2027 ICD-10-CM Diagnosis Code T39.315AAdverse effect of propionic acid derivatives, initial encounter

ICD-10-CM T39.315A

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T39.315A is a billable ICD-10-CM diagnosis code for adverse effect of propionic acid derivatives, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as adverse reaction to ibuprofen. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code

T39.315A

Billable Status

Yes — Valid for Submission

Code Describes

Adverse effect of propionic acid derivatives, initial encounter

Short Description

Adverse effect of propionic acid derivatives, init encntr

Parent Code

T39.315

Adverse effect of propionic acid derivatives

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes

SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

CategoryT39Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics

This CodeT39.315AAdverse effect of propionic acid derivatives, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T39.315A.

Unacceptable principal diagnosis

There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

Adverse reaction to ibuprofen
Adverse reaction to ketoprofen
Adverse reaction to naproxen
Fenoprofen adverse reaction
Flurbiprofen adverse reaction
Propionic acid derivative adverse reaction
Tiaprofenic acid adverse reaction

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (T39). Use the following options for the applicable episode of care:

A - initial encounter
D - subsequent encounter
S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T39.315A: its own notes plus those printed at T39, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.