2026 ICD-10-CM Diagnosis Code R65Symptoms and signs specifically associated with systemic inflammation and infection

ICD-10-CM Codes›R00–R99›R50-R69›R65

ICD-10-CM R65
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R65 is a non-billable ICD-10-CM category code for symptoms and signs specifically associated with systemic inflammation and infection, so it cannot be submitted on claims. Use a more specific code from this category instead, such as R65.10, R65.11, R65.20, and R65.21. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.

Code Identity

ICD-10-CM Code
R65
Billable Status
No — Non-Billable Category
Code Describes
Symptoms and signs specifically associated with systemic inflammation and infection
Chapter
R50-R69
General symptoms and signs

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR50-R69General symptoms and signs
CategoryR65Symptoms and signs specifically associated with systemic inflammation and infection
This CodeR65Symptoms and signs specifically associated with systemic inflammation and infection

Specific Coding for Symp and signs specifically assoc w sys inflam and infctOverview

Non-specific codes like R65 require more characters. Use one of these billable codes instead:

  • R65.1 for Systemic inflammatory response syndrome (SIRS) of non-infectious origin

  • Use R65.10 for Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

  • Use R65.11 for Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

  • R65.2 for Severe sepsis

  • Use R65.20 for Severe sepsis without septic shock

  • Use R65.21 for Severe sepsis with septic shock

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R65Overview

Is R65 a billable code?

No. This is a category header that groups the codes for symptoms and signs specifically associated with systemic inflammation and infection, and headers cannot be submitted on claims. Claims for symptoms and signs specifically associated with systemic inflammation and infection need a more specific code from this category, such as R65.10, R65.11, and R65.20.

Can R65 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the symptoms and signs specifically associated with systemic inflammation and infection is established, that condition takes the principal position instead.