2027 ICD-10-CM Diagnosis Code T39.8X4APoisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T39

ICD-10-CM T39.8X4A
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T39.8X4A is a billable ICD-10-CM diagnosis code for poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 917 through 918. Coders also document this condition as analgesic overuse headache. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under External cause codes: intent of injury, undetermined; External cause codes: poisoning by drug; and Poisoning by drugs, initial encounter.

Code Identity

ICD-10-CM Code
T39.8X4A
Billable Status
Yes — Valid for Submission
Code Describes
Poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter
Short Description
Poisoning by oth nonopio analges/antipyret, NEC, undet, init
Parent Code
Poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT39Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics
This CodeT39.8X4APoisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Analgesic overuse headache
  • Medication overuse headache

Coding GuidelinesGuidance

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (T39). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T39.8X4A: its own notes plus those printed at T39, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Code First

The underlying condition named in the note is sequenced before this code.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T39 Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics applies to 162 codes
  • The appropriate 7th character is to be added to each code from category T39
  • Ainitial encounter this code
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR EXT023
External cause codes: intent of injury, undetermined
Default principal diagnosis: inpatient No · outpatient No
CCSR EXT014
External cause codes: poisoning by drug
Default principal diagnosis: inpatient No · outpatient No
CCSR INJ022
Poisoning by drugs, initial encounter
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
AcetylphenylhydrazineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Analgesic::specified NECT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Antipyretic::specified NECT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
CarbipheneT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
ClonixinT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
CropropamideT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
CrotethamideT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
CryogenineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
CyclopyrabitalT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
DarvonT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
DiclonixineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
DoloxeneT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
EmorfazoneT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
EtomideT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
FloctafenineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
FluradolineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
GlafenineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Jamaica::dogwood (bark)T39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
KetorolacT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
LefetamineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
MeptazinolT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
MethopholineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
MetofolineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
NefopamT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
OxetoroneT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Pentosan polysulfate (sodium)T39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
PerisoxalT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
PhenazopyridineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
PhenicarbazideT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Phenyramidol, phenyramidonT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Piroxicam::beta-cyclodextrin complexT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Piscidia (bark) (erythrina)T39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
PyrabitalT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
PyridiumT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
Rimazolium metilsulfateT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
SumatriptanT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
TiaramideT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
TinoridineT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
VersidyneT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
ViminolT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6
ZactaneT39.8X1T39.8X2T39.8X3T39.8X4T39.8X5T39.8X6

Patient EducationClinical

Pain Relievers

Pain relievers are medicines that reduce or relieve headaches, sore muscles, arthritis, or other aches and pains. There are many different pain medicines, and each has advantages and risks. Some types of pain respond better to certain medicines than others. Each person may also have a slightly different response to a pain reliever.

The full article covers:

  • What are pain relievers?
  • What are the types of over-the-counter pain relievers?
  • What are prescription pain relievers?
  • What are some non-drug treatments for pain?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T39.8X4A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
965.7 Pois-no-narc analges NEC
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E980.0 Undeterm pois-analgesics
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T39.8X4AOverview

Is T39.8X4A a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character A in T39.8X4A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, such as an emergency visit or first evaluation.

What MS-DRG does T39.8X4A group to?

When poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 918, 917, with relative weights from 0.8716 to 1.5698 depending on complications. Higher weights mean higher Medicare reimbursement.

Can T39.8X4A be reported with a code from O29.3?

Not as a rule. The Excludes1 note at block T36-T50, which applies to T39.8X4A, lists "toxic reaction to local anesthesia in pregnancy (O29.3-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of T39.8X4A?

Under the General Equivalence Mappings, poisoning by other nonopioid analgesics and antipyretics, not elsewhere classified, undetermined, initial encounter converts to ICD-9-CM 965.7 (pois-no-narc analges NEC) and E980.0 (undeterm pois-analgesics). The mapping is approximate, so confirm the match fits the documentation.