Symptoms and signs specifically associated with systemic inflammation and infection (R65) ICD-10-CM
The R65 code range covers symptoms and signs specifically associated with systemic inflammation and infection with 7 ICD-10-CM diagnosis codes. 4 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the R65 Range 7 codes · 4 billable
- R65 Symptoms and signs specifically associated with systemic inflammation and infectionNon-billable
- R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious originNon-billable
- R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
- R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
- R65.2 Severe sepsisNon-billable
- R65.20 Severe sepsis without septic shock
- R65.21 Severe sepsis with septic shock
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the R65 range.
Severe Sepsis
Sepsis associated with organ dysfunction distant from the site of infection.
About the R65 Code Range
These signs and symptoms relate to body-wide inflammation and infection. The subdivisions separate an inflammatory response not caused by infection from severe sepsis.
R65.1 groups the noninfectious responses by whether acute organ dysfunction is absent (R65.10) or present (R65.11). R65.2 separates severe sepsis without septic shock (R65.20) from severe sepsis with septic shock (R65.21).
Questions About This Page
How many billable codes are in the R65 range?
Of the 7 codes in this range, 4 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the R65 range classify?
The range classifies symptoms and signs specifically associated with systemic inflammation and infection. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
