmitter acetylcholine is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. when cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.Cholinesterase Reactivators
drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. they are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.Cholinesterases
drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. they are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.Cytidine Diphosphate Choline
donor of choline in biosynthesis of choline-containing phosphoglycerides.Diacylglycerol Cholinephosphotransferase
an enzyme that catalyzes the synthesis of phosphatidylcholines from cdpcholine and 1,2-diacylglycerols. ec 2.7.8.2.Glycerylphosphorylcholine
a component of phosphatidylcholines or lecithins, in which the two hydroxy groups of glycerol are esterified with fatty acids. (from stedman, 26th ed)Leukemia Inhibitory Factor
an interleukin-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. leukemia inhibitory factor binds to and acts through the lif receptor.Muscarinic Agonists
drugs that bind to and activate muscarinic cholinergic receptors (receptors, muscarinic). muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the gi tract, urinary bladder and the eye. they may also be used to reduce heart rate.Muscarinic Antagonists
drugs that bind to but do not activate muscarinic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, gi system, and salivary glands, gi motility, urinary bladder tone, and the central nervous system.Neuroimmunomodulation
the biochemical and electrophysiological interactions between the nervous system and immune system.Nicotinic Agonists
drugs that bind to and activate nicotinic cholinergic receptors (receptors, nicotinic). nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.Non-Neuronal Cholinergic System
the system of acetylcholine-synthesizing enzymes, transporters, receptors and degrading enzymes that characterize non-neuronal cholinergic cells such as airway and skin epithelial cells.Phosphatidylcholines
derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety.Phosphorylcholine
calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.Receptors, Cholinergic
cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.Solute Carrier Family 44, Member 2 Protein
a mitochondrion and plasma membrane protein that enables choline transmembrane transporter activity.Clenbuterol
a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. it is used as a bronchodilator in asthma.Fenoterol
a synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.Hexoprenaline
stimulant of adrenergic beta 2 receptors. it is used as a bronchodilator, antiasthmatic agent, and tocolytic agent.Isoproterenol
isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. it is used mainly as bronchodilator and heart stimulant.Levalbuterol
the r-isomer of albuterol.Nedocromil
a pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils; neutrophils; macrophages; mast cells; monocytes; and platelets.Terbutaline
a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.Theophylline
a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. theophylline inhibits the 3',5'-cyclic nucleotide phosphodiesterase that degrades cyclic amp thus potentiates the actions of agents that act through adenylyl cyclases and cyclic amp.Tretoquinol
an adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T48.6X5S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T48.6X5SOverview
Is T48.6X5S (Adverse effect of antiasthmatics) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of antiasthmatics, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T48.6X5S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of antiasthmatics itself has resolved, not the original event.
What MS-DRG does T48.6X5S group to?
On inpatient claims, adverse effect of antiasthmatics, sequela maps to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T48.6X5S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of antiasthmatics, sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T48.6X5S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of antiasthmatics, sequela on inpatient claims.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
