Malaise and fatigue (R53) ICD-10-CM
The R53 code range covers malaise and fatigue with 8 ICD-10-CM diagnosis codes. 6 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the R53 Range 8 codes · 6 billable
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the R53 range.
Asthenia
Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.
Fatigue
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Functional Quadriplegia
The inability to move due to disability or physical condition, not related to spinal or brain damage.
Lethargy
A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.
About the R53 Code Range
Malaise means feeling generally unwell, while fatigue means feeling tired. This category also includes weakness and functional quadriplegia.
The subdivisions separate fatigue related to cancer (R53.0), weakness (R53.1), and functional quadriplegia (R53.2) from other malaise and fatigue (R53.8). Within that last group, the codes distinguish other malaise (R53.81), unspecified chronic fatigue (R53.82), and other fatigue (R53.83).
Questions About This Page
How many billable codes are in the R53 range?
Of the 8 codes in this range, 6 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the R53 range classify?
The range classifies malaise and fatigue. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
