2026 ICD-10-CM Diagnosis Code T39.315AAdverse effect of propionic acid derivatives, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T39

ICD-10-CM T39.315A
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

T39.315A is a billable ICD-10-CM diagnosis code for adverse effect of propionic acid derivatives, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as adverse reaction to ibuprofen. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code
T39.315A
Billable Status
Yes — Valid for Submission
Code Describes
Adverse effect of propionic acid derivatives, initial encounter
Short Description
Adverse effect of propionic acid derivatives, init encntr
Parent Code
T39.315
Adverse effect of propionic acid derivatives

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT39Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics
This CodeT39.315AAdverse effect of propionic acid derivatives, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T39.315A.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adverse reaction to ibuprofen
  • Adverse reaction to ketoprofen
  • Adverse reaction to naproxen
  • Fenoprofen adverse reaction
  • Flurbiprofen adverse reaction
  • Propionic acid derivative adverse reaction
  • Tiaprofenic acid adverse reaction

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (T39). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ028
Adverse effects of drugs and medicaments, initial encounter
Default principal diagnosis: inpatient No · outpatient Yes

Clinical InformationClinical

  • Fenoprofen

    a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.

  • Flurbiprofen

    an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. it has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase.

  • Ibuprofen

    a non-steroidal anti-inflammatory agent with analgesic, antipyretic, and anti-inflammatory properties

  • Ketoprofen

    an ibuprofen-type anti-inflammatory analgesic and antipyretic. it is used in the treatment of rheumatoid arthritis and osteoarthritis.

  • Carboxylesterase

    carboxylesterase is a serine-dependent esterase with wide substrate specificity. the enzyme is involved in the detoxification of xenobiotics and the activation of ester and of amide prodrugs.

  • Naproxen

    an anti-inflammatory agent with analgesic and antipyretic properties. both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

  • Oxaprozin

    an oxazole-propionic acid derivative, cyclooxygenase inhibitor, and non-steroidal anti-inflammatory drug that is used in the treatment of pain and inflammation associated with of osteoarthritis; rheumatoid arthritis; and arthritis, juvenile.

  • Suprofen

    an ibuprofen-type anti-inflammatory analgesic and antipyretic. it inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect		Under­dosing
CarprofenT39.311T39.312T39.313T39.314T39.315T39.316
EsflurbiprofenT39.311T39.312T39.313T39.314T39.315T39.316
FenoprofenT39.311T39.312T39.313T39.314T39.315T39.316
FlurbiprofenT39.311T39.312T39.313T39.314T39.315T39.316
IbufenacT39.311T39.312T39.313T39.314T39.315T39.316
IbuprofenT39.311T39.312T39.313T39.314T39.315T39.316
IbuproxamT39.311T39.312T39.313T39.314T39.315T39.316
KetoprofenT39.311T39.312T39.313T39.314T39.315T39.316
NaproxenT39.311T39.312T39.313T39.314T39.315T39.316
OxaprozinT39.311T39.312T39.313T39.314T39.315T39.316
SuprofenT39.311T39.312T39.313T39.314T39.315T39.316
Tiaprofenic acidT39.311T39.312T39.313T39.314T39.315T39.316

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T39.315A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
995.29 Adv eff med/biol NEC/NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E935.7 Adv eff non-narc analgsc
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About T39.315AOverview

Is T39.315A (Adverse effect of propionic acid derivatives) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of propionic acid derivatives, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What does the 7th character A in T39.315A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for adverse effect of propionic acid derivatives, such as an emergency visit or first evaluation.

What MS-DRG does T39.315A group to?

On inpatient claims, adverse effect of propionic acid derivatives, initial encounter maps to MS-DRG 917, 918, with relative weights from 0.8571 to 1.5684 depending on complications. Higher weights mean higher Medicare reimbursement.

Can T39.315A be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of propionic acid derivatives, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

What is the ICD-9 equivalent of T39.315A?

Under the General Equivalence Mappings, adverse effect of propionic acid derivatives, initial encounter converts to ICD-9-CM 995.29 (adv eff med/biol NEC/NOS) and E935.7 (adv eff non-narc analgsc). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.