2026 ICD-10-CM Diagnosis Code R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

ICD-10-CM Codes›R00–R99›R50-R69›R65

ICD-10-CM R65.10
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R65.10 is a billable ICD-10-CM diagnosis code for systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as non-infectious systemic inflammatory response syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other general signs and symptoms.

Code Identity

ICD-10-CM Code
R65.10
Billable Status
Yes — Valid for Submission
Code Describes
Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
Short Description
SIRS of non-infectious origin w/o acute organ dysfunction
Parent Code
R65.1
Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR50-R69General symptoms and signs
CategoryR65Symptoms and signs specifically associated with systemic inflammation and infection
This CodeR65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

Code EditsBilling

Medicare Code Editor checks that affect claim validity for R65.10.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Non-infectious systemic inflammatory response syndrome
  • Non-infectious systemic inflammatory response syndrome without acute organ failure
  • Systemic inflammatory response syndrome
  • Systemic inflammatory response syndrome without organ dysfunction

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Systemic inflammatory response syndrome (SIRS) NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Syndrome
      • systemic inflammatory response (SIRS), of non-infectious origin (without organ dysfunction)
    • System, systemic
      • inflammatory response syndrome (SIRS) of non-infectious origin (without organ dysfunction)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM016
Other general signs and symptoms
Default principal diagnosis: inpatient No · outpatient Yes

Clinical InformationClinical

  • Systemic Inflammatory Response Syndrome

    a systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees c or hypothermia <36 degrees c; (2) tachycardia >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) leukocytosis >12,000 cells/cubic mm or 10% immature forms. while usually related to infection, sirs can also be associated with noninfectious insults such as trauma; burns; or pancreatitis. if infection is involved, a patient with sirs is said to have sepsis.

Convert R65.10 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
995.93 SIRS-noninf w/o ac or ds
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R65.10Overview

Is R65.10 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can R65.10 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

What is the ICD-9 equivalent of R65.10?

Under the General Equivalence Mappings, systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction converts to ICD-9-CM 995.93 (SIRS-noninf w/o ac or ds). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.